Journal ArticleDOI
The neurobiology of learning and memory
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TLDR
Probably applications of this new understanding of the neural bases of learning and memory range from education to the treatment of learning disabilities to the design of new artificial intelligence systems.Abstract:
Study of the neurobiology of learning and memory is in a most exciting phase. Behavioral studies in animals are characterizing the categories and properties of learning and memory; essential memory trace circuits in the brain are being defined and localized in mammalian models; work on human memory and the brain is identifying neuronal systems involved in memory; the neuronal, neurochemical, molecular, and biophysical substrates of memory are beginning to be understood in both invertebrate and vertebrate systems; and theoretical and mathematical analysis of basic associative learning and of neuronal networks in proceeding apace. Likely applications of this new understanding of the neural bases of learning and memory range from education to the treatment of learning disabilities to the design of new artificial intelligence systems.read more
Citations
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Cerebellar cortex and eyeblink conditioning: bilateral regulation of conditioned responses.
Agnès Gruart,Christopher H. Yeo +1 more
TL;DR: It is confirmed that unilateral lesions of lobules HVI and ansiform lobe impaired conditioned responses (CRs) previously established to an auditory conditioned stimulus, but did not prevent some relearning with post-operative retraining.
Journal ArticleDOI
Biochemistry of information storage in the nervous system.
Ira B. Black,Joshua E. Adler,Cheryl F. Dreyfus,Wilma F. Friedman,E F Lagamma,Arthur H. Roach +5 more
TL;DR: Generally, transmitters, the agents of millisecond-to-millisecond communication, are subject to relatively long-lasting changes in expression, ensuring that ongoing physiological function is translated into information storage.
Journal ArticleDOI
Neurophysiological model of tinnitus: Dependence of the minimal masking level on treatment outcome
TL;DR: The psychoacoustical description of tinnitus does not possess a predictive value for the outcome of the treatment, and intensity match and threshold of hearing did not exhibit any significant changes which can be related to treatment outcome.
Journal ArticleDOI
Brain spectrin, calpain and long-term changes in synaptic efficacy.
Gary Lynch,Michel Baudry +1 more
TL;DR: This chapter discusses the possibility that proteolytic digestion of cytoskeletal proteins, in particular spectrin, is part of the mechanisms through which physiological activity elicits structural and chemical changes in brain synapses.
Journal ArticleDOI
Cerebellar aminergic neuromodulation: towards a functional understanding
TL;DR: It is shown that a number of modulatory signals are needed for powerful cerebellar learning and control and it is proposed that serotonin controls the 'responsibility' of each Cerebellar unit (or microcomplex) in cerebellary learning andControl.
References
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Timothy V. P. Bliss,T. Lømo +1 more
TL;DR: The after‐effects of repetitive stimulation of the perforant path fibres to the dentate area of the hippocampal formation have been examined with extracellular micro‐electrodes in rabbits anaesthetized with urethane.
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A Theory of Cerebellar Cortex
TL;DR: A detailed theory of cerebellar cortex is proposed whose consequence is that the cerebellum learns to perform motor skills and two forms of input—output relation are described, both consistent with the cortical theory.
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A Theory of Cerebellar Function
TL;DR: It is demonstrated that, in order for the learning process to be stable, pattern storage must be accomplished principally by weakening synaptic weights rather than by strengthening them.
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Habituation: A model phenomenon for the study of neuronal substrates of behavior.
TL;DR: An apparatus for cleaning and sterilizing objects, such as pharmaceutical caps, plugs and the like, includes an autoclave chamber and a cleaning device having a cleaning drum mounted for a free rotation on a frame.
Journal ArticleDOI
Hippocampus, space, and memory
TL;DR: It is proposed that the hippocampus is selectively involved in behaviors that require working memory, irrespective of the type of material (spatial or nonspatial) that is to be processed by that memory.