The inflammatory response in sepsis.
Markus Bosmann,Peter A. Ward +1 more
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TLDR
Recent insights into the signaling pathways in immune and phagocytic cells that underlie sepsis and SIRS are discussed and how these might be targeted for therapeutic interventions to reverse or attenuate pathways that lead to lethality during sepsi are considered.About:
This article is published in Trends in Immunology.The article was published on 2013-03-01 and is currently open access. It has received 382 citations till now. The article focuses on the topics: Systemic inflammatory response syndrome & Septic shock.read more
Citations
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Trichinella spiralis Excretory-Secretory Products Protect against Polymicrobial Sepsis by Suppressing MyD88 via Mannose Receptor
TL;DR: TsES improved survival, reduced organ injury, and enhanced bacterial clearance in septic mice, suggesting that TsES-mediated protection against polymicrobial sepsis is dependent on MR, and TsES administration might be a potential therapeutic strategy for treatingsepsis.
Journal ArticleDOI
Astragaloside IV protects against polymicrobial sepsis through inhibiting inflammatory response and apoptosis of lymphocytes.
TL;DR: Treatment with astragaloside IV protected mice against polymicrobial sepsis by inhibiting inflammatory response and lymphocyte apoptosis, and might provide a novel therapeutic approach for septic patients.
Journal ArticleDOI
Physical Exercise Induces Specific Adaptations Resulting in Reduced Organ Injury and Mortality During Severe Polymicrobial Sepsis
Maik Sossdorf,Jacqueline Fischer,Stefan Meyer,Katja Dahlke,Bianka Wissuwa,Carolin Seidel,Andrea Schrepper,Clemens L. Bockmeyer,Amelie Lupp,Sophie Neugebauer,Diana Schmerler,Jürgen Rödel,Ralf A. Claus,Gordon P. Otto +13 more
TL;DR: Regular physical exercise reduces sepsis-associated acute kidney injury and death and identifies various lysophosphatidylcholines that might function as surrogate for improved outcome in sepsi.
Journal ArticleDOI
The Expression of Nuclear Transcription Factor Kappa B (NF-κB) in the Case of Critically Ill Polytrauma Patients with Sepsis and Its Interactions with microRNAs
Marius Papurica,Alexandru Florin Rogobete,Dorel Sandesc,Carmen Alina Cradigati,Mirela Sarandan,Dan C Crisan,Florin George Horhat,Ovidiu Boruga,Raluca Dumache,Kundnani Rajpal Nilima,Razvan Nitu,Horia Tudor Stanca,Ovidiu Horea Bedreag +12 more
TL;DR: The modifications seen in the expression of NF-κB in critically polytraumatized patients with sepsis are presented and the correlation between the microRNAs and its further implications in clinical status of these patients are discussed.
Journal ArticleDOI
Tyrosine kinase 2 promotes sepsis-associated lethality by facilitating production of interleukin-27.
Markus Bosmann,Birgit Strobl,Nadia Kichler,Doris Rigler,Jamison J. Grailer,Florence Pache,Peter J. Murray,Mathias Müller,Peter A. Ward +8 more
TL;DR: Tyk2 is identified as a prerequisite factor in the molecular networks that are involved in generation of IL‐27 and observed that Tyk2−/− mice have improved survival following endotoxic shock or polymicrobial sepsis induced by CLP.
References
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Journal ArticleDOI
Free radicals and antioxidants in normal physiological functions and human disease
TL;DR: Attention is focussed on the ROS/RNS-linked pathogenesis of cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases, rheumatoid arthritis, and ageing.
Journal ArticleDOI
The Epidemiology of Sepsis in the United States from 1979 through 2000
TL;DR: The rate of sepsis due to fungal organisms increased by 207 percent, with gram-positive bacteria becoming the predominant pathogens after 1987, and the total in-hospital mortality rate fell, yet the total number of deaths continued to increase.
Journal ArticleDOI
The acute respiratory distress syndrome.
TL;DR: Progress has been made in understanding the mechanisms responsible for the pathogenesis and the resolution of lung injury, including the contribution of environmental and genetic factors, and on developing novel therapeutics that can facilitate and enhance lung repair.
Journal ArticleDOI
Immunodesign of experimental sepsis by cecal ligation and puncture.
TL;DR: Standardized procedures for inducing sepsis in mice and rats are defined by applying defined severity grades of sepsi through modulation of the position of cecal ligation.
Journal ArticleDOI
Immunosuppression in patients who die of sepsis and multiple organ failure.
Jonathan S. Boomer,Kathleen To,Kathy Chang,Osamu Takasu,Dale F. Osborne,Andrew H. Walton,Traci L. Bricker,Stephen D. Jarman,Daniel Kreisel,Alexander S. Krupnick,Anil Srivastava,Paul E. Swanson,Jonathan Green,Richard S. Hotchkiss +13 more
TL;DR: Patients who die in the ICU following sepsis compared with patients who die of nonsepsis etiologies have biochemical, flow cytometric, and immunohistochemical findings consistent with immunosuppression, and targeted immune-enhancing therapy may be a valid approach in selected patients with sepsi.
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The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
Mervyn Singer,Clifford S. Deutschman,Christopher W. Seymour,Manu Shankar-Hari,Djillali Annane,Michael Bauer,Rinaldo Bellomo,Gordon R. Bernard,Jean-Daniel Chiche,Craig M. Coopersmith,Richard S. Hotchkiss,Mitchell M. Levy,John C. Marshall,Greg S. Martin,Steven M. Opal,Gordon D. Rubenfeld,Gordon D. Rubenfeld,Tom van der Poll,Jean Louis Vincent,Derek C. Angus +19 more