The inflammatory response in sepsis.
Markus Bosmann,Peter A. Ward +1 more
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TLDR
Recent insights into the signaling pathways in immune and phagocytic cells that underlie sepsis and SIRS are discussed and how these might be targeted for therapeutic interventions to reverse or attenuate pathways that lead to lethality during sepsi are considered.About:
This article is published in Trends in Immunology.The article was published on 2013-03-01 and is currently open access. It has received 382 citations till now. The article focuses on the topics: Systemic inflammatory response syndrome & Septic shock.read more
Citations
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Sepsis: a roadmap for future research
Jonathan Cohen,Jean Louis Vincent,Neill K. J. Adhikari,Flávia Ribeiro Machado,Derek C. Angus,Thierry Calandra,Katia Jaton,Stefano Giulieri,Julie Delaloye,Steven M. Opal,Kevin J. Tracey,Tom van der Poll,Eric Pelfrene +12 more
TL;DR: The understanding of the clinical epidemiology and management of sepsis is set out and how the present approaches might be challenged to develop a new roadmap for future research is asked.
Journal ArticleDOI
Sepsis: Current Dogma and New Perspectives
TL;DR: It is argued that it is time to delineate novel immunometabolic and neurophysiological mechanisms underlying the altered cellular bioenergetics and failure of epithelial and endothelial barriers that produce organ dysfunction and death.
Journal ArticleDOI
The immune system's role in sepsis progression, resolution, and long‐term outcome
Matthew J. Delano,Peter A. Ward +1 more
TL;DR: Efforts are focused on more clearly defining and effectively reversing the persistent immune cell dysfunction associated with long‐term sepsis mortality, which alters the innate and adaptive immune responses for sustained periods of time after clinical recovery.
Journal ArticleDOI
Sepsis-induced immune dysfunction: can immune therapies reduce mortality?
Matthew J. Delano,Peter A. Ward +1 more
TL;DR: These efforts are focused on defining and reversing the persistent immune cell dysfunction that is associated with mortality long after the acute events of sepsis have resolved.
Journal ArticleDOI
Complement in Immune and Inflammatory Disorders: Pathophysiological Mechanisms
Daniel Ricklin,John D. Lambris +1 more
TL;DR: This review provides an update about the functional and collaborative capabilities of complement, highlights major disease areas with known complement contribution, and indicates the potential for complement as a focal point in immunomodulatory strategies for treating inflammatory diseases.
References
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IL-15 Prevents Apoptosis, Reverses Innate and Adaptive Immune Dysfunction, and Improves Survival in Sepsis
Shigeaki Inoue,Jacqueline Unsinger,Christopher G. Davis,Jared T. Muenzer,Thomas A. Ferguson,Katherine Chang,Dale F. Osborne,Andrew T. Clark,Craig M. Coopersmith,Jonathan E. McDunn,Richard S. Hotchkiss +10 more
TL;DR: In conclusion, IL-15 prevents two immunopathologic hallmarks of sepsis, namely, apoptosis and immunosuppression, and improves survival in two different models ofsepsis.
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Evaluation of endotoxin models for the study of sepsis
Daniel G. Remick,Peter A. Ward +1 more
TL;DR: The cytokine response in focus of infection models, such as that induced by cecal ligation and puncture, was examined and found to be more similar to that observed in patients with sepsis than in endotoxin models.
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Antioxidant supplementation in sepsis and systemic inflammatory response syndrome.
Mette M. Berger,René Chioléro +1 more
TL;DR: Three antioxidant nutrients have demonstrated clinical benefits and reached level A evidence: a) selenium improves clinical outcome (infections, organ failure); b) glutamine reduces infectious complication in large-sized trials; and c) the association of eicosapentaenoic acid and micronutrients has significant anti-inflammatory effects.
Journal ArticleDOI
PPARγ and Oxidative Stress: Con(β) Catenating NRF2 and FOXO
TL;DR: The role of PPARγ in response to oxidative stress and its interaction with other signaling pathways implicated in this process are reviewed, an interaction that emerged as a potential new therapeutic target for several oxidative-related diseases.
Journal ArticleDOI
Enhancing Nrf2 Pathway by Disruption of Keap1 in Myeloid Leukocytes Protects against Sepsis
Xiaoni Kong,Rajesh K. Thimmulappa,Florin L. Craciun,Christopher Harvey,Anju Singh,Ponvijay Kombairaju,Sekhar P. Reddy,Daniel G. Remick,Shyam Biswal +8 more
TL;DR: This study shows that Nrf2 acts as a critical immunomodulator in leukocytes, controls host inflammatory response to bacterial infection, and protects against sepsis.
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The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
Mervyn Singer,Clifford S. Deutschman,Christopher W. Seymour,Manu Shankar-Hari,Djillali Annane,Michael Bauer,Rinaldo Bellomo,Gordon R. Bernard,Jean-Daniel Chiche,Craig M. Coopersmith,Richard S. Hotchkiss,Mitchell M. Levy,John C. Marshall,Greg S. Martin,Steven M. Opal,Gordon D. Rubenfeld,Gordon D. Rubenfeld,Tom van der Poll,Jean Louis Vincent,Derek C. Angus +19 more