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Open AccessJournal ArticleDOI

The epidemiology and impact of pain in osteoarthritis.

Tuhina Neogi
- 01 Sep 2013 - 
- Vol. 21, Iss: 9, pp 1145-1153
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TLDR
More insights are needed into pain mechanisms in OA to enable rational mechanism-based management of pain and to contribute to a substantial socioeconomic burden.
About: 
This article is published in Osteoarthritis and Cartilage.The article was published on 2013-09-01 and is currently open access. It has received 1096 citations till now. The article focuses on the topics: Chronic pain & Osteoarthritis.

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Journal ArticleDOI

Kaempferol Alleviates the Interleukin-1β-Induced Inflammation in Rat Osteoarthritis Chondrocytes via Suppression of NF-κB.

Zhengling Zhuang, +2 more
- 14 Aug 2017 - 
TL;DR: Kaempferol, as a novel therapeutic active agent, may prevent, stop, or retard the progression of OA by inhibiting the NF-κB pathway.
Journal ArticleDOI

Is osteoarthritis one disease or a collection of many

Leticia A Deveza, +1 more
- 01 May 2018 - 
TL;DR: An updated summary of the most recent advances in the identification of meaningful OA phenotypes as well as limitations from previous approaches that can be addressed in future studies are provided.
Journal ArticleDOI

Association between lower limb osteoarthritis and incidence of depressive symptoms: data from the osteoarthritis initiative.

Nicola Veronese, +6 more
- 01 May 2017 - 
TL;DR: This is the first study of longitudinal data to demonstrate people with multi-site, hip or knee OA have a greater odds of developing depressive symptoms compared to people without OA, which suggests that OA may be associated with future mental health burden.
Journal ArticleDOI

Non-human primates as a model for aging

Ricki J. Colman
- 17 Jul 2017 - 
TL;DR: Limitations to the use of non-human primates in aging research exist but can be mitigated somewhat by the existence of available resources supported by the National Institutes of Health.
Journal ArticleDOI

Biomechanics, obesity, and osteoarthritis. The role of adipokines: When the levee breaks.

Vera Francisco, +10 more
- 28 Oct 2017 - 
TL;DR: The knowledge about the role of adipokines in cartilage and bone function is summarized, highlighting their contribution to the imbalance of joint homeostasis and, consequently, pathogenesis of osteoarthritis.
References
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Journal Article

Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee.

Nicholas Bellamy, +4 more
- 01 Dec 1988 - 
TL;DR: WOMAC is a disease-specific purpose built high performance instrument for evaluative research in osteoarthritis clinical trials and fulfil conventional criteria for face, content and construct validity, reliability, responsiveness and relative efficiency.
Journal ArticleDOI

Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030.

Steven M. Kurtz, +4 more
- 01 Apr 2007 - 
TL;DR: These large projected increases in demand for total hip and knee arthroplasties provide a quantitative basis for future policy decisions related to the numbers of orthopaedic surgeons needed to perform these procedures and the deployment of appropriate resources to serve this need.
Journal ArticleDOI

Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010

Theo Vos, +363 more
- 15 Dec 2012 - 
TL;DR: Prevalence and severity of health loss were weakly correlated and age-specific prevalence of YLDs increased with age in all regions and has decreased slightly from 1990 to 2010, but population growth and ageing have increased YLD numbers and crude rates over the past two decades.
Journal Article

Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010 (vol 380, pg 2197, 2012)

Christopher J L Murray, +4 more
- 01 Jan 2013 - 
TL;DR: In this article, a comprehensive update of disease burden worldwide incorporating a systematic reassessment of disease and injury-specific epidemiology has been done since the 1990 study, and the authors aimed to calculate disease burden globally and for 21 regions for 1990, 2005, and 2010 with methods to enable meaningful comparisons over time.
Journal ArticleDOI

Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010

Christopher J L Murray, +369 more
- 15 Dec 2012 - 
TL;DR: The results for 1990 and 2010 supersede all previously published Global Burden of Disease results and highlight the importance of understanding local burden of disease and setting goals and targets for the post-2015 agenda taking such patterns into account.
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