抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Probability Distributions.- Linear Models for Regression.- Linear Models for Classification.- Neural Networks.- Kernel Methods.- Sparse Kernel Machines.- Graphical Models.- Mixture Models and EM.- Approximate Inference.- Sampling Methods.- Continuous Latent Variables.- Sequential Data.- Combining Models.

Pattern Recognition and Machine Learning

The 11th edition of Harrison's Principles of Internal Medicine welcomes Anthony Fauci to its editorial staff, in addition to more than 85 new contributors. While the organization of the book is similar to previous editions, major emphasis has been placed on disorders that affect multiple organ systems. Important advances in genetics, immunology, and oncology are emphasized. Many chapters of the book have been rewritten and describe major advances in internal medicine. Subjects that received only a paragraph or two of attention in previous editions are now covered in entire chapters. Among the chapters that have been extensively revised are the chapters on infections in the compromised host, on skin rashes in infections, on many of the viral infections, including cytomegalovirus and Epstein-Barr virus, on sexually transmitted diseases, on diabetes mellitus, on disorders of bone and mineral metabolism, and on lymphadenopathy and splenomegaly. The major revisions in these chapters and many

Harrison's Principles of Internal Medicine

Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction

Nanocrystals are fundamental to modern science and technology. Mastery over the shape of a nanocrystal enables control of its properties and enhancement of its usefulness for a given application. Our aim is to present a comprehensive review of current research activities that center on the shape-controlled synthesis of metal nanocrystals. We begin with a brief introduction to nucleation and growth within the context of metal nanocrystal synthesis, followed by a discussion of the possible shapes that a metal nanocrystal might take under different conditions. We then focus on a variety of experimental parameters that have been explored to manipulate the nucleation and growth of metal nanocrystals in solution-phase syntheses in an effort to generate specific shapes. We then elaborate on these approaches by selecting examples in which there is already reasonable understanding for the observed shape control or at least the protocols have proven to be reproducible and controllable. Finally, we highlight a number of applications that have been enabled and/or enhanced by the shape-controlled synthesis of metal nanocrystals. We conclude this article with personal perspectives on the directions toward which future research in this field might take.

Shape‐Controlled Synthesis of Metal Nanocrystals: Simple Chemistry Meets Complex Physics?

Cogeneration is the simultaneous generation of two different forms of energy from a single source. Normally, when thermal as well as electrical energies are required in process industries like chemical, paper, steel, etc., cogeneration systems are preferred. Generating these energies independently is energy inefficient process. However, depending on the requirement of heat and electrical loads, industries have adopted different conventional designs based on process requirements. This paper proposed improvements to the existing conventional cogeneration designs by integrating them with renewable energy sources including suitable energy storage devices, thereby increasing the efficiency of cogeneration plants and resulting in drastic fossil fuels savings and helping in sustainable energy and environmental security.

Cogeneration Plants Design Optimization by Integrating Them with Renewable Energy Towards Sustainable Energy and Environmental Security

Comparative study of effect of stress on peak expiratory flow rate and body mass index in medical and non-medical students

Guest Editorial: Advanced information hiding techniques for industrial applications

This chapter analyses real world human activity recognition problem. It uses discrete wavelet transform and multiclass support vector machine (SVM) classifier for recognition. The experiments are done using Weizmann and KTH action datasets. Objective evaluation is done for nine activities walk, run, bend, gallop sideways, jumping jack, one handwave, two handwave, jump in place and skip from Weizmann dataset. Six activities that are considered from KTH dataset are handwaving, running, walking, boxing, jogging and handclapping. Results are shown qualitatively as well as quantitatively on two publicly available dataset Weizmann and KTH. Quantitative evaluations demonstrate better performance of the proposed method in comparison to the existing methods.

Wavelets for Activity Recognition

N, et al. Targeted nextgeneration sequencing in blast phase myeloproliferative neoplasms. Blood Adv. 2018;2:370–80. 7. McNamara CJ, Panzarella T, Kennedy JA, Arruda A, Claudio JO, DaherReyes G, et al. The mutational landscape of acceleratedand blast-phase myeloproliferative neoplasms impacts patient outcomes. Blood Adv. 2018;2:2658–71. 8. D€ ohner H, Estey E, Grimwade D, Amadori S, Appelbaum FR, B€ uchner T, et al. Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel. Blood. 2017;129:424–47. 9. Mascarenhas J, Heaney ML, Najfeld V, Hexner E, Abdel-Wahab O, Rampal R, et al. Proposed criteria for response assessment in patients treated in clinical trials for myeloproliferative neoplasms in blast phase (MPNBP): formal recommendations from the post-myeloproliferative neoplasm acute myeloid leukemia consortium. Leuk Res. 2012;36:1500–4. 10. McKenney AS, Lau AN, Somasundara AVH, Spitzer B, Intlekofer AM, Ahn J, et al. JAK2/IDH-mutant-driven myeloproliferative neoplasm is sensitive to combined targeted inhibition. J Clin Investig. 2018;128:789–804.

Amit Singh

Papers

Cogeneration Plants Design Optimization by Integrating Them with Renewable Energy Towards Sustainable Energy and Environmental Security

Comparative study of effect of stress on peak expiratory flow rate and body mass index in medical and non-medical students

Guest Editorial: Advanced information hiding techniques for industrial applications

Wavelets for Activity Recognition

Delayed resistance to imatinib after 16 years of therapy in a patient with chronic myeloid leukaemia.