Journal ArticleDOI
Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome
Jérôme Galon,Anne Costes,Fátima Sánchez-Cabo,Amos Kirilovsky,Bernhard Mlecnik,Christine Lagorce-Pagès,Marie Tosolini,Matthieu Camus,Anne Berger,Philippe Wind,Franck Zinzindohoué,Patrick Bruneval,Paul-Henri Cugnenc,Zlatko Trajanoski,Wolf H. Fridman,Franck Pagès +15 more
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TLDR
In situ analysis of tumor-infiltrating immune cells may be a valuable prognostic tool in the treatment of colorectal cancer and possibly other malignancies.Abstract:
The role of the adaptive immune response in controlling the growth and recurrence of human tumors has been controversial. We characterized the tumor-infiltrating immune cells in large cohorts of human colorectal cancers by gene expression profiling and in situ immunohistochemical staining. Collectively, the immunological data (the type, density, and location of immune cells within the tumor samples) were found to be a better predictor of patient survival than the histopathological methods currently used to stage colorectal cancer. The results were validated in two additional patient populations. These data support the hypothesis that the adaptive immune response influences the behavior of human tumors. In situ analysis of tumor-infiltrating immune cells may therefore be a valuable prognostic tool in the treatment of colorectal cancer and possibly other malignancies.read more
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The interplay between HPV and host immunity in head and neck squamous cell carcinoma
TL;DR: The HPV‐specific immune response is suggested to play a role in the significantly better response to therapy of HPV‐positive patients, and immunotherapy trials targeting HPV are underway, providing hope for decreasing treatment‐related toxicity.
Journal ArticleDOI
Cancer: Macrophages limit chemotherapy
Michele De Palma,Claire E. Lewis +1 more
TL;DR: White blood cells called macrophages often infiltrate tumours in large numbers, and now appear to promote tumour chemoresistance, a major hurdle to successful cancer treatment.
Journal ArticleDOI
Sensors of ionizing radiation effects on the immunological microenvironment of cancer.
TL;DR: It is proposed that specific radiation-induced effects could be successfully exploited to improve the effectiveness of immunotherapy, and elucidates which pathways are specifically altered in cancer.
Journal ArticleDOI
Effects of infiltrating lymphocytes and estrogen receptor on gene expression and prognosis in breast cancer
Alberto Calabrò,Tim Beissbarth,Ruprecht Kuner,Michael Stojanov,Axel Benner,Martin Asslaber,Ferdinand Ploner,Kurt Zatloukal,Hellmut Samonigg,Annemarie Poustka,Holger Sültmann +10 more
TL;DR: Evaluating the prognostic value of LI in breast cancer samples using microarray-based screening for LI-associated genes showed that LI alone is not sufficient to highlight breast cancer patients with different prognosis, but for ER positive patients, high LI was associated with shorter survival times, whereas for ER negative patients,High LI is significantly associated with longer survival.
Journal ArticleDOI
Experimental mouse tumour models: what can be learnt about human cancer immunology?
TL;DR: Experimental mouse tumour models have provided key mechanistic insights into host antitumour immune responses, and these have guided the development of novel treatment strategies, but investigators need to gain a better understanding of their strengths and limitations.
References
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Journal ArticleDOI
Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
Journal ArticleDOI
Cancer immunoediting: from immunosurveillance to tumor escape.
TL;DR: The historical and experimental basis of cancer immunoediting is summarized and its dual roles in promoting host protection against cancer and facilitating tumor escape from immune destruction are discussed.
Journal ArticleDOI
A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma
P. van der Bruggen,Catia Traversari,Patrick Chomez,Christophe Lurquin,E De Plaen,B Van den Eynde,Alexander Knuth,Thierry Boon +7 more
TL;DR: In this paper, a gene was identified that directed the expression of antigen MZ2-E on a human melanoma cell line, which belongs to a family of at least three genes.
Journal ArticleDOI
Tumour-educated macrophages promote tumour progression and metastasis
TL;DR: Macrophages are educated by the tumour microenvironment, so that they adopt a trophic role that facilitates angiogenesis, matrix breakdown and tumour-cell motility — all of which are elements of the metastatic process.
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