The inflammatory response in sepsis.
Markus Bosmann,Peter A. Ward +1 more
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TLDR
Recent insights into the signaling pathways in immune and phagocytic cells that underlie sepsis and SIRS are discussed and how these might be targeted for therapeutic interventions to reverse or attenuate pathways that lead to lethality during sepsi are considered.About:
This article is published in Trends in Immunology.The article was published on 2013-03-01 and is currently open access. It has received 382 citations till now. The article focuses on the topics: Systemic inflammatory response syndrome & Septic shock.read more
Citations
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Book ChapterDOI
Zinc Signals in Inflammation
Sannette C. Hall,Daren L. Knoell +1 more
TL;DR: This chapter discusses zinc signals in inflammation with a focus on zinc dependent modulation of select signaling pathways and the effects on immune cell function in response to potentially damaging challenges.
Journal ArticleDOI
Protective Effect of Poria Cocos Polysaccharides on Fecal Peritonitis-Induced Sepsis in Mice Through Inhibition of Oxidative Stress, Inflammation, Apoptosis, and Reduction of Treg Cells
TL;DR: Interestingly, PCP pre-treatment reduced inflammatory cytokines and oxidative stress in plasma and spleen and improved the resistance to FIP, and its molecular mechanism is related to antioxidative, anti-inflammation,Anti-apoptosis, and the reduction of Treg activity in splenic cells.
Journal ArticleDOI
Amarogentin has protective effects against sepsis-induced brain injury via modulating the AMPK/SIRT1/NF-κB pathway
Bihui Song,Wen-Hui Zhou +1 more
TL;DR: Amarogentin (AMA) is a secoiridoid glycoside that is mainly derived from SwertiaandGentiana roots, and has been confirmed to exhibit antioxidative, tumor-suppressive and anti-diabetic properties as discussed by the authors .
Journal ArticleDOI
Cytokines as Potential Biomarkers for Differential Diagnosis of Sepsis and Other Non-Septic Disease Conditions
Augustina Frimpong,Ewurama D. A. Owusu,Jones A. Amponsah,Elizabeth Obeng-Aboagye,William van der Puije,A. Frempong,Kwadwo A. Kusi,Michael F. Ofori +7 more
TL;DR: The data suggests that sepsis is associated with a higher pro-inflammatory environment and levels of IL-1β, IL-12 and IL-17A had significantly higher levels compared to febrile controls but lower levels of MIP1-β/ CCL4, RANTES/CCL5 and IP10/CXCL10 when compared to children with malaria and febRIle controls.
Journal ArticleDOI
Urine Hydrogen Peroxide Levels and Their Relation to Outcome in Patients with Sepsis, Septic Shock, and Major Burn Injury
Miklos Lipcsey,Maria Bergquist,Rebecca Sirén,Anders Larsson,Fredrik Huss,Jay Pravda,Mia Furebring,Jan Sjölin,Helena Janols +8 more
TL;DR: In this paper , the authors measured H2O2 concentrations in the urine of 82 patients with severe infections, such as sepsis, septic shock, and infections not fulfilling SEPSIS-3 criteria, in patients with major burn injury with associated systemic inflammation, and healthy subjects.
References
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The Epidemiology of Sepsis in the United States from 1979 through 2000
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Immunosuppression in patients who die of sepsis and multiple organ failure.
Jonathan S. Boomer,Kathleen To,Kathy Chang,Osamu Takasu,Dale F. Osborne,Andrew H. Walton,Traci L. Bricker,Stephen D. Jarman,Daniel Kreisel,Alexander S. Krupnick,Anil Srivastava,Paul E. Swanson,Jonathan Green,Richard S. Hotchkiss +13 more
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The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
Mervyn Singer,Clifford S. Deutschman,Christopher W. Seymour,Manu Shankar-Hari,Djillali Annane,Michael Bauer,Rinaldo Bellomo,Gordon R. Bernard,Jean-Daniel Chiche,Craig M. Coopersmith,Richard S. Hotchkiss,Mitchell M. Levy,John C. Marshall,Greg S. Martin,Steven M. Opal,Gordon D. Rubenfeld,Gordon D. Rubenfeld,Tom van der Poll,Jean Louis Vincent,Derek C. Angus +19 more