Journal ArticleDOI
The neurobiology of learning and memory
Reads0
Chats0
TLDR
Probably applications of this new understanding of the neural bases of learning and memory range from education to the treatment of learning disabilities to the design of new artificial intelligence systems.Abstract:
Study of the neurobiology of learning and memory is in a most exciting phase. Behavioral studies in animals are characterizing the categories and properties of learning and memory; essential memory trace circuits in the brain are being defined and localized in mammalian models; work on human memory and the brain is identifying neuronal systems involved in memory; the neuronal, neurochemical, molecular, and biophysical substrates of memory are beginning to be understood in both invertebrate and vertebrate systems; and theoretical and mathematical analysis of basic associative learning and of neuronal networks in proceeding apace. Likely applications of this new understanding of the neural bases of learning and memory range from education to the treatment of learning disabilities to the design of new artificial intelligence systems.read more
Citations
More filters
Journal ArticleDOI
Pharmacological analysis of cerebellar contributions to the timing and expression of conditioned eyelid responses
Keith S. Garcia,Michael D. Mauk +1 more
TL;DR: Reversibly blocking cerebellar cortex output via infusion of the GABA antagonist picrotoxin into the interpositus nucleus shows consistency with the hypothesis that plasticity in the interPOSitus nucleus contributes to the expression of conditioned responses, as suggested by the responses seen with the cortex disconnected.
Journal ArticleDOI
Multiple memory systems, development and conditioning
TL;DR: This article showed that the functional development of the affective system (conditioned fear response) precedes that of the sensorimotor system and that modulation of these two systems by cognitive processes also seems to emerge at different points in ontogeny.
Journal ArticleDOI
Galantamine: Effect on nicotinic receptor binding, acetylcholinesterase inhibition, and learning
TL;DR: The efficacy of Gal in a learning paradigm severely impaired in AD is consistent with outcomes in clinical studies and the drug was tested in two preclinical experiments.
Journal ArticleDOI
Limitations in anti-obesity drug development: the critical role of hunger-promoting neurons
TL;DR: Targeting the molecular pathways that mediate the beneficial effects of calorie restriction and exercise may represent an alternative therapeutic approach for the treatment of chronic metabolic disorders such as obesity.
Journal ArticleDOI
Multiple brain-memory systems: the whole does not equal the sum of its parts
Jeansok J. Kim,Mark G. Baxter +1 more
TL;DR: Consideration of interactions among multiple memory systems will enhance the current understanding of memory by encouraging the view that memory systems are dynamic interactive units, rather than independent modules that act in isolation.
References
More filters
Journal ArticleDOI
Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.
Timothy V. P. Bliss,T. Lømo +1 more
TL;DR: The after‐effects of repetitive stimulation of the perforant path fibres to the dentate area of the hippocampal formation have been examined with extracellular micro‐electrodes in rabbits anaesthetized with urethane.
Journal ArticleDOI
A Theory of Cerebellar Cortex
TL;DR: A detailed theory of cerebellar cortex is proposed whose consequence is that the cerebellum learns to perform motor skills and two forms of input—output relation are described, both consistent with the cortical theory.
Journal ArticleDOI
A Theory of Cerebellar Function
TL;DR: It is demonstrated that, in order for the learning process to be stable, pattern storage must be accomplished principally by weakening synaptic weights rather than by strengthening them.
Journal ArticleDOI
Habituation: A model phenomenon for the study of neuronal substrates of behavior.
TL;DR: An apparatus for cleaning and sterilizing objects, such as pharmaceutical caps, plugs and the like, includes an autoclave chamber and a cleaning device having a cleaning drum mounted for a free rotation on a frame.
Journal ArticleDOI
Hippocampus, space, and memory
TL;DR: It is proposed that the hippocampus is selectively involved in behaviors that require working memory, irrespective of the type of material (spatial or nonspatial) that is to be processed by that memory.