Journal ArticleDOI
The neurobiology of learning and memory
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TLDR
Probably applications of this new understanding of the neural bases of learning and memory range from education to the treatment of learning disabilities to the design of new artificial intelligence systems.Abstract:
Study of the neurobiology of learning and memory is in a most exciting phase. Behavioral studies in animals are characterizing the categories and properties of learning and memory; essential memory trace circuits in the brain are being defined and localized in mammalian models; work on human memory and the brain is identifying neuronal systems involved in memory; the neuronal, neurochemical, molecular, and biophysical substrates of memory are beginning to be understood in both invertebrate and vertebrate systems; and theoretical and mathematical analysis of basic associative learning and of neuronal networks in proceeding apace. Likely applications of this new understanding of the neural bases of learning and memory range from education to the treatment of learning disabilities to the design of new artificial intelligence systems.read more
Citations
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Journal ArticleDOI
Eyeblink classical conditioning to auditory and olfactory stimuli: performance among older adults with and without the apolipoprotein E epsilon 4 allele.
TL;DR: Results support olfactory compromise in the earliest stages of the AD disease process as changes in the rate of CR acquisition were apparent in nondemented older adults at greater genetic risk for developing AD.
Book ChapterDOI
Alcohol-Induced Damage to the Developing Brain: Functional Approaches Using Classical Eyeblink Conditioning
Journal ArticleDOI
Evolutionary expression of the neuronal form of the src protein in the brain
TL;DR: Findings indicate that pp60c-src+ may play a role in events associated with higher brain function, such as neuronal plasticity, as well as evolutionary conservation of the 6-amino acid insert.
Journal ArticleDOI
Silent Trace Eliminates Differential Eyeblink Learning in Abstinent Alcoholics
Catherine Fortier,Arkadiy L. Maksimovskiy,Jonathan R. Venne,Ginette Lafleche,Regina E. McGlinchey +4 more
TL;DR: Data support the notion that alcoholics are increasingly impaired in the complex task of reversing a previously learned discrimination when a silent trace interval is introduced and impairment in flexibly altering learned associations may be central to their continued addiction.
References
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Journal ArticleDOI
Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.
Timothy V. P. Bliss,T. Lømo +1 more
TL;DR: The after‐effects of repetitive stimulation of the perforant path fibres to the dentate area of the hippocampal formation have been examined with extracellular micro‐electrodes in rabbits anaesthetized with urethane.
Journal ArticleDOI
A Theory of Cerebellar Cortex
TL;DR: A detailed theory of cerebellar cortex is proposed whose consequence is that the cerebellum learns to perform motor skills and two forms of input—output relation are described, both consistent with the cortical theory.
Journal ArticleDOI
A Theory of Cerebellar Function
TL;DR: It is demonstrated that, in order for the learning process to be stable, pattern storage must be accomplished principally by weakening synaptic weights rather than by strengthening them.
Journal ArticleDOI
Habituation: A model phenomenon for the study of neuronal substrates of behavior.
TL;DR: An apparatus for cleaning and sterilizing objects, such as pharmaceutical caps, plugs and the like, includes an autoclave chamber and a cleaning device having a cleaning drum mounted for a free rotation on a frame.
Journal ArticleDOI
Hippocampus, space, and memory
TL;DR: It is proposed that the hippocampus is selectively involved in behaviors that require working memory, irrespective of the type of material (spatial or nonspatial) that is to be processed by that memory.