The inflammatory response in sepsis.
Markus Bosmann,Peter A. Ward +1 more
Reads0
Chats0
TLDR
Recent insights into the signaling pathways in immune and phagocytic cells that underlie sepsis and SIRS are discussed and how these might be targeted for therapeutic interventions to reverse or attenuate pathways that lead to lethality during sepsi are considered.About:
This article is published in Trends in Immunology.The article was published on 2013-03-01 and is currently open access. It has received 382 citations till now. The article focuses on the topics: Systemic inflammatory response syndrome & Septic shock.read more
Citations
More filters
Journal ArticleDOI
Long Noncoding RNA: Regulatory Mechanisms and Therapeutic Potential in Sepsis.
TL;DR: In this paper, a review of the role of long noncoding RNAs (lncRNAs) in sepsis is presented, which sheds light on their use as potential biomarkers and treatment targets.
Journal ArticleDOI
Epinecidin-1 protects mice from LPS-induced endotoxemia and cecal ligation and puncture-induced polymicrobial sepsis
TL;DR: Protective effects of Epi are tested against polymicrobial sepsis-induced bactericidal infection, inflammation and lung injury that result from cecal ligation and puncture in mice and in vitro studies revealed that Epi suppressed LPS-induced inflammatory cytokine production.
Journal ArticleDOI
Potentiation of complement regulator factor H protects human endothelial cells from complement attack in aHUS sera.
Richard B. Pouw,Richard B. Pouw,Mieke C. Brouwer,Marlon de Gast,Anna E. van Beek,Anna E. van Beek,Lambertus P. van den Heuvel,Lambertus P. van den Heuvel,Christoph Q. Schmidt,Arie van der Ende,Pilar Sánchez-Corral,Taco W. Kuijpers,Taco W. Kuijpers,Diana Wouters +13 more
TL;DR: Antibody-mediated potentiation of FH may serve as a highly effective approach to inhibit unwanted complement activation on human cells in a wide range of hematological diseases while preserving the protective role of complement against pathogens.
Journal ArticleDOI
Differential Thermoregulatory and Inflammatory Patterns in the Circadian Response to LPS-Induced Septic Shock.
Malena Lis Mul Fedele,Ignacio Aiello,Carlos S. Caldart,Diego A. Golombek,Luciano Marpegan,Natalia Paladino +5 more
TL;DR: A circadian dependency of the central thermoregulatory and peripheral inflammatory response to septic-shock is suggested, with TNF-α playing a central role in this circadian response.
Journal ArticleDOI
TLR5 agonist entolimod reduces the adverse toxicity of TNF while preserving its antitumor effects.
Gary Haderski,Bojidar M. Kandar,Craig M. Brackett,Ilia M. Toshkov,Christopher Johnson,Geraldine M. Paszkiewicz,Venkatesh Natarajan,Anatoli S. Gleiberman,Andrei V. Gudkov,Lyudmila G. Burdelya +9 more
TL;DR: It is found that entolimod pretreatment effectively protects livers and lungs from LPS- and TNF-induced toxicity and prevents mortality caused by combining either of these agents with the sensitizer, D-galactosamine.
References
More filters
Journal ArticleDOI
Free radicals and antioxidants in normal physiological functions and human disease
TL;DR: Attention is focussed on the ROS/RNS-linked pathogenesis of cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases, rheumatoid arthritis, and ageing.
Journal ArticleDOI
The Epidemiology of Sepsis in the United States from 1979 through 2000
TL;DR: The rate of sepsis due to fungal organisms increased by 207 percent, with gram-positive bacteria becoming the predominant pathogens after 1987, and the total in-hospital mortality rate fell, yet the total number of deaths continued to increase.
Journal ArticleDOI
The acute respiratory distress syndrome.
TL;DR: Progress has been made in understanding the mechanisms responsible for the pathogenesis and the resolution of lung injury, including the contribution of environmental and genetic factors, and on developing novel therapeutics that can facilitate and enhance lung repair.
Journal ArticleDOI
Immunodesign of experimental sepsis by cecal ligation and puncture.
TL;DR: Standardized procedures for inducing sepsis in mice and rats are defined by applying defined severity grades of sepsi through modulation of the position of cecal ligation.
Journal ArticleDOI
Immunosuppression in patients who die of sepsis and multiple organ failure.
Jonathan S. Boomer,Kathleen To,Kathy Chang,Osamu Takasu,Dale F. Osborne,Andrew H. Walton,Traci L. Bricker,Stephen D. Jarman,Daniel Kreisel,Alexander S. Krupnick,Anil Srivastava,Paul E. Swanson,Jonathan Green,Richard S. Hotchkiss +13 more
TL;DR: Patients who die in the ICU following sepsis compared with patients who die of nonsepsis etiologies have biochemical, flow cytometric, and immunohistochemical findings consistent with immunosuppression, and targeted immune-enhancing therapy may be a valid approach in selected patients with sepsi.
Related Papers (5)
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
Mervyn Singer,Clifford S. Deutschman,Christopher W. Seymour,Manu Shankar-Hari,Djillali Annane,Michael Bauer,Rinaldo Bellomo,Gordon R. Bernard,Jean-Daniel Chiche,Craig M. Coopersmith,Richard S. Hotchkiss,Mitchell M. Levy,John C. Marshall,Greg S. Martin,Steven M. Opal,Gordon D. Rubenfeld,Gordon D. Rubenfeld,Tom van der Poll,Jean Louis Vincent,Derek C. Angus +19 more