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Tissue engineering : Frontiers in biotechnology

R. Langer, +1 more
- 01 Jan 1993 - 
- Vol. 260, Iss: 5110, pp 920-926
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This article is published in Science.The article was published on 1993-01-01 and is currently open access. It has received 5981 citations till now.

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An update on clinical regenerative endodontics

TL;DR: This review summarizes the evolution of Regenerative endodontic procedures while presenting recent advances, including treatment protocol modifications based on translational studies and future bioengineering approaches.
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Poly-epsilon-caprolactone/hydroxyapatite composites for bone regeneration: in vitro characterization and human osteoblast response.

TL;DR: PCL represents a potential candidate as an efficient substrate for bone substitution through an accurate balance between structural/ mechanical properties of polymer and biological activities and was found to improve osteoconduction compared to the PCL alone.
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Bone tissue engineering in a rotating bioreactor using a microcarrier matrix system.

TL;DR: Polymer microencapsulation methods are adapted for the formation of hollow, lighter-than-water microcarriers of degradable poly(lactic-co-glycolic acid) for in vitro mineralized bone tissue growth and preliminary cell culture studies show that osteoblast-like cells readily attached to microcarrier scaffolds.
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Electrospinning approaches toward scaffold engineering--a brief overview.

TL;DR: Electrospinning is the technique of choice for the preparation of scaffolds based on nanofibers mimicking to a certain extent the structure of the extracellular matrix that promote cell adhesion, proliferation, and differentiation in tissue engineering.
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Temperature-responsive intelligent interfaces for biomolecular separation and cell sheet engineering

TL;DR: Temperature-responsive intelligent surfaces prepared by the modification of an interface with poly(N-isopropylacrylamide) and its derivatives are focused on, which allow the recovery of confluent cell monolayers as contiguous living cell sheets for tissue-engineering applications.
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