Journal ArticleDOI
The neurobiology of learning and memory
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TLDR
Probably applications of this new understanding of the neural bases of learning and memory range from education to the treatment of learning disabilities to the design of new artificial intelligence systems.Abstract:
Study of the neurobiology of learning and memory is in a most exciting phase. Behavioral studies in animals are characterizing the categories and properties of learning and memory; essential memory trace circuits in the brain are being defined and localized in mammalian models; work on human memory and the brain is identifying neuronal systems involved in memory; the neuronal, neurochemical, molecular, and biophysical substrates of memory are beginning to be understood in both invertebrate and vertebrate systems; and theoretical and mathematical analysis of basic associative learning and of neuronal networks in proceeding apace. Likely applications of this new understanding of the neural bases of learning and memory range from education to the treatment of learning disabilities to the design of new artificial intelligence systems.read more
Citations
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Posted ContentDOI
The neural basis of tadpole transport in poison frogs
Eva K. Fischer,Alexandre B. Roland,Nora A. Moskowitz,Elicio Tapia,Kyle Summers,Luis A. Coloma,Lauren A. O’Connell +6 more
TL;DR: This work took advantage of behavioral diversity across closely related species of South American poison frogs to identify neural correlates of parental behavior shared across sexes and species, and identified the medial pallium and preoptic area as core brain regions associated with parental care, independent of sex and species.
Journal ArticleDOI
The Biology of Personality
TL;DR: Challenges to this assumption of the overwhelming importance of life experiences are reviewed and Cloninger's tridimensional theory of personality is presented as a model which attempts to bridge the gap between theoretical temperamental traits, neurotransmitter function and clinical psychiatry.
Journal ArticleDOI
Purkinje cell loss by OX7-saporin impairs excitatory and inhibitory eyeblink conditioning.
Brian C. Nolan,John H. Freeman +1 more
TL;DR: It is suggested that Purkinje cells play important, but different, roles in conditioned excitation and inhibition in rats, as shown in rats treated with OX7-saporin.
Book ChapterDOI
Inferior olive hypertrophy and cerebellar learning are both needed to explain ocular oscillations in oculopalatal tremor.
TL;DR: Variable pendular ocular oscillations emerged from the cerebellum model after learning this association between IO pulse trains on mossy and climbing fibres in PC and electrotonic coupling of IO cells depends on connexin proteins.
Journal ArticleDOI
Cerebellum-Specific Deletion of the GABAA Receptor δ Subunit Leads to Sex-Specific Disruption of Behavior.
Stephanie Rudolph,Chong Guo,Stan L. Pashkovski,Tomas Osorno,Winthrop F. Gillis,Jeremy M. Krauss,Hajnalka Nyitrai,Isabella Flaquer,Mahmoud El-Rifai,Sandeep Robert Datta,Wade G. Regehr +10 more
TL;DR: It is found that GC-specific deletion of δGABAA (cerebellar [cb] δ knockout [KO]) decreases tonic inhibition, makes GCs hyperexcitable, and in turn, leads to differential activation of cb output regions as well as many cortical and subcortical brain areas involved in cognition, anxiety-like behaviors, and the stress response.
References
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Timothy V. P. Bliss,T. Lømo +1 more
TL;DR: The after‐effects of repetitive stimulation of the perforant path fibres to the dentate area of the hippocampal formation have been examined with extracellular micro‐electrodes in rabbits anaesthetized with urethane.
Journal ArticleDOI
A Theory of Cerebellar Cortex
TL;DR: A detailed theory of cerebellar cortex is proposed whose consequence is that the cerebellum learns to perform motor skills and two forms of input—output relation are described, both consistent with the cortical theory.
Journal ArticleDOI
A Theory of Cerebellar Function
TL;DR: It is demonstrated that, in order for the learning process to be stable, pattern storage must be accomplished principally by weakening synaptic weights rather than by strengthening them.
Journal ArticleDOI
Habituation: A model phenomenon for the study of neuronal substrates of behavior.
TL;DR: An apparatus for cleaning and sterilizing objects, such as pharmaceutical caps, plugs and the like, includes an autoclave chamber and a cleaning device having a cleaning drum mounted for a free rotation on a frame.
Journal ArticleDOI
Hippocampus, space, and memory
TL;DR: It is proposed that the hippocampus is selectively involved in behaviors that require working memory, irrespective of the type of material (spatial or nonspatial) that is to be processed by that memory.