The inflammatory response in sepsis.
Markus Bosmann,Peter A. Ward +1 more
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TLDR
Recent insights into the signaling pathways in immune and phagocytic cells that underlie sepsis and SIRS are discussed and how these might be targeted for therapeutic interventions to reverse or attenuate pathways that lead to lethality during sepsi are considered.About:
This article is published in Trends in Immunology.The article was published on 2013-03-01 and is currently open access. It has received 382 citations till now. The article focuses on the topics: Systemic inflammatory response syndrome & Septic shock.read more
Citations
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A New Look at the Structures of Old Sepsis Actors by Exploratory Data Analysis Tools.
TL;DR: This work analyzed the ability of two different types of algorithms to provide information on the structures present in three data sets built using the experimental structures of allosteric proteins involved in sepsis, proving the effectiveness of random projection methods in structural bioinformatics.
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Plasma Metabolic Profiling of Pediatric Sepsis in a Chinese Cohort
TL;DR: This study performed comprehensive metabolomic profiling of plasma samples collected from pediatric sepsis patients to identify specific metabolic alterations associated with these patients as compared to healthy cohorts, revealing a panel of metabolites responsible for the discrimination between case and control subjects with a high predictive value of prognosis.
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Echinochrome pigment extracted from sea urchin suppress the bacterial activity, inflammation, nociception, and oxidative stress resulted in the inhibition of renal injury in septic rats.
TL;DR: In this paper, the authors evaluated the antibacterial, anti-inflammatory, analgesic, and renoprotective effects of echinochrome pigment extracted from sea urchin.
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Therapeutic Potential of Rhododendron arboreum Polysaccharides in an Animal Model of Lipopolysaccharide-Inflicted Oxidative Stress and Systemic Inflammation
Ajaz Ahmad,Adil Farooq Wali,Muneeb U. Rehman,A.K.Azad Khan,Mohammad Raish,Mohsin Kazi,Osamah Alnemer,Padma G M Rao +7 more
TL;DR: In this paper, the effect of Rhododendron arboreum (RAP) on inflammatory parameters in the animal model was investigated and the results indicated that RAP can benefit in the management of systemic inflammation from LPS and may have implications for a new treatment or preventive therapeutic strategies with an inflammatory component.
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Capsaicin ameliorates inflammation in a TRPV1-independent mechanism by inhibiting PKM2-LDHA-mediated Warburg effect in sepsis.
Xiang Zhang,Piao Luo,Fei Xia,Huan Tang,Jiayun Chen,Junzhe Zhang,Dan Li,Yongping Zhu,Yanqing Liu,Liwei Gu,Liuhai Zheng,Zhi-jie Li,Fan Yang,Li Dai,Fulong Liao,Chengchao Xu,Jigang Wang +16 more
TL;DR: In this article , a series of capsaicin-based probes were designed and synthesized, which permit the profiling of the target proteins of Capsaicin using activity-based protein profiling (ABPP).
References
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Jonathan S. Boomer,Kathleen To,Kathy Chang,Osamu Takasu,Dale F. Osborne,Andrew H. Walton,Traci L. Bricker,Stephen D. Jarman,Daniel Kreisel,Alexander S. Krupnick,Anil Srivastava,Paul E. Swanson,Jonathan Green,Richard S. Hotchkiss +13 more
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The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
Mervyn Singer,Clifford S. Deutschman,Christopher W. Seymour,Manu Shankar-Hari,Djillali Annane,Michael Bauer,Rinaldo Bellomo,Gordon R. Bernard,Jean-Daniel Chiche,Craig M. Coopersmith,Richard S. Hotchkiss,Mitchell M. Levy,John C. Marshall,Greg S. Martin,Steven M. Opal,Gordon D. Rubenfeld,Gordon D. Rubenfeld,Tom van der Poll,Jean Louis Vincent,Derek C. Angus +19 more