The inflammatory response in sepsis.
Markus Bosmann,Peter A. Ward +1 more
Reads0
Chats0
TLDR
Recent insights into the signaling pathways in immune and phagocytic cells that underlie sepsis and SIRS are discussed and how these might be targeted for therapeutic interventions to reverse or attenuate pathways that lead to lethality during sepsi are considered.About:
This article is published in Trends in Immunology.The article was published on 2013-03-01 and is currently open access. It has received 382 citations till now. The article focuses on the topics: Systemic inflammatory response syndrome & Septic shock.read more
Citations
More filters
Efeitos de bloqueadores de canais de potássio na reatividade vascular renal durante a sepse em ratos
Journal ArticleDOI
Bioprocessed polysaccharide from Lentinus edodes mycelia cultures with turmeric represses the proinflammatory cytokine expression of the porcine macrophage infected by Salmonella Choleraesuis
TL;DR: In this article, the immunomodulatory effects of BPP-turmeric on the porcine macrophage 3D4/31 cell line infected with Salmonella enterica subsp. enterica serovar Choleraesuis (S.Enteritidis) or S.Enterica serotype were examined.
Journal ArticleDOI
Lyophilized plasma resuscitation downregulates inflammatory gene expression in a mouse model of sepsis
TL;DR: Resuscitation with LP did not improve mortality or reduce permeability or injury in this model compared with LR, however, LP downregulated pulmonary inflammatory gene signaling and may also reduce circulating biomarkers of inflammation.
Journal ArticleDOI
Evaluation of the protective role of resveratrol against sepsis caused by LPS via TLR4/NF‐κB/TNF‐α signaling pathways: Experimental study
Aslı Okan,Züleyha Doğanyiğit,Seher Yilmaz,Sümeyye Uçar,Evrim Suna ARIKAN SÖYLEMEZ,Rukset Attar +5 more
TL;DR: In this paper , resveratrol has been shown to suppress the TLR4/NF-κB/TNF-α pathway in an animal model of sepsis.
Journal Article
Efek Kortikosteroid Dosis Rendah terhadap Kadar Soluble Receptor for Advanced Glycation End Products Mencit Balb/C Model Sepsis
TL;DR: Kortikosteroid dosis rendah secara bermakna menurunkan kadar sRAGE dibanding dengan kelompok sepsis yang digunakan adalah metil prednisolon dosis 0,05 mg/mencit/hari secara i.p.
References
More filters
Journal ArticleDOI
Free radicals and antioxidants in normal physiological functions and human disease
TL;DR: Attention is focussed on the ROS/RNS-linked pathogenesis of cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases, rheumatoid arthritis, and ageing.
Journal ArticleDOI
The Epidemiology of Sepsis in the United States from 1979 through 2000
TL;DR: The rate of sepsis due to fungal organisms increased by 207 percent, with gram-positive bacteria becoming the predominant pathogens after 1987, and the total in-hospital mortality rate fell, yet the total number of deaths continued to increase.
Journal ArticleDOI
The acute respiratory distress syndrome.
TL;DR: Progress has been made in understanding the mechanisms responsible for the pathogenesis and the resolution of lung injury, including the contribution of environmental and genetic factors, and on developing novel therapeutics that can facilitate and enhance lung repair.
Journal ArticleDOI
Immunodesign of experimental sepsis by cecal ligation and puncture.
TL;DR: Standardized procedures for inducing sepsis in mice and rats are defined by applying defined severity grades of sepsi through modulation of the position of cecal ligation.
Journal ArticleDOI
Immunosuppression in patients who die of sepsis and multiple organ failure.
Jonathan S. Boomer,Kathleen To,Kathy Chang,Osamu Takasu,Dale F. Osborne,Andrew H. Walton,Traci L. Bricker,Stephen D. Jarman,Daniel Kreisel,Alexander S. Krupnick,Anil Srivastava,Paul E. Swanson,Jonathan Green,Richard S. Hotchkiss +13 more
TL;DR: Patients who die in the ICU following sepsis compared with patients who die of nonsepsis etiologies have biochemical, flow cytometric, and immunohistochemical findings consistent with immunosuppression, and targeted immune-enhancing therapy may be a valid approach in selected patients with sepsi.
Related Papers (5)
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
Mervyn Singer,Clifford S. Deutschman,Christopher W. Seymour,Manu Shankar-Hari,Djillali Annane,Michael Bauer,Rinaldo Bellomo,Gordon R. Bernard,Jean-Daniel Chiche,Craig M. Coopersmith,Richard S. Hotchkiss,Mitchell M. Levy,John C. Marshall,Greg S. Martin,Steven M. Opal,Gordon D. Rubenfeld,Gordon D. Rubenfeld,Tom van der Poll,Jean Louis Vincent,Derek C. Angus +19 more