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Journal ArticleDOI

The neurobiology of learning and memory

Richard F. Thompson
- 29 Aug 1986 - 
- Vol. 233, Iss: 4767, pp 941-947
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TLDR
Probably applications of this new understanding of the neural bases of learning and memory range from education to the treatment of learning disabilities to the design of new artificial intelligence systems.
Abstract
Study of the neurobiology of learning and memory is in a most exciting phase. Behavioral studies in animals are characterizing the categories and properties of learning and memory; essential memory trace circuits in the brain are being defined and localized in mammalian models; work on human memory and the brain is identifying neuronal systems involved in memory; the neuronal, neurochemical, molecular, and biophysical substrates of memory are beginning to be understood in both invertebrate and vertebrate systems; and theoretical and mathematical analysis of basic associative learning and of neuronal networks in proceeding apace. Likely applications of this new understanding of the neural bases of learning and memory range from education to the treatment of learning disabilities to the design of new artificial intelligence systems.

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Citations
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Balance dysfunction in childhood anxiety: findings and theoretical approach

TL;DR: In this paper, a small sample of children diagnosed for general or separation anxiety disorder and a control group of normal children were tested, and detailed questionnaires and balance tests confirmed an excessive sensitivity of anxiety disordered children to balance-challenging situations.
Book ChapterDOI

Chapter 22 Role of the prefrontal — thalamic axis in classical conditioning

TL;DR: The major conclusion to be drawn from the above-described research on the role of the PFCag is obviously that it plays a primary and perhaps necessary role in the establishment of visceral cues associated with exposure to classical conditioning contingencies.
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Learning to inhibit prepotent responses: successful performance by rhesus macaques, Macaca mulatta, on the reversed-contingency task

TL;DR: The present findings show that macaque monkeys can master the reversed-contingency task, confirming a previous report that macaques quickly reached a performance level of roughly 50% ‘correct’, defined as choosing the smaller amount of food, and some individuals continued to perform at that level for a protracted period of testing.
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Sensorimotor learning and retention during equilibrium tests in Purkinje cell degeneration mutant mice

TL;DR: The cerebellar cortex is critically involved in timing whole body movements during postural adjustments to a mobile beam but not to four types of immobile apparatus.
References
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Journal ArticleDOI

Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.

TL;DR: The after‐effects of repetitive stimulation of the perforant path fibres to the dentate area of the hippocampal formation have been examined with extracellular micro‐electrodes in rabbits anaesthetized with urethane.
Journal ArticleDOI

A Theory of Cerebellar Cortex

TL;DR: A detailed theory of cerebellar cortex is proposed whose consequence is that the cerebellum learns to perform motor skills and two forms of input—output relation are described, both consistent with the cortical theory.
Journal ArticleDOI

A Theory of Cerebellar Function

TL;DR: It is demonstrated that, in order for the learning process to be stable, pattern storage must be accomplished principally by weakening synaptic weights rather than by strengthening them.
Journal ArticleDOI

Habituation: A model phenomenon for the study of neuronal substrates of behavior.

TL;DR: An apparatus for cleaning and sterilizing objects, such as pharmaceutical caps, plugs and the like, includes an autoclave chamber and a cleaning device having a cleaning drum mounted for a free rotation on a frame.
Journal ArticleDOI

Hippocampus, space, and memory

TL;DR: It is proposed that the hippocampus is selectively involved in behaviors that require working memory, irrespective of the type of material (spatial or nonspatial) that is to be processed by that memory.
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