Open AccessJournal Article
Tissue engineering : Frontiers in biotechnology
R. Langer,J. P. Vacanti +1 more
About:
This article is published in Science.The article was published on 1993-01-01 and is currently open access. It has received 5981 citations till now.read more
Citations
More filters
Journal ArticleDOI
Properties and medical applications of polylactic acid: A review
TL;DR: In this article, the authors described the principles of the polymerization reactions of PLA and outlined the various materials properties affect- ing the performance of PLA polymer, such as rheological, mechanical, thermal, and barrier properties as well as the pro- cessing technologies which were used to fabricate products based on PLA.
Journal ArticleDOI
Creation Of Viable Pulmonary Artery Autografts Through Tissue Engineering
Toshiharu Shinoka,Dominique Shum-Tim,Peter X. Ma,Ronn E. Tanel,Noritaka Isogai,Robert Langer,Joseph P. Vacanti,John E. Mayer +7 more
TL;DR: Living vascular grafts engineered from autologous cells and biodegradable polymers functioned well in the pulmonary circulation as a pulmonary artery replacement and demonstrated an increase in diameter suggesting growth and development of endothelial lining and extracellular matrix, including collagen and elastic fibers.
Journal ArticleDOI
The effect of incorporating RGD adhesive peptide in polyethylene glycol diacrylate hydrogel on osteogenesis of bone marrow stromal cells.
Fan Yang,Christopher G. Williams,Dong-An Wang,Hyukjin Lee,Paul N. Manson,Jennifer H. Elisseeff +5 more
TL;DR: It is demonstrated that RGD-conjugated PEODA hydrogel promotes the osteogenesis of MSCs in a dosage-dependent manner, with 2.5 mm being optimal concentration.
Journal ArticleDOI
Silk implants for the healing of critical size bone defects
Lorenz Meinel,Robert Fajardo,Sandra Hofmann,Sandra Hofmann,Robert Langer,Jake Y. Chen,Brian D. Snyder,Gordana Vunjak-Novakovic,David L. Kaplan +8 more
TL;DR: The feasibility of silk-based implants with engineered bone for the (re-)generation of bone tissues is demonstrated and the class of protein-based bone-implant materials with a mechanically stable and durable option is expanded.
Journal ArticleDOI
Hierarchically biomimetic bone scaffold materials: Nano-HA/collagen/PLA composite†
TL;DR: This scaffold composite has promise for the clinical repair of large bony defects according to the principles of bone tissue engineering and cell culture and animal model tests showed that the composite material is bioactive.