The inflammatory response in sepsis.
Markus Bosmann,Peter A. Ward +1 more
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TLDR
Recent insights into the signaling pathways in immune and phagocytic cells that underlie sepsis and SIRS are discussed and how these might be targeted for therapeutic interventions to reverse or attenuate pathways that lead to lethality during sepsi are considered.About:
This article is published in Trends in Immunology.The article was published on 2013-03-01 and is currently open access. It has received 382 citations till now. The article focuses on the topics: Systemic inflammatory response syndrome & Septic shock.read more
Citations
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TLR4 activation inhibits the proliferation and osteogenic differentiation of skeletal muscle stem cells by downregulating LGI1
TL;DR: A regulatory mechanism in SMSCs whereby LGI1 expression is reduced byTLR4, thus impeding cell proliferation and osteogenesis is revealed, highlighting TLR4 as a potential therapeutic target against many diseases related to SMSCs.
Dissertation
The role of LPCAT in regulating cellular inflammatory responses to toll-like receptor ligands
TL;DR: Evidence is provided that LPCAT influences the complex network of cell signalling involved in microbial responses, underlying it’s importance in inflammatory responses and potentially offering a target for novel anti-sepsis therapies.
Journal ArticleDOI
Validation of reference genes for the normalization of the RT-qPCR in peripheral blood mononuclear cells of septic patients.
Ruoyu Song,Shijun He,Yongbin Wu,Wanxin Chen,Jie Song,Yaxi Zhu,Huan Chen,Shouman Wang,Sichuang Tan,Sipin Tan +9 more
TL;DR: YWHAZ was the most stable gene among the 9 candidate genes evaluated by both geNorm and NormFinder in mixed and sepsis groups as mentioned in this paper , which can serve as a useful tool for gene function exploration in the future.
Journal ArticleDOI
Exploring the epidemiology of disseminated intravascular coagulation: protocol for the DANish Disseminated Intravascular Coagulation (DANDIC) Cohort Study
Simon Flæng,S. Nygaard,Asger Granfeldt,Anne-Mette Hvas,Henrik Toft Sørensen,Jecko Thachil,Kasper Adelborg +6 more
TL;DR: The DANish Disseminated Intravascular Coagulation (DANDIC) Cohort Study will aim to answer questions regarding the incidence and mortality of patients with DIC including time trends and identify prognostic factors that may guide personalised prevention and treatment.
Posted ContentDOI
A Yeast-Based Screening System for Differential Identification of Poison Inhibitors and Catalytic Inhibitors of Human Topoisomerase I
Ahmed Seddek,C. Madeira,Thirunavukkarasu Annamalai,C. Mederos,Purushottam B. Tiwari,A. Z. Welch,Yuk-Ching Tse-Dinh +6 more
TL;DR: In this paper, a yeast-based screening system was developed to identify human TOP1 poison inhibitors for anticancer efficacy as well as catalytic inhibitors that can inhibit TOP1 DNA binding or cleavage activity in steps prior to the formation of the TOP1cc.
References
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Immunosuppression in patients who die of sepsis and multiple organ failure.
Jonathan S. Boomer,Kathleen To,Kathy Chang,Osamu Takasu,Dale F. Osborne,Andrew H. Walton,Traci L. Bricker,Stephen D. Jarman,Daniel Kreisel,Alexander S. Krupnick,Anil Srivastava,Paul E. Swanson,Jonathan Green,Richard S. Hotchkiss +13 more
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Related Papers (5)
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
Mervyn Singer,Clifford S. Deutschman,Christopher W. Seymour,Manu Shankar-Hari,Djillali Annane,Michael Bauer,Rinaldo Bellomo,Gordon R. Bernard,Jean-Daniel Chiche,Craig M. Coopersmith,Richard S. Hotchkiss,Mitchell M. Levy,John C. Marshall,Greg S. Martin,Steven M. Opal,Gordon D. Rubenfeld,Gordon D. Rubenfeld,Tom van der Poll,Jean Louis Vincent,Derek C. Angus +19 more