Journal ArticleDOI
The neurobiology of learning and memory
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TLDR
Probably applications of this new understanding of the neural bases of learning and memory range from education to the treatment of learning disabilities to the design of new artificial intelligence systems.Abstract:
Study of the neurobiology of learning and memory is in a most exciting phase. Behavioral studies in animals are characterizing the categories and properties of learning and memory; essential memory trace circuits in the brain are being defined and localized in mammalian models; work on human memory and the brain is identifying neuronal systems involved in memory; the neuronal, neurochemical, molecular, and biophysical substrates of memory are beginning to be understood in both invertebrate and vertebrate systems; and theoretical and mathematical analysis of basic associative learning and of neuronal networks in proceeding apace. Likely applications of this new understanding of the neural bases of learning and memory range from education to the treatment of learning disabilities to the design of new artificial intelligence systems.read more
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Book ChapterDOI
Neurobiological Views of Memory
TL;DR: This chapter presents a number of different theoretical views of the structural organization of memory at different levels of analysis and an attempt has been made to integrate all the different theoretical approaches and views into a single multidimensional attribute model of memory.
Book ChapterDOI
Chapter 23 Functions of anterior and posterior cingulate cortex during avoidance learning in rabbits
TL;DR: This chapter focuses on the functions of anterior and posterior cingulate cortex during avoidance learning in rabbits, a theoretical model of the neuronal plasticity and dynamic information flow underlying conditioned response (CR) acquisition and performance.
Journal ArticleDOI
Properties of vertebrate glutamate receptors: calcium mobilization and desensitization.
Charles F. Zorumski,Liu Lin Thio +1 more
TL;DR: Rapid desensitization appears to be one factor determining the time course and efficacy of fast excitatory synaptic transmission mediated by AMPA receptors, highlighting the physiological relevance of the process.
Journal ArticleDOI
Learning-specific differences in Purkinje-cell dendrites of lobule HVI (Lobulus simplex): intracellular recording in a rabbit cerebellar slice.
TL;DR: It is reported that intracellular recording in a slice of rabbit cerebellar lobule HVI revealed a conditioning-specific increase in the excitability of Purkinje-cell dendrites without significant changes in dendritic membrane potential or input resistance.
Book ChapterDOI
Can sense be made of spinal interneuron circuits
TL;DR: The flexion reflex system is discussed as an example of the flexibility of spinal interneuron systems and as a useful conceptual construct and examples are provided of the kinds of experiments that can be developed using current approaches to spinal Interneuronal systems.
References
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Journal ArticleDOI
Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.
Timothy V. P. Bliss,T. Lømo +1 more
TL;DR: The after‐effects of repetitive stimulation of the perforant path fibres to the dentate area of the hippocampal formation have been examined with extracellular micro‐electrodes in rabbits anaesthetized with urethane.
Journal ArticleDOI
A Theory of Cerebellar Cortex
TL;DR: A detailed theory of cerebellar cortex is proposed whose consequence is that the cerebellum learns to perform motor skills and two forms of input—output relation are described, both consistent with the cortical theory.
Journal ArticleDOI
A Theory of Cerebellar Function
TL;DR: It is demonstrated that, in order for the learning process to be stable, pattern storage must be accomplished principally by weakening synaptic weights rather than by strengthening them.
Journal ArticleDOI
Habituation: A model phenomenon for the study of neuronal substrates of behavior.
TL;DR: An apparatus for cleaning and sterilizing objects, such as pharmaceutical caps, plugs and the like, includes an autoclave chamber and a cleaning device having a cleaning drum mounted for a free rotation on a frame.
Journal ArticleDOI
Hippocampus, space, and memory
TL;DR: It is proposed that the hippocampus is selectively involved in behaviors that require working memory, irrespective of the type of material (spatial or nonspatial) that is to be processed by that memory.