The inflammatory response in sepsis.
Markus Bosmann,Peter A. Ward +1 more
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TLDR
Recent insights into the signaling pathways in immune and phagocytic cells that underlie sepsis and SIRS are discussed and how these might be targeted for therapeutic interventions to reverse or attenuate pathways that lead to lethality during sepsi are considered.About:
This article is published in Trends in Immunology.The article was published on 2013-03-01 and is currently open access. It has received 382 citations till now. The article focuses on the topics: Systemic inflammatory response syndrome & Septic shock.read more
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System-wide molecular dynamics of endothelial dysfunction in Gram-negative sepsis
TL;DR: The novel findings reported here provide a broader picture of the molecular dynamics that take place in whole organism vascular beds in Gram-negative sepsis inflammation, and can pave the way for future therapeutic strategies aimed at intervening in specific protein synthesis mechanisms of the vascular unit during acute inflammatory processes.
Journal ArticleDOI
Actualización en sepsis y choque séptico: nuevas definiciones y evaluación clínica
Daniel Martin Arsanios,Andrés Felipe Barragán,Diana Garzón,Francisco Cuervo Millán,Jazmín Pinzón,Estefan Ramos Isaza,Carlos Alberto Muñoz +6 more
TL;DR: Este articulo proporciona una revision completa of the sepsis, abarcando las nuevas definiciones, fisiopatologia and recomendaciones sobre el diagnostico y tratamiento.
Journal ArticleDOI
Selective inhibition of interleukin-1 receptor-associated kinase 1 ameliorates lipopolysaccharide-induced sepsis in mice
Bin Pan,Jun Gao,Wei Chen,Cong Liu,Longmei Shang,Mengdi Xu,Chunling Fu,Shengyun Zhu,Mingshan Niu,Kailin Xu +9 more
TL;DR: Jh-X-119-01 selectively inhibited activation of IRAK1 and protected mice from LPS-induced sepsis and showed less toxicity on macrophages comparing with a non-selective IRAK 1/4 inhibitor.
Journal ArticleDOI
SMARCB1 Promotes Ubiquitination and Degradation of NR4A3 via Direct Interaction Driven by ROS in Vascular Endothelial Cell Injury.
Bingzheng Lu,Zhu Zhu,Longxiang Sheng,Yuan Li,Yang Yang,Yupin Chen,Dongdong Xue,Yuwei Zhou,Wei Cai,Chen Chen,Cailv Wei,Dong Xu,Min Yan,Suizhen Lin,Guangmei Yan,Wei Yin +15 more
TL;DR: It is reported that NR4A3 protein abundance is decreased immensely in VEC injury induced by reoxygenation after oxygen-glucose deprivation (OGD-R), which is significantly blocked by the administration of the antioxidative steroid TRIOL.
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Is Regular Probiotic Practice Safe for Management of Sepsis
TL;DR: In this article, the beneficial or harmful effects associated with probiotic therapy in sepsis were discussed. But, probiotic use in neonatal and athymic adult mice fail to provide any beneficial effects on mortality and sepssis-induced inflammation.
References
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The Epidemiology of Sepsis in the United States from 1979 through 2000
TL;DR: The rate of sepsis due to fungal organisms increased by 207 percent, with gram-positive bacteria becoming the predominant pathogens after 1987, and the total in-hospital mortality rate fell, yet the total number of deaths continued to increase.
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The acute respiratory distress syndrome.
TL;DR: Progress has been made in understanding the mechanisms responsible for the pathogenesis and the resolution of lung injury, including the contribution of environmental and genetic factors, and on developing novel therapeutics that can facilitate and enhance lung repair.
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Immunodesign of experimental sepsis by cecal ligation and puncture.
TL;DR: Standardized procedures for inducing sepsis in mice and rats are defined by applying defined severity grades of sepsi through modulation of the position of cecal ligation.
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Immunosuppression in patients who die of sepsis and multiple organ failure.
Jonathan S. Boomer,Kathleen To,Kathy Chang,Osamu Takasu,Dale F. Osborne,Andrew H. Walton,Traci L. Bricker,Stephen D. Jarman,Daniel Kreisel,Alexander S. Krupnick,Anil Srivastava,Paul E. Swanson,Jonathan Green,Richard S. Hotchkiss +13 more
TL;DR: Patients who die in the ICU following sepsis compared with patients who die of nonsepsis etiologies have biochemical, flow cytometric, and immunohistochemical findings consistent with immunosuppression, and targeted immune-enhancing therapy may be a valid approach in selected patients with sepsi.
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The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
Mervyn Singer,Clifford S. Deutschman,Christopher W. Seymour,Manu Shankar-Hari,Djillali Annane,Michael Bauer,Rinaldo Bellomo,Gordon R. Bernard,Jean-Daniel Chiche,Craig M. Coopersmith,Richard S. Hotchkiss,Mitchell M. Levy,John C. Marshall,Greg S. Martin,Steven M. Opal,Gordon D. Rubenfeld,Gordon D. Rubenfeld,Tom van der Poll,Jean Louis Vincent,Derek C. Angus +19 more