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The epidemiology and impact of pain in osteoarthritis.

Tuhina Neogi
- 01 Sep 2013 - 
- Vol. 21, Iss: 9, pp 1145-1153
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TLDR
More insights are needed into pain mechanisms in OA to enable rational mechanism-based management of pain and to contribute to a substantial socioeconomic burden.
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This article is published in Osteoarthritis and Cartilage.The article was published on 2013-09-01 and is currently open access. It has received 1096 citations till now. The article focuses on the topics: Chronic pain & Osteoarthritis.

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Osteoarthritis animal models for biomaterial-assisted osteochondral regeneration

TL;DR: In this article , the benefits and limitations of different animal models for osteochondral defects (OCD) regeneration are discussed and compared in the context of preclinical in-vivo studies of biomaterial-assisted osteoarthritic regeneration.
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Association of Osteoarthritis With Increased Risk of Parkinson's Disease: A Population‐Based, Longitudinal Follow‐Up Study

TL;DR: In this paper , a retrospective cohort study was conducted using Taiwan's Longitudinal Health Insurance Database 2005 to investigate whether patients with osteoarthritis (OA) are at a higher risk of developing Parkinson's disease.
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Bone Marrow Lesions and Magnetic Resonance Imaging–Detected Structural Abnormalities in Patients With Midfoot Pain and Osteoarthritis: A Cross‐Sectional Study

TL;DR: In people with persistent midfoot pain but no x-ray signs of OA, MRI findings suggested an under-recognised prevalence of Oa, particularly in the 2nd and 3rd cuneiform-metatarsal joints, where BML patterns were consistent with previously recognised sites of elevated mechanical loading.
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Test–Retest Reliability and Sensitivity to Change of Ultrasound‐Based Methods of Measuring Synovial Inflammation in Knee Osteoarthritis

TL;DR: In a clinical setting, US measures of inflammatory features of knee OA demonstrated substantial reliability and low-to-moderate sensitivity to change, whereas measures of structural OA features were less reliable.
References
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Journal Article

Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee.

TL;DR: WOMAC is a disease-specific purpose built high performance instrument for evaluative research in osteoarthritis clinical trials and fulfil conventional criteria for face, content and construct validity, reliability, responsiveness and relative efficiency.
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Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030.

TL;DR: These large projected increases in demand for total hip and knee arthroplasties provide a quantitative basis for future policy decisions related to the numbers of orthopaedic surgeons needed to perform these procedures and the deployment of appropriate resources to serve this need.
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Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010

Theo Vos, +363 more
- 15 Dec 2012 - 
TL;DR: Prevalence and severity of health loss were weakly correlated and age-specific prevalence of YLDs increased with age in all regions and has decreased slightly from 1990 to 2010, but population growth and ageing have increased YLD numbers and crude rates over the past two decades.
Journal Article

Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010 (vol 380, pg 2197, 2012)

TL;DR: In this article, a comprehensive update of disease burden worldwide incorporating a systematic reassessment of disease and injury-specific epidemiology has been done since the 1990 study, and the authors aimed to calculate disease burden globally and for 21 regions for 1990, 2005, and 2010 with methods to enable meaningful comparisons over time.
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Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010

Christopher J L Murray, +369 more
- 15 Dec 2012 - 
TL;DR: The results for 1990 and 2010 supersede all previously published Global Burden of Disease results and highlight the importance of understanding local burden of disease and setting goals and targets for the post-2015 agenda taking such patterns into account.
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