Open AccessJournal Article
Tissue engineering : Frontiers in biotechnology
R. Langer,J. P. Vacanti +1 more
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This article is published in Science.The article was published on 1993-01-01 and is currently open access. It has received 5981 citations till now.read more
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Force Required to Break α5β1Integrin-Fibronectin Bonds in Intact Adherent Cells Is Sensitive to Integrin Activation State
TL;DR: A model system is developed that characterizes the functional binding characteristic for adhesion receptors as the force required to separate the integrin-ligand bond and provides a basis for analysis of the functions of signaling and cytoskeletal elements in the adhesion process.
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Nanofiber-based delivery of bioactive agents and stem cells to bone sites
TL;DR: The basic concepts and recent advances of self-assembly, electrospinning and thermally induced phase separation techniques that are widely used to generate nanofibrous scaffolds are reviewed and surface functionalization and bioactive factor delivery within these nanofiber-based scaffolds to enhance bone regeneration are discussed.
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Fabrication and evaluation of nanoporous alumina membranes for osteoblast culture
TL;DR: This research combined the advantages of using alumina, a material with proven biocompatibility and current orthopedic clinical applications, and incorporated porous features on the nanoscale which have been reported to improve osteoblast response.
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Acidic Microclimate pH Distribution in PLGA Microspheres Monitored by Confocal Laser Scanning Microscopy
TL;DR: Coupling this ratiometric method with that previously developed (SNARF-1® dextran for µpH 5.8–8.0) should provide microclimate pH mapping over the entire useful pH range for optimization of PLGA delivery of pH-sensitive bioactive substances.
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Hydrogels in Spinal Cord Injury Repair Strategies
Giuseppe Perale,Filippo Rossi,Erik Sundström,Sara Bacchiega,Maurizio Masi,Gianluigi Forloni,Pietro Veglianese +6 more
TL;DR: Different hydrogel applications are underlined, together with their different nature, in order to have a clearer view of what is happening in one of the most sparkling fields of regenerative medicine.