Journal ArticleDOI
The neurobiology of learning and memory
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TLDR
Probably applications of this new understanding of the neural bases of learning and memory range from education to the treatment of learning disabilities to the design of new artificial intelligence systems.Abstract:
Study of the neurobiology of learning and memory is in a most exciting phase. Behavioral studies in animals are characterizing the categories and properties of learning and memory; essential memory trace circuits in the brain are being defined and localized in mammalian models; work on human memory and the brain is identifying neuronal systems involved in memory; the neuronal, neurochemical, molecular, and biophysical substrates of memory are beginning to be understood in both invertebrate and vertebrate systems; and theoretical and mathematical analysis of basic associative learning and of neuronal networks in proceeding apace. Likely applications of this new understanding of the neural bases of learning and memory range from education to the treatment of learning disabilities to the design of new artificial intelligence systems.read more
Citations
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Mode of induction of long-term depression at parallel fibre—Purkinje cell synapses in rabbit cerebellar cortex
Masanobu Kano,Makoto Kato +1 more
TL;DR: It is suggested that the occurrence of long-term depression is strictly dependent on conjunction of climbing fibre activity with quisqualate receptor activation, and that this effect was abolished when spontaneous activity of climbing fibres was blocked by injection of tetrodotoxin or lidocaine.
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Long-Term Potentiation of Glial Synaptic Currents in Cerebellar Culture
TL;DR: Using cell-pair recording in cerebellar cultures from embryonic mouse, it is shown that activation of a granule neuron can give rise to a rapid inward current in an adjacent glial cell, suggesting a model in which cerebellary LTP is both induced and expressed presynaptically and therefore may be detected by either neuronal or glial postsynaptic cells.
Journal ArticleDOI
Does cerebellar LTD mediate motor learning? Toward a resolution without a smoking gun
TL;DR: Despite the work remaining to be done, the evidence linking LTD to motor learning is better established than for many other form of plasticity in the vertebrate nervous system.
Journal ArticleDOI
Evidence of plasticity in the pontocerebellar conditioned stimulus pathway during classical conditioning of the eyeblink response in the rabbit.
TL;DR: Electrical stimulation thresholds required to elicit eyeblinks with either pontine or cerebellar interpositus stimulation were measured before and after classical eyeblink conditioning with paired pontine stimulation (conditioned stimulus, CS) and corneal airpuff.
References
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Journal ArticleDOI
Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.
Timothy V. P. Bliss,T. Lømo +1 more
TL;DR: The after‐effects of repetitive stimulation of the perforant path fibres to the dentate area of the hippocampal formation have been examined with extracellular micro‐electrodes in rabbits anaesthetized with urethane.
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A Theory of Cerebellar Cortex
TL;DR: A detailed theory of cerebellar cortex is proposed whose consequence is that the cerebellum learns to perform motor skills and two forms of input—output relation are described, both consistent with the cortical theory.
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A Theory of Cerebellar Function
TL;DR: It is demonstrated that, in order for the learning process to be stable, pattern storage must be accomplished principally by weakening synaptic weights rather than by strengthening them.
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Habituation: A model phenomenon for the study of neuronal substrates of behavior.
TL;DR: An apparatus for cleaning and sterilizing objects, such as pharmaceutical caps, plugs and the like, includes an autoclave chamber and a cleaning device having a cleaning drum mounted for a free rotation on a frame.
Journal ArticleDOI
Hippocampus, space, and memory
TL;DR: It is proposed that the hippocampus is selectively involved in behaviors that require working memory, irrespective of the type of material (spatial or nonspatial) that is to be processed by that memory.