The inflammatory response in sepsis.
Markus Bosmann,Peter A. Ward +1 more
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TLDR
Recent insights into the signaling pathways in immune and phagocytic cells that underlie sepsis and SIRS are discussed and how these might be targeted for therapeutic interventions to reverse or attenuate pathways that lead to lethality during sepsi are considered.About:
This article is published in Trends in Immunology.The article was published on 2013-03-01 and is currently open access. It has received 382 citations till now. The article focuses on the topics: Systemic inflammatory response syndrome & Septic shock.read more
Citations
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Sepsis: a roadmap for future research
Jonathan Cohen,Jean Louis Vincent,Neill K. J. Adhikari,Flávia Ribeiro Machado,Derek C. Angus,Thierry Calandra,Katia Jaton,Stefano Giulieri,Julie Delaloye,Steven M. Opal,Kevin J. Tracey,Tom van der Poll,Eric Pelfrene +12 more
TL;DR: The understanding of the clinical epidemiology and management of sepsis is set out and how the present approaches might be challenged to develop a new roadmap for future research is asked.
Journal ArticleDOI
Sepsis: Current Dogma and New Perspectives
TL;DR: It is argued that it is time to delineate novel immunometabolic and neurophysiological mechanisms underlying the altered cellular bioenergetics and failure of epithelial and endothelial barriers that produce organ dysfunction and death.
Journal ArticleDOI
The immune system's role in sepsis progression, resolution, and long‐term outcome
Matthew J. Delano,Peter A. Ward +1 more
TL;DR: Efforts are focused on more clearly defining and effectively reversing the persistent immune cell dysfunction associated with long‐term sepsis mortality, which alters the innate and adaptive immune responses for sustained periods of time after clinical recovery.
Journal ArticleDOI
Sepsis-induced immune dysfunction: can immune therapies reduce mortality?
Matthew J. Delano,Peter A. Ward +1 more
TL;DR: These efforts are focused on defining and reversing the persistent immune cell dysfunction that is associated with mortality long after the acute events of sepsis have resolved.
Journal ArticleDOI
Complement in Immune and Inflammatory Disorders: Pathophysiological Mechanisms
Daniel Ricklin,John D. Lambris +1 more
TL;DR: This review provides an update about the functional and collaborative capabilities of complement, highlights major disease areas with known complement contribution, and indicates the potential for complement as a focal point in immunomodulatory strategies for treating inflammatory diseases.
References
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Cardiovascular autonomic dysfunction in systemic lupus, rheumatoid arthritis, primary Sjögren syndrome and other autoimmune diseases.
L Stojanovich,B Milovanovich,S R de Luka,D Popovich-Kuzmanovich,V Bisenich,B Djukanovich,T Randjelovich,M Krotin +7 more
TL;DR: Cardiovascular autonomic dysfunction was revealed in the majority of autoimmune patients, and no correlation was found between disease duration, clinical manifestations, cardiovascular risk factors and diseases activity on the one hand, and ANS dysfunction on the other hand.
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The Lingering Consequences of Sepsis: A Hidden Public Health Disaster?
TL;DR: This poster presents a poster presenting a probabilistic procedure to assess the pros and cons of using MRI for anterior cruciate ligament prolapse preoperatively and found it to be a viable procedure.
Journal ArticleDOI
Bench-to-bedside review: Sepsis - from the redox point of view
TL;DR: This work has applied an integrative approach in order to fuse current state-of-the-art knowledge about redox processes involving hydrogen peroxide, nitric oxide, superoxide, peroxynitrite and hydroxyl radical, which lead to mitochondrial respiratory dysfunction.
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Role of endothelial chemokines and their receptors during inflammation
Cecilia L. Speyer,Peter A. Ward +1 more
TL;DR: The role of the endothelium in mediating chemokine effects associated with wound healing, atherosclerosis, and autoimmune diseases, conditions where leukocyte recruitment and angiogenesis play a major role will be addressed.
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A comparison of critical care research funding and the financial burden of critical illness in the United States.
Craig M. Coopersmith,Hannah Wunsch,Mitchell P. Fink,Walter T. Linde-Zwirble,Keith M. Olsen,Marilyn S. Sommers,Kanwaljeet J. S. Anand,Kathryn M. Tchorz,Derek C. Angus,Clifford S. Deutschman +9 more
TL;DR: The proportion of research dollars spent on critical care research is lower than the percentage of healthcare expenditures related to critical illness, and the cost of providing critical care is higher than total U.S. healthcare spending.
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Mervyn Singer,Clifford S. Deutschman,Christopher W. Seymour,Manu Shankar-Hari,Djillali Annane,Michael Bauer,Rinaldo Bellomo,Gordon R. Bernard,Jean-Daniel Chiche,Craig M. Coopersmith,Richard S. Hotchkiss,Mitchell M. Levy,John C. Marshall,Greg S. Martin,Steven M. Opal,Gordon D. Rubenfeld,Gordon D. Rubenfeld,Tom van der Poll,Jean Louis Vincent,Derek C. Angus +19 more