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Journal ArticleDOI

The neurobiology of learning and memory

Richard F. Thompson
- 29 Aug 1986 - 
- Vol. 233, Iss: 4767, pp 941-947
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TLDR
Probably applications of this new understanding of the neural bases of learning and memory range from education to the treatment of learning disabilities to the design of new artificial intelligence systems.
Abstract
Study of the neurobiology of learning and memory is in a most exciting phase. Behavioral studies in animals are characterizing the categories and properties of learning and memory; essential memory trace circuits in the brain are being defined and localized in mammalian models; work on human memory and the brain is identifying neuronal systems involved in memory; the neuronal, neurochemical, molecular, and biophysical substrates of memory are beginning to be understood in both invertebrate and vertebrate systems; and theoretical and mathematical analysis of basic associative learning and of neuronal networks in proceeding apace. Likely applications of this new understanding of the neural bases of learning and memory range from education to the treatment of learning disabilities to the design of new artificial intelligence systems.

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Citations
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Molecular specificity of synaptic changes responsible for associative memory.

TL;DR: A new signalling protein is described, Calexcitin, which powerfully and specifically regulates synaptic weight as well as synaptic sign and is activated by a molecular cascade more directly implicated in associative learning of diverse molluscan and mammalian species.
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Spatial orientation deficit in children due to cerebellum astrocytoma pediatric tumor obtained by means of the Attentional Network Test.

TL;DR: Children operated on for cerebellar astrocytoma showed a mild attentional deficit in the orientation network, using an attentional paradigm with theoretical and clinical bases: the Attentional Network Test (ANT).

La biosemiótica y la biología cognitiva en organismos sin sistema nervioso

TL;DR: The biosemiotic cognitive foundations within slime molds and bacteria are studied in order to establish a possible phenomenological biology, based on the measurement of minimal perception thresholds.
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Reconstructive and reproductive models of memory

TL;DR: The adequacy of reconstructive and reproductive models of memory has been in dispute ever since Bartlett's (1932) publication of his volume Remembering as mentioned in this paper, which suggested that to be adequate, an explanation of verbal memory should focus on a memory classification based on behavioral measures.
Book ChapterDOI

Functional MRI Studies of Eyeblink Classical Conditioning

TL;DR: The imaging technique of fMRI has a number of advantages over other brain imaging techniques that results in physiological images of the best possible spatial and temporal resolution, coupled with the precision possible from the large data base on the neural basis of eyeblink classical conditioning.
References
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Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.

TL;DR: The after‐effects of repetitive stimulation of the perforant path fibres to the dentate area of the hippocampal formation have been examined with extracellular micro‐electrodes in rabbits anaesthetized with urethane.
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A Theory of Cerebellar Cortex

TL;DR: A detailed theory of cerebellar cortex is proposed whose consequence is that the cerebellum learns to perform motor skills and two forms of input—output relation are described, both consistent with the cortical theory.
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A Theory of Cerebellar Function

TL;DR: It is demonstrated that, in order for the learning process to be stable, pattern storage must be accomplished principally by weakening synaptic weights rather than by strengthening them.
Journal ArticleDOI

Habituation: A model phenomenon for the study of neuronal substrates of behavior.

TL;DR: An apparatus for cleaning and sterilizing objects, such as pharmaceutical caps, plugs and the like, includes an autoclave chamber and a cleaning device having a cleaning drum mounted for a free rotation on a frame.
Journal ArticleDOI

Hippocampus, space, and memory

TL;DR: It is proposed that the hippocampus is selectively involved in behaviors that require working memory, irrespective of the type of material (spatial or nonspatial) that is to be processed by that memory.
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