The inflammatory response in sepsis.
Markus Bosmann,Peter A. Ward +1 more
Reads0
Chats0
TLDR
Recent insights into the signaling pathways in immune and phagocytic cells that underlie sepsis and SIRS are discussed and how these might be targeted for therapeutic interventions to reverse or attenuate pathways that lead to lethality during sepsi are considered.About:
This article is published in Trends in Immunology.The article was published on 2013-03-01 and is currently open access. It has received 382 citations till now. The article focuses on the topics: Systemic inflammatory response syndrome & Septic shock.read more
Citations
More filters
Journal ArticleDOI
Sepsis: a roadmap for future research
Jonathan Cohen,Jean Louis Vincent,Neill K. J. Adhikari,Flávia Ribeiro Machado,Derek C. Angus,Thierry Calandra,Katia Jaton,Stefano Giulieri,Julie Delaloye,Steven M. Opal,Kevin J. Tracey,Tom van der Poll,Eric Pelfrene +12 more
TL;DR: The understanding of the clinical epidemiology and management of sepsis is set out and how the present approaches might be challenged to develop a new roadmap for future research is asked.
Journal ArticleDOI
Sepsis: Current Dogma and New Perspectives
TL;DR: It is argued that it is time to delineate novel immunometabolic and neurophysiological mechanisms underlying the altered cellular bioenergetics and failure of epithelial and endothelial barriers that produce organ dysfunction and death.
Journal ArticleDOI
The immune system's role in sepsis progression, resolution, and long‐term outcome
Matthew J. Delano,Peter A. Ward +1 more
TL;DR: Efforts are focused on more clearly defining and effectively reversing the persistent immune cell dysfunction associated with long‐term sepsis mortality, which alters the innate and adaptive immune responses for sustained periods of time after clinical recovery.
Journal ArticleDOI
Sepsis-induced immune dysfunction: can immune therapies reduce mortality?
Matthew J. Delano,Peter A. Ward +1 more
TL;DR: These efforts are focused on defining and reversing the persistent immune cell dysfunction that is associated with mortality long after the acute events of sepsis have resolved.
Journal ArticleDOI
Complement in Immune and Inflammatory Disorders: Pathophysiological Mechanisms
Daniel Ricklin,John D. Lambris +1 more
TL;DR: This review provides an update about the functional and collaborative capabilities of complement, highlights major disease areas with known complement contribution, and indicates the potential for complement as a focal point in immunomodulatory strategies for treating inflammatory diseases.
References
More filters
Journal ArticleDOI
Novel insights for systemic inflammation in sepsis and hemorrhage.
TL;DR: The inflammatory responses and the anti-inflammatory strategies in experimental models of sepsis and hemorrhage are reviewed, as they may have a consistent inflammatory pathway in spite of their different pathophysiological processes.
Journal ArticleDOI
In vivo profile of the human leukocyte microRNA response to endotoxemia.
TL;DR: It is found that the rapid transcriptional activation during acute inflammation of select genes, such as the gene encoding interleukin-1 receptor-associated kinase 2 (IRAK2) might be facilitated by decreased levels of LPS-responsive miRNAs.
Journal ArticleDOI
Cannabinoids: A New Group of Agonists of PPARs
Yan Sun,Andrew J. Bennett +1 more
TL;DR: An increasing number of therapeutic actions of cannabinoid are being reported that do not appear to be mediated by either CB1 or CB2, and recently nuclear receptor superfamily PPARs (peroxisome-proliferator-activated receptors) have been suggested as the target of certain cannabinoids.
Journal ArticleDOI
The post sepsis-induced expansion and enhanced function of regulatory T cells create an environment to potentiate tumor growth.
Karen A. Cavassani,William F. Carson,Ana Paula Moreira,Haitao Wen,Matthew Schaller,Makoto Ishii,Dennis M. Lindell,Yali Dou,Nicholas W. Lukacs,Venkateshwar G. Keshamouni,Cory M. Hogaboam,Steven L. Kunkel +11 more
TL;DR: The data show that the post septic immune system obstructs tumor immunosurveillance, in part, by augmented Treg expansion and function.
Journal ArticleDOI
CD11c+ dendritic cells are required for survival in murine polymicrobial sepsis
Philip O. Scumpia,Priscilla F. McAuliffe,Kerri A. O’Malley,Ricardo Ungaro,Takefumi Uchida,Tadashi Matsumoto,Daniel G. Remick,Michael J. Clare-Salzler,Lyle L. Moldawer,Philip A. Efron +9 more
TL;DR: It is confirmed that DCs are essential in the septic response and suggest that strategies to maintain DC numbers or function may improve outcome, including intravenous injection of 107 wild-type DCs.
Related Papers (5)
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
Mervyn Singer,Clifford S. Deutschman,Christopher W. Seymour,Manu Shankar-Hari,Djillali Annane,Michael Bauer,Rinaldo Bellomo,Gordon R. Bernard,Jean-Daniel Chiche,Craig M. Coopersmith,Richard S. Hotchkiss,Mitchell M. Levy,John C. Marshall,Greg S. Martin,Steven M. Opal,Gordon D. Rubenfeld,Gordon D. Rubenfeld,Tom van der Poll,Jean Louis Vincent,Derek C. Angus +19 more