The inflammatory response in sepsis.
Markus Bosmann,Peter A. Ward +1 more
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TLDR
Recent insights into the signaling pathways in immune and phagocytic cells that underlie sepsis and SIRS are discussed and how these might be targeted for therapeutic interventions to reverse or attenuate pathways that lead to lethality during sepsi are considered.About:
This article is published in Trends in Immunology.The article was published on 2013-03-01 and is currently open access. It has received 382 citations till now. The article focuses on the topics: Systemic inflammatory response syndrome & Septic shock.read more
Citations
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Book ChapterDOI
High Cut Off Hemodialysis
Clara Day,Paul Cockwell +1 more
TL;DR: The clinical rationale for HCO-HD is to improve patient outcomes by removing molecules that contribute to a high mortality risk in patients who require dialysis for distinct clinical indications.
Journal Article
Nex-Gen Biomarkers-A Genetic Model of Sepsis
Mumtaz Ahmad Ansari,Piyush Gupta +1 more
TL;DR: Recent developments in this relatively new model of sepsis are tried to understand and its potential to be an ideal biomarker for sepsi in the future is understood.
Journal ArticleDOI
Activation of CD4+ T Cell–Derived Cannabinoid Receptor 2 Signaling Exacerbates Sepsis via Inhibiting IL-10
Jincheng Chen,Fu-Sheng Wang,Su Zhang,Qiao Lin,Hui Xu,Tengfei Zhu,Ling-Li Peng,Fulan Cen,Fang Li,Zhaoqin Wang,Carl G. Feng,Zhinan Yin,Yingxia Liu,Guoliang Zhang +13 more
TL;DR: Results suggested that the activation of CD4+ T cell–derived CB2 increased susceptibility to sepsis through inhibiting IL-10 production, and in the clinical environment, septic patients expressed enhanced CB2 mRNA levels compared with healthy donors in PBMCs, and their CB2 expression was inversely correlated with IL- 10.
Posted ContentDOI
Macrophage-derived miR-21 drives overwhelming glycolytic and inflammatory response during sepsis via repression of the PGE2/IL-10 axis.
TL;DR: A heretofore unknown role of macrophage miR21 is shown in the orchestrating the balance between anti-inflammatory mediators and metabolic reprogramming that drives cytokine storm and tissue damage during sepsis.
Journal ArticleDOI
Dexpramipexole ameliorates cognitive deficits in sepsis-associated encephalopathy through suppressing mitochondria-mediated pyroptosis and apoptosis
TL;DR: In this article, the effects of dexpramipexole (DPX) on cognitive function in a mouse model of sepsis-associated encephalopathy (SAE) induced by peripheral administration of lipopolysaccharide (LPS) and examining the potential mechanisms were examined.
References
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TL;DR: Standardized procedures for inducing sepsis in mice and rats are defined by applying defined severity grades of sepsi through modulation of the position of cecal ligation.
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Immunosuppression in patients who die of sepsis and multiple organ failure.
Jonathan S. Boomer,Kathleen To,Kathy Chang,Osamu Takasu,Dale F. Osborne,Andrew H. Walton,Traci L. Bricker,Stephen D. Jarman,Daniel Kreisel,Alexander S. Krupnick,Anil Srivastava,Paul E. Swanson,Jonathan Green,Richard S. Hotchkiss +13 more
TL;DR: Patients who die in the ICU following sepsis compared with patients who die of nonsepsis etiologies have biochemical, flow cytometric, and immunohistochemical findings consistent with immunosuppression, and targeted immune-enhancing therapy may be a valid approach in selected patients with sepsi.
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