Journal ArticleDOI
The neurobiology of learning and memory
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TLDR
Probably applications of this new understanding of the neural bases of learning and memory range from education to the treatment of learning disabilities to the design of new artificial intelligence systems.Abstract:
Study of the neurobiology of learning and memory is in a most exciting phase. Behavioral studies in animals are characterizing the categories and properties of learning and memory; essential memory trace circuits in the brain are being defined and localized in mammalian models; work on human memory and the brain is identifying neuronal systems involved in memory; the neuronal, neurochemical, molecular, and biophysical substrates of memory are beginning to be understood in both invertebrate and vertebrate systems; and theoretical and mathematical analysis of basic associative learning and of neuronal networks in proceeding apace. Likely applications of this new understanding of the neural bases of learning and memory range from education to the treatment of learning disabilities to the design of new artificial intelligence systems.read more
Citations
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Eyeblink conditioning in the developing rat.
TL;DR: Long-Evans rat pups, 17-18 or 24 days of age, were trained with an eyeblink conditioning procedure that was used previously with adult rats, and it was established that this effect is associative and can be modulated by motivational state.
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Long-term potentiations in vertebrate synapses: a variety of cascades with common subprocesses.
Kenji Kuba,Eiichi Kumamoto +1 more
TL;DR: Article de synthese sur la potentialisation a long terme de la transmission synaptique dans des synapses des systemes nerveux central and peripherique chez les vertebres.
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Images of the mind: studies with modern imaging techniques
TL;DR: Theoretical Implications of Constituent Anatomy: Non-Automatic Circuit and Practical and theoretical Implications are presented.
Journal ArticleDOI
Impaired Motor Function in Mice With Cell-Specific Knockout of Sodium Channel Scn8a (NaV1.6) in Cerebellar Purkinje Neurons and Granule Cells
Stephen I. Levin,Zayd M. Khaliq,Teresa K. Aman,Tina M. Grieco,Jennifer A. Kearney,Indira M. Raman,Miriam H. Meisler +6 more
TL;DR: The loss of voltage-gated Na channel alpha subunit Na(V)1.6 leads to a decrease in Purkinje cell firing rates as well as a modification of the synaptic properties of afferent parallel fibers, with the ultimate consequence of disrupting motor behavior.
Journal ArticleDOI
Testing neural network models of memory with behavioral experiments.
TL;DR: Evidence suggests that indeed specific subregions of the hippocampus may subserve different computational functions, such as spatial and temporal pattern separation, short-term or working memory, pattern association, and temporal patterns completion.
References
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Journal ArticleDOI
Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.
Timothy V. P. Bliss,T. Lømo +1 more
TL;DR: The after‐effects of repetitive stimulation of the perforant path fibres to the dentate area of the hippocampal formation have been examined with extracellular micro‐electrodes in rabbits anaesthetized with urethane.
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A Theory of Cerebellar Cortex
TL;DR: A detailed theory of cerebellar cortex is proposed whose consequence is that the cerebellum learns to perform motor skills and two forms of input—output relation are described, both consistent with the cortical theory.
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A Theory of Cerebellar Function
TL;DR: It is demonstrated that, in order for the learning process to be stable, pattern storage must be accomplished principally by weakening synaptic weights rather than by strengthening them.
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Habituation: A model phenomenon for the study of neuronal substrates of behavior.
TL;DR: An apparatus for cleaning and sterilizing objects, such as pharmaceutical caps, plugs and the like, includes an autoclave chamber and a cleaning device having a cleaning drum mounted for a free rotation on a frame.
Journal ArticleDOI
Hippocampus, space, and memory
TL;DR: It is proposed that the hippocampus is selectively involved in behaviors that require working memory, irrespective of the type of material (spatial or nonspatial) that is to be processed by that memory.