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Journal ArticleDOI

The neurobiology of learning and memory

Richard F. Thompson
- 29 Aug 1986 - 
- Vol. 233, Iss: 4767, pp 941-947
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TLDR
Probably applications of this new understanding of the neural bases of learning and memory range from education to the treatment of learning disabilities to the design of new artificial intelligence systems.
Abstract
Study of the neurobiology of learning and memory is in a most exciting phase. Behavioral studies in animals are characterizing the categories and properties of learning and memory; essential memory trace circuits in the brain are being defined and localized in mammalian models; work on human memory and the brain is identifying neuronal systems involved in memory; the neuronal, neurochemical, molecular, and biophysical substrates of memory are beginning to be understood in both invertebrate and vertebrate systems; and theoretical and mathematical analysis of basic associative learning and of neuronal networks in proceeding apace. Likely applications of this new understanding of the neural bases of learning and memory range from education to the treatment of learning disabilities to the design of new artificial intelligence systems.

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Citations
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Theory and Methodology A self-organizing neural network approach for the single AGV routing problem

TL;DR: An artificial neural network algorithm based on Kohonen's self-organizing feature maps is developed to solve the special form of Automated Guided Vehicle routing problem, and several improvements on the basic features of self- Organizing maps are proposed.
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Impaired motor skills on static and mobile beams in lurcher mutant mice.

TL;DR: The results indicate that, although lurcher mutants are limited in their capacity to execute motor coordination tasks, postural sensorimotor learning is not abolished in the absence of cerebellar cortical output neurons.
Book ChapterDOI

Some Relationships Between a Computational Model (Sop) and a Neural Circuit for Pavlovian (Rabbit Eyeblink) Conditioning

TL;DR: This chapter presents an introductory-level description of the sometimes opponent process (SOP), which is an abstract model of animal learning and performance that was developed in an attempt to integrate conceptually the principal behavioral regularities of Pavlovian conditioning.
Book ChapterDOI

Functional Implications of Tonic and Phasic Activity Changes in Nucleus Basalis Neurons

TL;DR: The nucleus basalis, the largest component of the BFCS, was shown to have a substantial loss of neurons in patients with AD and the depletion of nucleus basali neurons was hypothesized to account for the decrease in cortical cholinergic markers which could possibly lead to the cognitive deterioration of AD.
Journal ArticleDOI

Concurrent conditioned taste aversion: a learning mechanism based on rapid neural versus flexible humoral processing of visceral noxious substances.

TL;DR: Two different TAL modalities, concurrent and sequential, are analyzed in the light of the recent proposal that different acquisition processes are sustained by distinct cerebral systems.
References
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Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.

TL;DR: The after‐effects of repetitive stimulation of the perforant path fibres to the dentate area of the hippocampal formation have been examined with extracellular micro‐electrodes in rabbits anaesthetized with urethane.
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A Theory of Cerebellar Cortex

TL;DR: A detailed theory of cerebellar cortex is proposed whose consequence is that the cerebellum learns to perform motor skills and two forms of input—output relation are described, both consistent with the cortical theory.
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A Theory of Cerebellar Function

TL;DR: It is demonstrated that, in order for the learning process to be stable, pattern storage must be accomplished principally by weakening synaptic weights rather than by strengthening them.
Journal ArticleDOI

Habituation: A model phenomenon for the study of neuronal substrates of behavior.

TL;DR: An apparatus for cleaning and sterilizing objects, such as pharmaceutical caps, plugs and the like, includes an autoclave chamber and a cleaning device having a cleaning drum mounted for a free rotation on a frame.
Journal ArticleDOI

Hippocampus, space, and memory

TL;DR: It is proposed that the hippocampus is selectively involved in behaviors that require working memory, irrespective of the type of material (spatial or nonspatial) that is to be processed by that memory.
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