The inflammatory response in sepsis.
Markus Bosmann,Peter A. Ward +1 more
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TLDR
Recent insights into the signaling pathways in immune and phagocytic cells that underlie sepsis and SIRS are discussed and how these might be targeted for therapeutic interventions to reverse or attenuate pathways that lead to lethality during sepsi are considered.About:
This article is published in Trends in Immunology.The article was published on 2013-03-01 and is currently open access. It has received 382 citations till now. The article focuses on the topics: Systemic inflammatory response syndrome & Septic shock.read more
Citations
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Complement in disease: a defence system turning offensive
TL;DR: This Review summarizes the current view of the key activating, regulatory, and effector mechanisms of the complement system, highlighting important crosstalk connections, and discusses the involvement of complement in clinical conditions and promising therapeutic approaches.
Journal ArticleDOI
TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins
Víctor M. Meseguer,Yeranddy A. Alpizar,Enoch Luis,Sendoa Tajada,Bristol Denlinger,Otto Fajardo,Jan-Albert Manenschijn,Carlos Fernández-Peña,Arturo Talavera,Tatiana Kichko,Belén Navia,Alicia Sanchez,Rosa Señarís,Peter W. Reeh,M. T. Pérez-García,José R. López-López,Thomas Voets,Carlos Belmonte,Karel Talavera,Félix Viana +19 more
TL;DR: This work shows that LPS exerts fast, membrane delimited, excitatory actions via TRPA1, a transient receptor potential cation channel that is critical for transducing environmental irritant stimuli into nociceptor activity, and finds that pain and acute vascular reactions, including neurogenic inflammation (CGRP release) caused by LPS are primarily dependent onTRPA1 channel activation in nocICEptive sensory neurons, and develop independently of TLR4 activation.
Journal ArticleDOI
Endothelial barrier dysfunction in septic shock
Steven M. Opal,T. van der Poll +1 more
TL;DR: Recent advances in the understanding of the signalling events that regulate endothelial function and molecular events that induce endothelial dysfunction in sepsis are highlighted.
Journal ArticleDOI
Procalcitonin: a promising diagnostic marker for sepsis and antibiotic therapy
TL;DR: The present article summarizes the relevance of procalcitonin in the diagnosis of sepsis and how it can be useful in determining the therapeutic approaches.
Journal ArticleDOI
Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis
Georg F. Weber,Georg F. Weber,Benjamin G. Chousterman,Shun He,Ashley M. Fenn,Manfred Nairz,Atsushi Anzai,Thorsten Brenner,Florian Uhle,Yoshiko Iwamoto,Clinton S. Robbins,L Noiret,Sarah L. Maier,Tina Zönnchen,Nuh N. Rahbari,Sebastian Schölch,Anne Klotzsche-von Ameln,Triantafyllos Chavakis,Jürgen Weitz,Stefan Hofer,Markus A. Weigand,Matthias Nahrendorf,Ralph Weissleder,Filip K. Swirski +23 more
TL;DR: It is reported that the cytokine interleukin-3 (IL-3) potentiates inflammation in sepsis, and is identified as an orchestrator of emergency myelopoiesis of Ly-6Chigh monocytes and neutrophils and fuels a cytokine storm.
References
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Jonathan S. Boomer,Kathleen To,Kathy Chang,Osamu Takasu,Dale F. Osborne,Andrew H. Walton,Traci L. Bricker,Stephen D. Jarman,Daniel Kreisel,Alexander S. Krupnick,Anil Srivastava,Paul E. Swanson,Jonathan Green,Richard S. Hotchkiss +13 more
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Mervyn Singer,Clifford S. Deutschman,Christopher W. Seymour,Manu Shankar-Hari,Djillali Annane,Michael Bauer,Rinaldo Bellomo,Gordon R. Bernard,Jean-Daniel Chiche,Craig M. Coopersmith,Richard S. Hotchkiss,Mitchell M. Levy,John C. Marshall,Greg S. Martin,Steven M. Opal,Gordon D. Rubenfeld,Gordon D. Rubenfeld,Tom van der Poll,Jean Louis Vincent,Derek C. Angus +19 more