The inflammatory response in sepsis.
Markus Bosmann,Peter A. Ward +1 more
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TLDR
Recent insights into the signaling pathways in immune and phagocytic cells that underlie sepsis and SIRS are discussed and how these might be targeted for therapeutic interventions to reverse or attenuate pathways that lead to lethality during sepsi are considered.About:
This article is published in Trends in Immunology.The article was published on 2013-03-01 and is currently open access. It has received 382 citations till now. The article focuses on the topics: Systemic inflammatory response syndrome & Septic shock.read more
Citations
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Niacin and Selenium Attenuate Sepsis-Induced Lung Injury by Up-Regulating Nuclear Factor Erythroid 2–Related Factor 2 Signaling*
Woon Yong Kwon,Gil Joon Suh,Kyung Su Kim,Yoon Sun Jung,Sung Hee Kim,Jae Seong Kim,Kyoung Min You +6 more
TL;DR: The combination therapy of niacin and selenium attenuated lung injury and improved survival during sepsis and its therapeutic benefits were associated with the synergistic activation of the glutathione redox cycle, reduction of hydrogen peroxide level, and up-regulation of nuclear factor erythroid 2–related factor 2.
Journal ArticleDOI
MFHAS1 Is Associated with Sepsis and Stimulates TLR2/NF-κB Signaling Pathway Following Negative Regulation.
TL;DR: It was shown that blood MFHAS1 was significantly elevated in sepsis patients, and MFH AS1 was more increased in mononuclear cells from septic patients, as well as the effect of MFHas1 on the TLR2 signaling pathway.
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Macrophage-Derived Iron-Bound Lipocalin-2 Correlates with Renal Recovery Markers Following Sepsis-Induced Kidney Damage.
Christina Mertens,Laura Kuchler,Anna M. Solà,Roser Guiteras,Stephan Grein,Bernhard Brüne,Andreas von Knethen,Michaela Jung +7 more
TL;DR: It is hypothesized that both the cellular source of Lcn-2 as well as its iron-load crucially adds to its biological function during sepsis-induced renal injury.
Journal ArticleDOI
miR-23b Negatively Regulates Sepsis-Induced Inflammatory Responses by Targeting ADAM10 in Human THP-1 Monocytes.
Wenying Zhang,Furong Lu,Yuliu Xie,Yao Lin,Tian Zhao,Shoubao Tao,Zhipeng Lai,Ning Wei,Ruoxuan Yang,Yiming Shao,Junbing He +10 more
TL;DR: It is demonstrated that miR-23b negatively regulated LPS-induced inflammatory responses by targeting ADAM10 and may provide potential therapeutic targets for sepsis.
Journal ArticleDOI
Role of CD146 (MCAM) in Physiological and Pathological Angiogenesis-Contribution of New Antibodies for Therapy.
Ahmad Joshkon,Ahmad Joshkon,Xavier Heim,Cléa Dubrou,Richard Bachelier,Wael Traboulsi,Jimmy Stalin,Hussein Fayyad-Kazan,Bassam Badran,Alexandrine Foucault-Bertaud,Aurélie S. Leroyer,Nathalie Bardin,Marcel Blot-Chabaud +12 more
TL;DR: In this paper, the authors reviewed the multifaceted functions of CD146 in physiological and pathological angiogenesis and summarized the interest of using monoclonal antibodies for therapeutic purposes.
References
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Jonathan S. Boomer,Kathleen To,Kathy Chang,Osamu Takasu,Dale F. Osborne,Andrew H. Walton,Traci L. Bricker,Stephen D. Jarman,Daniel Kreisel,Alexander S. Krupnick,Anil Srivastava,Paul E. Swanson,Jonathan Green,Richard S. Hotchkiss +13 more
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The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
Mervyn Singer,Clifford S. Deutschman,Christopher W. Seymour,Manu Shankar-Hari,Djillali Annane,Michael Bauer,Rinaldo Bellomo,Gordon R. Bernard,Jean-Daniel Chiche,Craig M. Coopersmith,Richard S. Hotchkiss,Mitchell M. Levy,John C. Marshall,Greg S. Martin,Steven M. Opal,Gordon D. Rubenfeld,Gordon D. Rubenfeld,Tom van der Poll,Jean Louis Vincent,Derek C. Angus +19 more