The inflammatory response in sepsis.
Markus Bosmann,Peter A. Ward +1 more
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TLDR
Recent insights into the signaling pathways in immune and phagocytic cells that underlie sepsis and SIRS are discussed and how these might be targeted for therapeutic interventions to reverse or attenuate pathways that lead to lethality during sepsi are considered.About:
This article is published in Trends in Immunology.The article was published on 2013-03-01 and is currently open access. It has received 382 citations till now. The article focuses on the topics: Systemic inflammatory response syndrome & Septic shock.read more
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Platelet interactions with viruses and parasites.
Ana Lopez Alonso,Dermot Cox +1 more
TL;DR: A review of the known interactions between platelets and pathogens such as viruses, fungi and parasites indicates a similarity with bacteria-platelet interactions with receptors such as FcγRIIa and Toll-Like Receptors playing key roles with many pathogens.
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A bio-artificial renal epithelial cell system conveys survival advantage in a porcine model of septic shock.
Angela J. Westover,Deborah A. Buffington,Kimberly A. Johnston,Peter L. Smith,Christopher J. Pino,H. David Humes +5 more
TL;DR: The demonstration of conserved efficacy with BRECS therapy in a porcine SS model represents a crucial step toward returning renal cell therapy to the clinical setting, initially targeting ICU patients with acute kidney injury requiring continuous renal replacement therapy.
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Cyanidin ameliorates endotoxin-induced myocardial toxicity by modulating inflammation and oxidative stress through mitochondria and other factors
TL;DR: It is demonstrated that cyanidin as a constituent of the authors' food chain may be beneficial and has therapeutic potential in sepsis treatment or other myocardial oxidative and/or inflammation induced injuries.
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The characteristics and antioxidation of Oudemansiella radicata selenium polysaccharides on lipopolysaccharide-induced endo-toxemic mice.
Zheng Gao,Chen Zhang,Hui Liu,Yongfa Zhu,Zhenzhen Ren,Huijuan Jing,Shangshang Li,Jianjun Zhang,Xingtian Liu,Le Jia +9 more
TL;DR: The conclusions demonstrated that the polysaccharides by O. radicata might be suitable for functional foods and natural drugs in preventing the endo-toxemia and its complications, and providing references for exploitation and utilization of natural substances.
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microRNA‑15a‑5p participates in sepsis by regulating the inflammatory response of macrophages and targeting TNIP2
Yufeng Lou,Zhenrong Huang +1 more
TL;DR: Results demonstrated that miR-15a-5p inhibitor reduced the secretion of inflammatory cytokines and inhibited NF-κ pathway activation by targeting TNIP2, which may be associated with the progression of sepsis.
References
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TL;DR: Standardized procedures for inducing sepsis in mice and rats are defined by applying defined severity grades of sepsi through modulation of the position of cecal ligation.
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Immunosuppression in patients who die of sepsis and multiple organ failure.
Jonathan S. Boomer,Kathleen To,Kathy Chang,Osamu Takasu,Dale F. Osborne,Andrew H. Walton,Traci L. Bricker,Stephen D. Jarman,Daniel Kreisel,Alexander S. Krupnick,Anil Srivastava,Paul E. Swanson,Jonathan Green,Richard S. Hotchkiss +13 more
TL;DR: Patients who die in the ICU following sepsis compared with patients who die of nonsepsis etiologies have biochemical, flow cytometric, and immunohistochemical findings consistent with immunosuppression, and targeted immune-enhancing therapy may be a valid approach in selected patients with sepsi.
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Mervyn Singer,Clifford S. Deutschman,Christopher W. Seymour,Manu Shankar-Hari,Djillali Annane,Michael Bauer,Rinaldo Bellomo,Gordon R. Bernard,Jean-Daniel Chiche,Craig M. Coopersmith,Richard S. Hotchkiss,Mitchell M. Levy,John C. Marshall,Greg S. Martin,Steven M. Opal,Gordon D. Rubenfeld,Gordon D. Rubenfeld,Tom van der Poll,Jean Louis Vincent,Derek C. Angus +19 more