Journal ArticleDOI
Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome
Jérôme Galon,Anne Costes,Fátima Sánchez-Cabo,Amos Kirilovsky,Bernhard Mlecnik,Christine Lagorce-Pagès,Marie Tosolini,Matthieu Camus,Anne Berger,Philippe Wind,Franck Zinzindohoué,Patrick Bruneval,Paul-Henri Cugnenc,Zlatko Trajanoski,Wolf H. Fridman,Franck Pagès +15 more
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TLDR
In situ analysis of tumor-infiltrating immune cells may be a valuable prognostic tool in the treatment of colorectal cancer and possibly other malignancies.Abstract:
The role of the adaptive immune response in controlling the growth and recurrence of human tumors has been controversial. We characterized the tumor-infiltrating immune cells in large cohorts of human colorectal cancers by gene expression profiling and in situ immunohistochemical staining. Collectively, the immunological data (the type, density, and location of immune cells within the tumor samples) were found to be a better predictor of patient survival than the histopathological methods currently used to stage colorectal cancer. The results were validated in two additional patient populations. These data support the hypothesis that the adaptive immune response influences the behavior of human tumors. In situ analysis of tumor-infiltrating immune cells may therefore be a valuable prognostic tool in the treatment of colorectal cancer and possibly other malignancies.read more
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Journal IssueDOI
Immune checkpoint inhibitors in cancer therapy
Eika Webb,Peng Liu,Renato B. Baleeiro,Nicholas R. Lemoine,Nicholas R. Lemoine,Ming Yuan,Yaohe Wang,Yaohe Wang +7 more
TL;DR: The focus shifted from developing therapies that targeted activation of the host immune system against cancer to checkpoint inhibitors, which aimed to mediate tumor cell destruction through the removal of coinhibitory signals blocking anti-tumor T cell responses.
Journal ArticleDOI
Analysis of the T-Cell Receptor Repertoires of Tumor-Infiltrating Conventional and Regulatory T Cells Reveals No Evidence for Conversion in Carcinogen-Induced Tumors
James P. Hindley,Cristina Ferreira,Emma Jones,Sarah Nicol Lauder,Kristin Ladell,Katherine K Wynn,Gareth James Betts,Yogesh Singh,David Price,Andrew James Godkin,Julian Dyson,Awen Gallimore +11 more
TL;DR: Analysis of the TCR repertoires of Tregs and Tconvs within tumor-infiltrating lymphocytes (TIL) are shown to be largely distinct, and enrichment of TRegs within TILs most likely reflects differences in the way that T Regs andTconvs are influenced by the tumor microenvironment.
Journal ArticleDOI
Racial Differences in Cancer Susceptibility and Survival: More Than the Color of the Skin?
TL;DR: The molecular basis of racial disparity in cancer susceptibility ranging from genetic polymorphisms and cancer-driver gene mutations to obesity, chronic inflammation, and immune responses is overviewed.
Book ChapterDOI
Deconvoluting tumor-infiltrating immune cells from RNA-seq data using quanTIseq.
TL;DR: This chapter analyzes raw RNA-seq data from bulk tumor samples of melanoma patients collected before and on-treatment with kinase inhibitors to show how quanTIseq can be used to reveal the immunological effects of targeted and conventional drugs.
Journal ArticleDOI
The Immune System — is it Relevant to Cancer Development, Progression and Treatment?
Robin Prestwich,Robin Prestwich,Fiona Errington,P. Hatfield,Alison Merrick,Elizabeth Ilett,Peter Selby,Alan Melcher,Alan Melcher +8 more
TL;DR: 'Immunoediting' is an updated hypothesis, in which selection pressures applied by the immune response to tumours modulate tumour immunogenicity and growth, and will guide the future combination of immunotherapy with conventional therapy to achieve optimal anti-tumour effects.
References
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Journal ArticleDOI
Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
Journal ArticleDOI
Cancer immunoediting: from immunosurveillance to tumor escape.
TL;DR: The historical and experimental basis of cancer immunoediting is summarized and its dual roles in promoting host protection against cancer and facilitating tumor escape from immune destruction are discussed.
Journal ArticleDOI
A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma
P. van der Bruggen,Catia Traversari,Patrick Chomez,Christophe Lurquin,E De Plaen,B Van den Eynde,Alexander Knuth,Thierry Boon +7 more
TL;DR: In this paper, a gene was identified that directed the expression of antigen MZ2-E on a human melanoma cell line, which belongs to a family of at least three genes.
Journal ArticleDOI
Tumour-educated macrophages promote tumour progression and metastasis
TL;DR: Macrophages are educated by the tumour microenvironment, so that they adopt a trophic role that facilitates angiogenesis, matrix breakdown and tumour-cell motility — all of which are elements of the metastatic process.
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