The inflammatory response in sepsis.
Markus Bosmann,Peter A. Ward +1 more
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TLDR
Recent insights into the signaling pathways in immune and phagocytic cells that underlie sepsis and SIRS are discussed and how these might be targeted for therapeutic interventions to reverse or attenuate pathways that lead to lethality during sepsi are considered.About:
This article is published in Trends in Immunology.The article was published on 2013-03-01 and is currently open access. It has received 382 citations till now. The article focuses on the topics: Systemic inflammatory response syndrome & Septic shock.read more
Citations
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Dynamic balance of pro- and anti-inflammatory signals controls disease and limits pathology.
Joseph M. Cicchese,Stephanie Evans,Caitlin Hult,Louis R. Joslyn,Timothy Wessler,Jess A. Millar,Simeone Marino,Nicholas A. Cilfone,Joshua T. Mattila,Jennifer J. Linderman,Denise E. Kirschner +10 more
TL;DR: Evidence is provided from both experimental and mathematical/computational studies to support the concept of a dynamic balance operating during persistent and other infection scenarios of tuberculosis.
Journal ArticleDOI
Could Vitamins Help in the Fight Against COVID-19?
Thomas H. Jovic,Thomas H. Jovic,Stephen R. Ali,Stephen R. Ali,Nader Ibrahim,Nader Ibrahim,Zita M. Jessop,Zita M. Jessop,Sam P. Tarassoli,Thomas D. Dobbs,Thomas D. Dobbs,Patrick Holford,Catherine A. Thornton,Iain S. Whitaker,Iain S. Whitaker +14 more
TL;DR: There are limited proven therapeutic options for the prevention and treatment of COVID-19 and there is pathophysiologic rationale for exploring the use of vitamins in this global pandemic, supported by early anecdotal reports from international groups.
Journal ArticleDOI
Muscle dysfunction in chronic obstructive pulmonary disease: update on causes and biological findings
TL;DR: Full elucidation of the specific roles of the target biological mechanisms involved in COPD muscle dysfunction is still required and will be crucial to adequately tackle with this relevant clinical problem of COPD patients in the near-future.
Journal ArticleDOI
Vitamin C-An Adjunctive Therapy for Respiratory Infection, Sepsis and COVID-19.
Patrick Holford,Anitra C. Carr,Thomas H Jovic,Thomas H Jovic,Stephen R. Ali,Stephen R. Ali,Iain S. Whitaker,Iain S. Whitaker,Paul E. Marik,A. David Smith +9 more
TL;DR: Vitamin C’s antioxidant, anti-inflammatory and immunomodulating effects make it a potential therapeutic candidate, both for the prevention and amelioration of COVID-19 infection, and as an adjunctive therapy in the critical care of CO VID-19.
Journal ArticleDOI
High-Content Quantification of Single-Cell Immune Dynamics
Michael Junkin,Alicia J. Kaestli,Zhang Cheng,Christian Jordi,Cem Albayrak,Alexander Hoffmann,Savaş Tay,Savaş Tay +7 more
TL;DR: An automated microfluidic system that delivers precisely defined dynamical inputs to individual living cells and simultaneously measures key immune parameters dynamically is developed, enabling study of previously untestable aspects of immunity by measuring time-dependent cytokine secretion and transcription factor activity from single cells stimulated with dynamic inflammatory inputs.
References
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Free radicals and antioxidants in normal physiological functions and human disease
TL;DR: Attention is focussed on the ROS/RNS-linked pathogenesis of cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases, rheumatoid arthritis, and ageing.
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The Epidemiology of Sepsis in the United States from 1979 through 2000
TL;DR: The rate of sepsis due to fungal organisms increased by 207 percent, with gram-positive bacteria becoming the predominant pathogens after 1987, and the total in-hospital mortality rate fell, yet the total number of deaths continued to increase.
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Immunodesign of experimental sepsis by cecal ligation and puncture.
TL;DR: Standardized procedures for inducing sepsis in mice and rats are defined by applying defined severity grades of sepsi through modulation of the position of cecal ligation.
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Immunosuppression in patients who die of sepsis and multiple organ failure.
Jonathan S. Boomer,Kathleen To,Kathy Chang,Osamu Takasu,Dale F. Osborne,Andrew H. Walton,Traci L. Bricker,Stephen D. Jarman,Daniel Kreisel,Alexander S. Krupnick,Anil Srivastava,Paul E. Swanson,Jonathan Green,Richard S. Hotchkiss +13 more
TL;DR: Patients who die in the ICU following sepsis compared with patients who die of nonsepsis etiologies have biochemical, flow cytometric, and immunohistochemical findings consistent with immunosuppression, and targeted immune-enhancing therapy may be a valid approach in selected patients with sepsi.
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The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
Mervyn Singer,Clifford S. Deutschman,Christopher W. Seymour,Manu Shankar-Hari,Djillali Annane,Michael Bauer,Rinaldo Bellomo,Gordon R. Bernard,Jean-Daniel Chiche,Craig M. Coopersmith,Richard S. Hotchkiss,Mitchell M. Levy,John C. Marshall,Greg S. Martin,Steven M. Opal,Gordon D. Rubenfeld,Gordon D. Rubenfeld,Tom van der Poll,Jean Louis Vincent,Derek C. Angus +19 more