Open AccessJournal Article
Tissue engineering : Frontiers in biotechnology
R. Langer,J. P. Vacanti +1 more
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This article is published in Science.The article was published on 1993-01-01 and is currently open access. It has received 5981 citations till now.read more
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Nanotechnological strategies for engineering complex tissues.
TL;DR: The nanocomposite nature of the extracellular matrix is reviewed, the design considerations for different tissues are described, and the impact of nanostructures on the properties of scaffolds and their uses in monitoring the behaviour of engineered tissues are discussed.
Journal ArticleDOI
Scaffolding in tissue engineering: general approaches and tissue-specific considerations.
Barbara P. Chan,K. W. Leong +1 more
TL;DR: The functions of scaffolds and the major scaffolding approaches as important guidelines for selecting scaffolds are reviewed and the tissue-specific considerations for scaffolding are discussed, using intervertebral disc as an example.
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Making tissue engineering scaffolds work. Review: the application of solid freeform fabrication technology to the production of tissue engineering scaffolds.
TL;DR: Solid freeform fabrication (SFF) uses layer-manufacturing strategies to create physical objects directly from computer-generated models to enable the cells to behave in the required manner to produce tissues and organs of the desired shape and size.
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Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix
Basak E. Uygun,Alejandro Soto-Gutierrez,Alejandro Soto-Gutierrez,Hiroshi Yagi,Hiroshi Yagi,Maria Louisa Izamis,Maria Angela Guzzardi,Maria Angela Guzzardi,Carley Shulman,Jack M. Milwid,Naoya Kobayashi,Arno W. Tilles,Francois Berthiaume,Francois Berthiaume,Martin Hertl,Yaakov Nahmias,Yaakov Nahmias,Martin L. Yarmush,Martin L. Yarmush,Korkut Uygun +19 more
TL;DR: A novel approach to generate transplantable liver grafts using decellularized liver matrix that preserves the structural and functional characteristics of the native microvascular network, allowing efficient recellularization of the liver matrix with adult hepatocytes and subsequent perfusion for in vitro culture.
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Biodegradable Polymer Scaffolds for Tissue Engineering
Lisa E. Freed,Gordana Vunjak-Novakovic,Robert J. Biron,Dana Burton Eagles,Daniel C. Lesnoy,Sandra K. Barlow,Robert Langer +6 more
TL;DR: The scaffold induced chondrocyte differentiation with respect to morphology and phenotype and represents a model cell culture substrate that may be useful for a variety of tissue engineering applications.