Open AccessJournal Article
Tissue engineering : Frontiers in biotechnology
R. Langer,J. P. Vacanti +1 more
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This article is published in Science.The article was published on 1993-01-01 and is currently open access. It has received 5981 citations till now.read more
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Book ChapterDOI
Scaffolds for tissue engineering and 3D cell culture.
TL;DR: This chapter reviews the principal polymeric materials that are used for the fabrication of scaffolds and the scaffold fabrication processes, with examples of properties and selected applications.
Journal ArticleDOI
A new approach based on injection moulding to produce biodegradable starch-based polymeric scaffolds: morphology, mechanical and degradation behaviour.
TL;DR: It was demonstrated that it is possible to obtain, by a standard melt based processing route, 3D scaffolds with complex shapes that exhibit an appropriate morphology, without decreasing significantly the mechanical properties of the materials.
Journal ArticleDOI
Control of in vitro tissue-engineered bone-like structures using human mesenchymal stem cells and porous silk scaffolds.
Sandra Hofmann,Henri Hagenmüller,Annette Koch,Ralph Müller,Gordana Vunjak-Novakovic,Gordana Vunjak-Novakovic,David L. Kaplan,Hans P. Merkle,Lorenz Meinel,Lorenz Meinel +9 more
TL;DR: It is hypothesized that tissue engineered bone-like structure resulting from silk fibroin (SF) implants is pre-determined by the scaffolds' geometry, and dynamic cell seeding in spinner flasks resulted in equal cell viability and proliferation, and better cell distribution throughout the scaffold as visualized by histology and confocal microscopy.
Journal ArticleDOI
Fabrication of functional three-dimensional tissues by stacking cell sheets in vitro
Yuji Haraguchi,Tatsuya Shimizu,Tadashi Sasagawa,Hidekazu Sekine,Katsuhisa Sakaguchi,Tetsutaro Kikuchi,Waki Sekine,Sachiko Sekiya,Masayuki Yamato,Mitsuo Umezu,Teruo Okano +10 more
TL;DR: The laboratory has developed a fabrication system for functional 3D tissues by stacking cell sheets of confluent cultured cells detached from a temperature-responsive culture dish and it is possible to fabricate other tissues, such as 3D tissue from endothelial cells sandwiched between layered cell sheets.
Journal ArticleDOI
Tethered epidermal growth factor as a paradigm for growth factor–induced stimulation from the solid phase
TL;DR: Tethered epidermal growth factor was as effective as soluble EGF in eliciting DNA synthesis and cell rounding responses of primary rat hepatocytes under different surface conditions and physically adsorbed EGF at comparable surface concentrations showed no activity.