The inflammatory response in sepsis.
Markus Bosmann,Peter A. Ward +1 more
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TLDR
Recent insights into the signaling pathways in immune and phagocytic cells that underlie sepsis and SIRS are discussed and how these might be targeted for therapeutic interventions to reverse or attenuate pathways that lead to lethality during sepsi are considered.About:
This article is published in Trends in Immunology.The article was published on 2013-03-01 and is currently open access. It has received 382 citations till now. The article focuses on the topics: Systemic inflammatory response syndrome & Septic shock.read more
Citations
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Extracorporeal life support and systemic inflammation
Abdulrahman A. Al-Fares,Abdulrahman A. Al-Fares,Abdulrahman A. Al-Fares,Tommaso Pettenuzzo,Tommaso Pettenuzzo,Lorenzo Del Sorbo +5 more
TL;DR: Two different but complementary pathophysiological perspectives will be developed in this review: ECLs as the cause of inflammation and ECLS as the treatment of inflammation, which may be useful in guiding the development of novel therapeutic strategies to improve the outcome of critical illness.
Journal ArticleDOI
Omega-9 Oleic Acid, the Main Compound of Olive Oil, Mitigates Inflammation during Experimental Sepsis.
Isabel M. Medeiros-de-Moraes,Cassiano Felippe Gonçalves-de-Albuquerque,Cassiano Felippe Gonçalves-de-Albuquerque,Angela R.M. Kurz,Angela R.M. Kurz,Angela R.M. Kurz,Flora Magno de Jesus Oliveira,Victor Hugo Pereira de Abreu,Rafael Carvalho Torres,Vinicius F. Carvalho,Vanessa Estato,Patrícia T. Bozza,Markus Sperandio,Hugo C. Castro-Faria-Neto,Hugo C. Castro-Faria-Neto,Adriana R. Silva +15 more
TL;DR: A beneficial anti-inflammatory role of omega-9 in sepsis is suggested, mitigating leukocyte rolling and leukocytes influx, balancing cytokine production, and controlling bacterial growth possibly through a PPAR gamma expression-dependent mechanism.
Journal ArticleDOI
T cells and their immunometabolism: A novel way to understanding sepsis immunopathogenesis and future therapeutics.
TL;DR: The therapeutic targeting of T cell immunometabolism (both conventional T cells and Tregs) during sepsis as a future immunomodulatory approach for its management is described.
Journal ArticleDOI
Sepsis-Induced Acute Kidney Injury
TL;DR: The role of the innate immune response to sepsis and its downstream effects on kidney structure and function with special reference to the adaptive cellular response and glomerular hemodynamic changes is highlighted.
Journal ArticleDOI
Sepsis Induces Hematopoietic Stem Cell Exhaustion and Myelosuppression through Distinct Contributions of TRIF and MYD88
Huajia Zhang,Sonia Rodríguez,Lin Wang,Soujuan Wang,Henrique Serezani,Reuben Kapur,Angelo A. Cardoso,Nadia Carlesso +7 more
TL;DR: In this article, the authors demonstrate that both cell-autonomous and non-cell autonomous TLR4 activation are major causes of myelosuppression during sepsis, while having a modest impact on hematopoietic stem cell function.
References
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The Epidemiology of Sepsis in the United States from 1979 through 2000
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TL;DR: Standardized procedures for inducing sepsis in mice and rats are defined by applying defined severity grades of sepsi through modulation of the position of cecal ligation.
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Immunosuppression in patients who die of sepsis and multiple organ failure.
Jonathan S. Boomer,Kathleen To,Kathy Chang,Osamu Takasu,Dale F. Osborne,Andrew H. Walton,Traci L. Bricker,Stephen D. Jarman,Daniel Kreisel,Alexander S. Krupnick,Anil Srivastava,Paul E. Swanson,Jonathan Green,Richard S. Hotchkiss +13 more
TL;DR: Patients who die in the ICU following sepsis compared with patients who die of nonsepsis etiologies have biochemical, flow cytometric, and immunohistochemical findings consistent with immunosuppression, and targeted immune-enhancing therapy may be a valid approach in selected patients with sepsi.
Related Papers (5)
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
Mervyn Singer,Clifford S. Deutschman,Christopher W. Seymour,Manu Shankar-Hari,Djillali Annane,Michael Bauer,Rinaldo Bellomo,Gordon R. Bernard,Jean-Daniel Chiche,Craig M. Coopersmith,Richard S. Hotchkiss,Mitchell M. Levy,John C. Marshall,Greg S. Martin,Steven M. Opal,Gordon D. Rubenfeld,Gordon D. Rubenfeld,Tom van der Poll,Jean Louis Vincent,Derek C. Angus +19 more