Journal ArticleDOI
The neurobiology of learning and memory
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TLDR
Probably applications of this new understanding of the neural bases of learning and memory range from education to the treatment of learning disabilities to the design of new artificial intelligence systems.Abstract:
Study of the neurobiology of learning and memory is in a most exciting phase. Behavioral studies in animals are characterizing the categories and properties of learning and memory; essential memory trace circuits in the brain are being defined and localized in mammalian models; work on human memory and the brain is identifying neuronal systems involved in memory; the neuronal, neurochemical, molecular, and biophysical substrates of memory are beginning to be understood in both invertebrate and vertebrate systems; and theoretical and mathematical analysis of basic associative learning and of neuronal networks in proceeding apace. Likely applications of this new understanding of the neural bases of learning and memory range from education to the treatment of learning disabilities to the design of new artificial intelligence systems.read more
Citations
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Journal ArticleDOI
Cerebellar involvement in eyeblink classical conditioning in humans.
TL;DR: The role of the ipsilateral cerebellum in human eyeblink conditioning was investigated using the 400-ms delay paradigm and testing 14 cerebellar patients (7 with unilateral lesions and 7 with bilateral lesions) and 20 control participants as discussed by the authors.
Journal ArticleDOI
Simulations of cerebellar motor learning: Computational analysis of plasticity at the mossy fiber to deep nucleus synapse
Javier F. Medina,Michael D. Mauk +1 more
TL;DR: It is shown that learning and memory require that these cellular mechanisms be correctly integrated within the architecture of the neural circuit, based on the well characterized synaptic organization of the cerebellum and its relationship to a simple form of motor learning.
Journal ArticleDOI
Brain substrates of classical eyeblink conditioning: a highly localized but also distributed system.
TL;DR: Data presented suggest that classical eyeblink conditioning can also be characterized as a distributed system, and involvement of the cerebellum in associative learning and memory seems to be limited by certain parametric conditions present at the time of learning.
Book ChapterDOI
Attention Coordination and Anticipatory Control
TL;DR: The idea that the cerebellum is a master computational system that anticipates and adjusts responsiveness in a variety of brain systems to efficiently achieve goals determined by cerebral and other subcortical systems is discussed.
Journal ArticleDOI
Cerebellar learning in the vestibulo-ocular reflex.
TL;DR: This article reviews recent studies on the learning mechanisms of the cerebellum that underlie the adaptation of the vestibulo-ocular reflex and investigates the signal content in flocculus Purkinje cells.
References
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Journal ArticleDOI
Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.
Timothy V. P. Bliss,T. Lømo +1 more
TL;DR: The after‐effects of repetitive stimulation of the perforant path fibres to the dentate area of the hippocampal formation have been examined with extracellular micro‐electrodes in rabbits anaesthetized with urethane.
Journal ArticleDOI
A Theory of Cerebellar Cortex
TL;DR: A detailed theory of cerebellar cortex is proposed whose consequence is that the cerebellum learns to perform motor skills and two forms of input—output relation are described, both consistent with the cortical theory.
Journal ArticleDOI
A Theory of Cerebellar Function
TL;DR: It is demonstrated that, in order for the learning process to be stable, pattern storage must be accomplished principally by weakening synaptic weights rather than by strengthening them.
Journal ArticleDOI
Habituation: A model phenomenon for the study of neuronal substrates of behavior.
TL;DR: An apparatus for cleaning and sterilizing objects, such as pharmaceutical caps, plugs and the like, includes an autoclave chamber and a cleaning device having a cleaning drum mounted for a free rotation on a frame.
Journal ArticleDOI
Hippocampus, space, and memory
TL;DR: It is proposed that the hippocampus is selectively involved in behaviors that require working memory, irrespective of the type of material (spatial or nonspatial) that is to be processed by that memory.