Journal ArticleDOI
The neurobiology of learning and memory
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TLDR
Probably applications of this new understanding of the neural bases of learning and memory range from education to the treatment of learning disabilities to the design of new artificial intelligence systems.Abstract:
Study of the neurobiology of learning and memory is in a most exciting phase. Behavioral studies in animals are characterizing the categories and properties of learning and memory; essential memory trace circuits in the brain are being defined and localized in mammalian models; work on human memory and the brain is identifying neuronal systems involved in memory; the neuronal, neurochemical, molecular, and biophysical substrates of memory are beginning to be understood in both invertebrate and vertebrate systems; and theoretical and mathematical analysis of basic associative learning and of neuronal networks in proceeding apace. Likely applications of this new understanding of the neural bases of learning and memory range from education to the treatment of learning disabilities to the design of new artificial intelligence systems.read more
Citations
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Journal ArticleDOI
Vasopressin induction of long-lasting potentiation of synaptic transmission in the dentate gyrus.
TL;DR: It is demonstrated that vasopressin can induce long‐lasting changes in the excitability of dentate gyrus neurons that are both calcium‐dependent and receptor‐specific.
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Eyeblink conditioning, motor control, and the analysis of limbic-cerebellar interactions.
Craig Weiss,John F. Disterhoft +1 more
TL;DR: In this article, the authors present some of their data on olivo-cerebellar and limbic-cerebellar interactions during eyeblink conditioning during associative learning.
Journal ArticleDOI
Learning Induces a CDC2-Related Protein Kinase, KKIAMRE
Hiroshi Gomi,Hiroshi Gomi,William Sun,Caleb E. Finch,Shigeyoshi Itohara,Kenji Yoshimi,Richard F. Thompson +6 more
TL;DR: There is a new category of cdc2-related kinases in the brain whose function may be important in learning and memory, and expression of mRNAs in brains of rabbits undergoing eyeblink conditioning is analyzed.
Journal ArticleDOI
Reflex facilitation of the nictitating membrane response remains after cerebellar lesions.
TL;DR: Reflex facilitation was shown to decrement in a stimulus-specific manner when nonreinforced presentations of an auditory stimulus were given and the relation between reflex facilitation and classical conditioning in terms of behavioral properties and underlying neural systems was focused on.
Journal ArticleDOI
Adequacy of maternal iron status protects against behavioral, neuroanatomical, and growth deficits in fetal alcohol spectrum disorders
Echoleah S. Rufer,Tuan D. Tran,Megan M. Attridge,Matthew E. Andrzejewski,George R. Flentke,Susan M. Smith +5 more
TL;DR: It is proposed that increased attention to normalizing maternal iron status will substantially improve FASD outcome, even if maternal alcohol abuse continues, and novel insights into how alcohol damages the developing brain are offered.
References
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Journal ArticleDOI
Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.
Timothy V. P. Bliss,T. Lømo +1 more
TL;DR: The after‐effects of repetitive stimulation of the perforant path fibres to the dentate area of the hippocampal formation have been examined with extracellular micro‐electrodes in rabbits anaesthetized with urethane.
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A Theory of Cerebellar Cortex
TL;DR: A detailed theory of cerebellar cortex is proposed whose consequence is that the cerebellum learns to perform motor skills and two forms of input—output relation are described, both consistent with the cortical theory.
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A Theory of Cerebellar Function
TL;DR: It is demonstrated that, in order for the learning process to be stable, pattern storage must be accomplished principally by weakening synaptic weights rather than by strengthening them.
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Habituation: A model phenomenon for the study of neuronal substrates of behavior.
TL;DR: An apparatus for cleaning and sterilizing objects, such as pharmaceutical caps, plugs and the like, includes an autoclave chamber and a cleaning device having a cleaning drum mounted for a free rotation on a frame.
Journal ArticleDOI
Hippocampus, space, and memory
TL;DR: It is proposed that the hippocampus is selectively involved in behaviors that require working memory, irrespective of the type of material (spatial or nonspatial) that is to be processed by that memory.