The inflammatory response in sepsis.
Markus Bosmann,Peter A. Ward +1 more
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TLDR
Recent insights into the signaling pathways in immune and phagocytic cells that underlie sepsis and SIRS are discussed and how these might be targeted for therapeutic interventions to reverse or attenuate pathways that lead to lethality during sepsi are considered.About:
This article is published in Trends in Immunology.The article was published on 2013-03-01 and is currently open access. It has received 382 citations till now. The article focuses on the topics: Systemic inflammatory response syndrome & Septic shock.read more
Citations
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Journal ArticleDOI
Activation of Hepatic STAT3 Maintains Pulmonary Defense during Endotoxemia
Kristie L. Hilliard,Eri Allen,Katrina E. Traber,Y. Kim,Gregory A. Wasserman,Matthew R. Jones,Joseph P. Mizgerd,Lee J. Quinton +7 more
TL;DR: Induction of liver STAT3-dependent gene expression programs is essential to countering the deleterious consequences of sepsis on pneumonia susceptibility and suggest that hepatic STAT3 activation promotes both cellular and humoral lung defenses.
Journal ArticleDOI
Identification of key genes and pathways using bioinformatics analysis in septic shock children
Junting Yang,Zhang Shunwen,Zhang Shunwen,Jie Zhang,Dong Jiangtao,Jiangdong Wu,Le Zhang,Peng Guo,Suyu Tang,Zhao Zhengyong,Hongzhou Wang,Yanheng Zhao,Wanjiang Zhang,Fang Wu +13 more
TL;DR: It is hypothesized that the discovery from the available gene expression data of pediatric sepsis patients could know the process or improve the situation and support future studies on pediatric septic shock.
Journal ArticleDOI
Caspase-8 inhibition represses initial human monocyte activation in septic shock model
Maria Jose Oliva-Martin,Luis Ignacio Sánchez-Abarca,Johanna Rodhe,Alejandro Carrillo-Jimenez,P Vlachos,Antonio J. Herrera,Albert García-Quintanilla,Teresa Caballero-Velázquez,José Antonio Pérez-Simón,Bertrand Joseph,José L. Venero +10 more
TL;DR: It is proposed that the therapeutic use of caspase-8 inhibitors could represent a more selective alternative that blocks both phases of septic shock at the source and also reduces LPS-induced expression and release of IL-1β and IL-10.
Journal ArticleDOI
Type 2 diabetes mellitus and sepsis: state of the art, certainties and missing evidence
TL;DR: In this paper, the authors summarized the strengths and weaknesses of current knowledge on the interplay between diabetes and sepsis and concluded that chronic exposure to high glucose might enhance immune adaptation, leading to reduced mortality rate in septic diabetic patients.
Book ChapterDOI
Diseases of the Alimentary Tract
Samuel L. Jones,Gilles Fecteau,Pamela J. Hullinger,Danelle A. Bickett-Weddle,Guy St. Jean,Sylvain Nichols,N. James MacLachlan,Christie E. Mayo,Paul H. Walz,Sébastien Buczinski,Franklyn B. Garry,Craig S. McConnel,David Francoz,André Desrochers,Raymond W. Sweeney,Spring K. Halland,Robert Bascom Sager,Bradford Smith,Michelle H. Barton,Jack Easley,Anthony T. Blikslager,Gayle D. Hallowell,Liara M. Gonzalez,Kelsey A. Hart,Jennifer Davis,Nicola Pusterla,John F. Marshall,Tiffany L. Hall,Chris Sanchez,Robert J. Callan,Nimet Browne,Francisco A. Uzal +31 more
References
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Mervyn Singer,Clifford S. Deutschman,Christopher W. Seymour,Manu Shankar-Hari,Djillali Annane,Michael Bauer,Rinaldo Bellomo,Gordon R. Bernard,Jean-Daniel Chiche,Craig M. Coopersmith,Richard S. Hotchkiss,Mitchell M. Levy,John C. Marshall,Greg S. Martin,Steven M. Opal,Gordon D. Rubenfeld,Gordon D. Rubenfeld,Tom van der Poll,Jean Louis Vincent,Derek C. Angus +19 more