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Journal ArticleDOI

The neurobiology of learning and memory

Richard F. Thompson
- 29 Aug 1986 - 
- Vol. 233, Iss: 4767, pp 941-947
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TLDR
Probably applications of this new understanding of the neural bases of learning and memory range from education to the treatment of learning disabilities to the design of new artificial intelligence systems.
Abstract
Study of the neurobiology of learning and memory is in a most exciting phase. Behavioral studies in animals are characterizing the categories and properties of learning and memory; essential memory trace circuits in the brain are being defined and localized in mammalian models; work on human memory and the brain is identifying neuronal systems involved in memory; the neuronal, neurochemical, molecular, and biophysical substrates of memory are beginning to be understood in both invertebrate and vertebrate systems; and theoretical and mathematical analysis of basic associative learning and of neuronal networks in proceeding apace. Likely applications of this new understanding of the neural bases of learning and memory range from education to the treatment of learning disabilities to the design of new artificial intelligence systems.

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Citations
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Visuo-tactile cross-modal associations in cortical somatosensory cells.

TL;DR: It is inferred that cells in somatosensory cortex are the components of neuronal networks representing tactile information, and Associated visual stimuli may activate such networks through visuo-haptic associations established by behavioral training.
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Inhibitory Cerebello-Olivary Projections and Blocking Effect in Classical Conditioning

TL;DR: It is suggested that the inferior olive becomes functionally inhibited by the cerebellum during conditioning, and that this negative feedback process might be the neural mechanism mediating blocking.
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Sexual dimorphism in the mammalian limbic system

TL;DR: C O N T E N T S S S as mentioned in this paper ] is a tool that can be used to measure the performance of a set of tasks. But it cannot be used for all tasks.
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Role of the cerebellum in reaching movements in humans. II. A neural model of the intermediate cerebellum.

TL;DR: The role of the cerebellum is examined by embedding a novel, detailed cerebellar neural network in a functional control model for visually guided arm movement and the role in learning to control the arm was assessed.
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The neural basis of basic associative learning of discrete behavioral responses

TL;DR: Evidence grows that the essential conditioned stimulus (CS) pathway involves mossy fiber projections and the essential unconditioned stimulus (US) pathways involves climbing fiber projections to the cerebellum, and that the Cerebellum and its associated brain stem circuitry are the essential (necessary and sufficient) neuronal substrates for this category of basic associative learning and memory.
References
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Journal ArticleDOI

Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.

TL;DR: The after‐effects of repetitive stimulation of the perforant path fibres to the dentate area of the hippocampal formation have been examined with extracellular micro‐electrodes in rabbits anaesthetized with urethane.
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A Theory of Cerebellar Cortex

TL;DR: A detailed theory of cerebellar cortex is proposed whose consequence is that the cerebellum learns to perform motor skills and two forms of input—output relation are described, both consistent with the cortical theory.
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A Theory of Cerebellar Function

TL;DR: It is demonstrated that, in order for the learning process to be stable, pattern storage must be accomplished principally by weakening synaptic weights rather than by strengthening them.
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Habituation: A model phenomenon for the study of neuronal substrates of behavior.

TL;DR: An apparatus for cleaning and sterilizing objects, such as pharmaceutical caps, plugs and the like, includes an autoclave chamber and a cleaning device having a cleaning drum mounted for a free rotation on a frame.
Journal ArticleDOI

Hippocampus, space, and memory

TL;DR: It is proposed that the hippocampus is selectively involved in behaviors that require working memory, irrespective of the type of material (spatial or nonspatial) that is to be processed by that memory.
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