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Journal ArticleDOI

The neurobiology of learning and memory

Richard F. Thompson
- 29 Aug 1986 - 
- Vol. 233, Iss: 4767, pp 941-947
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TLDR
Probably applications of this new understanding of the neural bases of learning and memory range from education to the treatment of learning disabilities to the design of new artificial intelligence systems.
Abstract
Study of the neurobiology of learning and memory is in a most exciting phase. Behavioral studies in animals are characterizing the categories and properties of learning and memory; essential memory trace circuits in the brain are being defined and localized in mammalian models; work on human memory and the brain is identifying neuronal systems involved in memory; the neuronal, neurochemical, molecular, and biophysical substrates of memory are beginning to be understood in both invertebrate and vertebrate systems; and theoretical and mathematical analysis of basic associative learning and of neuronal networks in proceeding apace. Likely applications of this new understanding of the neural bases of learning and memory range from education to the treatment of learning disabilities to the design of new artificial intelligence systems.

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Citations
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Journal ArticleDOI

Cerebellar function: On-line control and learning

TL;DR: The first part of Bloedel's target article reviews evidence for the organization of the cerebellum into sagittal zones and suggests that the functioning of the Cerebellum is through sagittally organized units of cells.
Journal ArticleDOI

Classical conditioning of rabbits 2-1/2 to 4 years old using mossy fiber stimulation as a CS.

TL;DR: Age differences in eyelid classical conditioning cannot be entirely attributed to changes in the peripheral CS pathway, and Changes in the nervous system occurring more centrally in the cerebellum appear to affect learning and memory.
Book

Computational Models of Conditioning

TL;DR: The complexity of the models frequently results in function redundancy, a natural property of biologically evolved systems that is much desired in technologically designed products as mentioned in this paper, which makes computer simulations irreplaceable.
Book ChapterDOI

9 – Neural Circuit for Classical Conditioning of the Eyelid Closure Response

TL;DR: Lesion and microstimulation data suggest that the essential conditioned stimulus (CS) pathway includes mossy fiber projections to the cerebellum via the pontine nuclei, and sufficiently large lesions of the middle cerebellar peduncle prevent acquisition and immediately abolish retention of the eyelid conditioned response (CR).
Journal ArticleDOI

Network models for haptic perception

TL;DR: It is concluded that combinations of these factors determine the patterns of activation in the processing networks, and describe how shape and spatial processing take place in haptic perception in the absence of visual stimulation.
References
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Journal ArticleDOI

Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.

TL;DR: The after‐effects of repetitive stimulation of the perforant path fibres to the dentate area of the hippocampal formation have been examined with extracellular micro‐electrodes in rabbits anaesthetized with urethane.
Journal ArticleDOI

A Theory of Cerebellar Cortex

TL;DR: A detailed theory of cerebellar cortex is proposed whose consequence is that the cerebellum learns to perform motor skills and two forms of input—output relation are described, both consistent with the cortical theory.
Journal ArticleDOI

A Theory of Cerebellar Function

TL;DR: It is demonstrated that, in order for the learning process to be stable, pattern storage must be accomplished principally by weakening synaptic weights rather than by strengthening them.
Journal ArticleDOI

Habituation: A model phenomenon for the study of neuronal substrates of behavior.

TL;DR: An apparatus for cleaning and sterilizing objects, such as pharmaceutical caps, plugs and the like, includes an autoclave chamber and a cleaning device having a cleaning drum mounted for a free rotation on a frame.
Journal ArticleDOI

Hippocampus, space, and memory

TL;DR: It is proposed that the hippocampus is selectively involved in behaviors that require working memory, irrespective of the type of material (spatial or nonspatial) that is to be processed by that memory.
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