The inflammatory response in sepsis.
Markus Bosmann,Peter A. Ward +1 more
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TLDR
Recent insights into the signaling pathways in immune and phagocytic cells that underlie sepsis and SIRS are discussed and how these might be targeted for therapeutic interventions to reverse or attenuate pathways that lead to lethality during sepsi are considered.About:
This article is published in Trends in Immunology.The article was published on 2013-03-01 and is currently open access. It has received 382 citations till now. The article focuses on the topics: Systemic inflammatory response syndrome & Septic shock.read more
Citations
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Sepsis: a roadmap for future research
Jonathan Cohen,Jean Louis Vincent,Neill K. J. Adhikari,Flávia Ribeiro Machado,Derek C. Angus,Thierry Calandra,Katia Jaton,Stefano Giulieri,Julie Delaloye,Steven M. Opal,Kevin J. Tracey,Tom van der Poll,Eric Pelfrene +12 more
TL;DR: The understanding of the clinical epidemiology and management of sepsis is set out and how the present approaches might be challenged to develop a new roadmap for future research is asked.
Journal ArticleDOI
Sepsis: Current Dogma and New Perspectives
TL;DR: It is argued that it is time to delineate novel immunometabolic and neurophysiological mechanisms underlying the altered cellular bioenergetics and failure of epithelial and endothelial barriers that produce organ dysfunction and death.
Journal ArticleDOI
The immune system's role in sepsis progression, resolution, and long‐term outcome
Matthew J. Delano,Peter A. Ward +1 more
TL;DR: Efforts are focused on more clearly defining and effectively reversing the persistent immune cell dysfunction associated with long‐term sepsis mortality, which alters the innate and adaptive immune responses for sustained periods of time after clinical recovery.
Journal ArticleDOI
Sepsis-induced immune dysfunction: can immune therapies reduce mortality?
Matthew J. Delano,Peter A. Ward +1 more
TL;DR: These efforts are focused on defining and reversing the persistent immune cell dysfunction that is associated with mortality long after the acute events of sepsis have resolved.
Journal ArticleDOI
Complement in Immune and Inflammatory Disorders: Pathophysiological Mechanisms
Daniel Ricklin,John D. Lambris +1 more
TL;DR: This review provides an update about the functional and collaborative capabilities of complement, highlights major disease areas with known complement contribution, and indicates the potential for complement as a focal point in immunomodulatory strategies for treating inflammatory diseases.
References
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Neutrophil-derived ROS contribute to oxidative DNA damage induction by quartz particles.
Damien van Berlo,Anton Wessels,Agnes W. Boots,Verena Wilhelmi,Agnes M. Scherbart,Kirsten Gerloff,Frederik J. van Schooten,Catrin Albrecht,Roel P. F. Schins +8 more
TL;DR: It is demonstrated that neutrophil-derived ROS significantly contribute to pulmonary oxidative stress responses after acute quartz exposure, yet their role in the associated induction of oxidative DNA damage could be shown only in vitro.
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Animal models of sepsis and its complications
TL;DR: Experimental findings suggest that models of acute infection in mice with pre-existing renal dysfunction may be useful in the development pathway for new therapeutic agents for sepsis.
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Complement activation product C5a is a selective suppressor of TLR4-induced, but not TLR3-induced, production of IL-27(p28) from macrophages
Markus Bosmann,Mikel D. Haggadone,Mark R. Hemmila,Firas S. Zetoune,J. Vidya Sarma,Peter A. Ward +5 more
TL;DR: It is reported that C5a robustly suppressed IL-27(p28) gene expression and release in peritoneal macrophages and provides new evidence about how complement activation may selectively interfere with production of T cell regulatory cytokines by APCs in the varying contexts of either bacterial ( TLR4 pathway) or viral (TLR3 pathway) infection.
Journal ArticleDOI
Sepsis: from bench to bedside
Eliezer Silva,Rogério da Hora Passos,Maurício Beller Ferri,Luiz Francisco Poli de Figueiredo +3 more
TL;DR: The research efforts that have been targeting risk factor identification, including genetics, pathophysiological mechanisms and strategies to recognize and treat sepsis patients as early as possible are addressed.
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The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
Mervyn Singer,Clifford S. Deutschman,Christopher W. Seymour,Manu Shankar-Hari,Djillali Annane,Michael Bauer,Rinaldo Bellomo,Gordon R. Bernard,Jean-Daniel Chiche,Craig M. Coopersmith,Richard S. Hotchkiss,Mitchell M. Levy,John C. Marshall,Greg S. Martin,Steven M. Opal,Gordon D. Rubenfeld,Gordon D. Rubenfeld,Tom van der Poll,Jean Louis Vincent,Derek C. Angus +19 more