The inflammatory response in sepsis.
Markus Bosmann,Peter A. Ward +1 more
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TLDR
Recent insights into the signaling pathways in immune and phagocytic cells that underlie sepsis and SIRS are discussed and how these might be targeted for therapeutic interventions to reverse or attenuate pathways that lead to lethality during sepsi are considered.About:
This article is published in Trends in Immunology.The article was published on 2013-03-01 and is currently open access. It has received 382 citations till now. The article focuses on the topics: Systemic inflammatory response syndrome & Septic shock.read more
Citations
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Elevated carbon monoxide to carbon dioxide ratio in the exhaled breath of mice treated with a single dose of lipopolysaccharide.
Arash Ghalyanchi Langeroudi,Charlotte M. Hirsch,Azadeh Shojaee Estabragh,Simone Meinardi,Donald R. Blake,Alan G. Barbour +5 more
TL;DR: By gas chromatographic analysis, the ratio of carbon monoxide to carbon dioxide increased in exhaled breath of 2 mouse strains injected with different doses of Escherichia coli lipopolysaccharide and the ratios correlated with inflammation biomarkers and heme oxygenase-1 expression in blood.
Journal ArticleDOI
The MAVS Immune Recognition Pathway in Viral Infection and Sepsis.
TL;DR: The role of MAVS as a sensor for nonviral pathogens, host cell injury, and metabolic perturbations awaits better characterization in the future as discussed by the authors, and the ultimate goal is to manipulate MAVS activities in the form of immune-modulatory therapies to combat infections and sepsis.
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The protective role of human ghrelin in sepsis: Restoration of CD4 T cell proliferation.
Mian Zhou,Monowar Aziz,Manhendar Ochani,Weng Lang Yang,Weng Lang Yang,Archna Sharma,Ping Wang,Ping Wang +7 more
TL;DR: Human ghrelin plays an important role in reestablishing the proliferation of CD4 T cells and serves as a promising therapeutic agent in sepsis.
Journal ArticleDOI
Spinal Cord Injury Increases Pro-inflammatory Cytokine Expression in Kidney at Acute and Sub-chronic Stages.
Shangrila Parvin,Clintoria R. Williams,Clintoria R. Williams,Simone A. Jarrett,Sandra M. Garraway +4 more
TL;DR: In this article, the authors investigated the impact of high and low thoracic (T) SCI on C-fos, TNFα, interleukin (IL)-1β, and IL-6 expression in the kidney at acute and sub-chronic timepoints.
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Surgery for patients with Alpha 1 Antitrypsin Deficiency: A review
TL;DR: Although not currently recommended in AATD, LVRS may have a role in a minority of patients and the value of Alpha 1 Antitrypsin (AAT) augmentation therapy following lung transplantation requires further study.
References
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TL;DR: Standardized procedures for inducing sepsis in mice and rats are defined by applying defined severity grades of sepsi through modulation of the position of cecal ligation.
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Immunosuppression in patients who die of sepsis and multiple organ failure.
Jonathan S. Boomer,Kathleen To,Kathy Chang,Osamu Takasu,Dale F. Osborne,Andrew H. Walton,Traci L. Bricker,Stephen D. Jarman,Daniel Kreisel,Alexander S. Krupnick,Anil Srivastava,Paul E. Swanson,Jonathan Green,Richard S. Hotchkiss +13 more
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The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
Mervyn Singer,Clifford S. Deutschman,Christopher W. Seymour,Manu Shankar-Hari,Djillali Annane,Michael Bauer,Rinaldo Bellomo,Gordon R. Bernard,Jean-Daniel Chiche,Craig M. Coopersmith,Richard S. Hotchkiss,Mitchell M. Levy,John C. Marshall,Greg S. Martin,Steven M. Opal,Gordon D. Rubenfeld,Gordon D. Rubenfeld,Tom van der Poll,Jean Louis Vincent,Derek C. Angus +19 more