Showing papers by "Atsushi Takahashi published in 2020"
University of North Carolina at Chapel Hill1, University of Massachusetts Amherst2, University of Oxford3, The Chinese University of Hong Kong4, Kyoto University5, Seoul National University Hospital6, Vanderbilt University Medical Center7, National University of Singapore8, Academia Sinica9, Nagoya University10, Los Angeles Biomedical Research Institute11, University of California, Los Angeles12, Hallym University13, University of Texas Health Science Center at Houston14, University of Michigan15, Wake Forest University16, Genentech17, London North West Healthcare NHS Trust18, Imperial College London19, University of Liverpool20, University of Manchester21, Kyushu University22, Peking Union Medical College23, National Taiwan University24, University of Minnesota25, Chinese National Human Genome Center26, National Defense Medical Center27, Tri-Service General Hospital28, Taipei Veterans General Hospital29, National Yang-Ming University30, Jichi Medical University31, Heidelberg University32, University of Tokyo33, Osaka University34, Agency for Science, Technology and Research35, University of the Ryukyus36, Ehime University37, Samsung Medical Center38, Yonsei University39, University of San Carlos40, Peking University41, Macau University of Science and Technology42, China Medical University (Taiwan)43, Shanghai Jiao Tong University44, Kurume University45, University of Pittsburgh46, Capital Medical University47, New Generation University College48, Seoul National University49
TL;DR: A meta-analysis of genome-wide association study data from 77,418 individuals of East Asian ancestry with type 2 diabetes identifies novel variants associated with increased risk of type 2abetes in both East Asian and European populations.
Abstract: Meta-analyses of genome-wide association studies (GWAS) have identified more than 240 loci that are associated with type 2 diabetes (T2D)1,2; however, most of these loci have been identified in analyses of individuals with European ancestry. Here, to examine T2D risk in East Asian individuals, we carried out a meta-analysis of GWAS data from 77,418 individuals with T2D and 356,122 healthy control individuals. In the main analysis, we identified 301 distinct association signals at 183 loci, and across T2D association models with and without consideration of body mass index and sex, we identified 61 loci that are newly implicated in predisposition to T2D. Common variants associated with T2D in both East Asian and European populations exhibited strongly correlated effect sizes. Previously undescribed associations include signals in or near GDAP1, PTF1A, SIX3, ALDH2, a microRNA cluster, and genes that affect the differentiation of muscle and adipose cells3. At another locus, expression quantitative trait loci at two overlapping T2D signals affect two genes-NKX6-3 and ANK1-in different tissues4-6. Association studies in diverse populations identify additional loci and elucidate disease-associated genes, biology, and pathways.
218 citations
Vanderbilt University Medical Center1, Chonnam National University2, New Generation University College3, University of Cambridge4, Vanderbilt University5, Queen's University6, Li Ka Shing Faculty of Medicine, University of Hong Kong7, Shanghai Jiao Tong University8, National University of Singapore9, University of Nottingham Malaysia Campus10, Nagoya University11, Stanford University12, Cancer Prevention Institute of California13, University of Hong Kong14, Karolinska Institutet15, Genome Institute of Singapore16, University of Warwick17, University of Manchester18, University of Tokyo19, Seoul National University Hospital20, Hanyang University21, China Medical University (Taiwan)22, University of British Columbia23, University of Southern California24, Centers for Disease Control and Prevention25, University of Melbourne26, Cancer Council Victoria27, Monash University, Clayton campus28, University of Malaya29, Laval University30
TL;DR: A meta-analysis of GWAS data from Asian populations finds 31 potential new risk loci, 10 of which are validated in an independent disease cohort and improve the understanding of breast cancer genetics and etiology.
Abstract: Known risk variants explain only a small proportion of breast cancer heritability, particularly in Asian women. To search for additional genetic susceptibility loci for breast cancer, here we perform a meta-analysis of data from genome-wide association studies (GWAS) conducted in Asians (24,206 cases and 24,775 controls) and European descendants (122,977 cases and 105,974 controls). We identified 31 potential novel loci with the lead variant showing an association with breast cancer risk at P < 5 × 10-8. The associations for 10 of these loci were replicated in an independent sample of 16,787 cases and 16,680 controls of Asian women (P < 0.05). In addition, we replicated the associations for 78 of the 166 known risk variants at P < 0.05 in Asians. These findings improve our understanding of breast cancer genetics and etiology and extend previous findings from studies of European descendants to Asian women.
36 citations
01 Jun 2020
TL;DR: Three new loci on chromosome 1q21 (CTSS), 10q26 (WDR11-FGFR2), and 11q22 (RDX-FDX1) are identified and highlighted the genetic differences between the Japanese and European populations of coronary artery disease.
Abstract: Background: Genome-wide association studies provided many biological insights into coronary artery disease (CAD), but these studies were mainly performed in Europeans. Genome-wide association studi...
28 citations
TL;DR: In this article, a temperature-programed desorption analysis of the reactivity of H2O with Au nanoparticles was carried out at low temperatures (<320 K) to clarify the role of H 2O in the oxidation of CO over Au/TiO2.
Abstract: To clarify the role of H2O in the oxidation of CO over Au/TiO2 at low temperatures (<320 K), we conducted a temperature-programed desorption analysis of the reactivity of H2O with Au nanoparticles ...
25 citations
DOI•
Vanderbilt University Medical Center1, Chonnam National University2, New Generation University College3, University of Cambridge4, Vanderbilt University5, Queen's University6, Li Ka Shing Faculty of Medicine, University of Hong Kong7, Shanghai Jiao Tong University8, National University of Singapore9, University of Nottingham Malaysia Campus10, Nagoya University11, Cancer Prevention Institute of California12, Stanford University13, University of Hong Kong14, Genome Institute of Singapore15, Karolinska Institutet16, University of Manchester17, University of Warwick18, University of Tokyo19, Seoul National University Hospital20, Hanyang University21, China Medical University (Taiwan)22, University of British Columbia23, University of Southern California24, Centers for Disease Control and Prevention25, Monash University, Clayton campus26, University of Melbourne27, Cancer Council Victoria28, University of Malaya29, Laval University30
TL;DR: This paper performed a meta-analysis of data from genome-wide association studies (GWAS) conducted in Asians (24,206 cases and 24,775 controls) and European descendants (122,977 cases and 105,974 controls).
Abstract: Known risk variants explain only a small proportion of breast cancer heritability, particularly in Asian women. To search for additional genetic susceptibility loci for breast cancer, here we perform a meta-analysis of data from genome-wide association studies (GWAS) conducted in Asians (24,206 cases and 24,775 controls) and European descendants (122,977 cases and 105,974 controls). We identified 31 potential novel loci with the lead variant showing an association with breast cancer risk at P < 5 × 10-8. The associations for 10 of these loci were replicated in an independent sample of 16,787 cases and 16,680 controls of Asian women (P < 0.05). In addition, we replicated the associations for 78 of the 166 known risk variants at P < 0.05 in Asians. These findings improve our understanding of breast cancer genetics and etiology and extend previous findings from studies of European descendants to Asian women.
15 citations
TL;DR: In this paper, highly active Ru/MgO catalysts were successfully prepared by using Ru hydroxide and hydromagnetic acid (HOOHA) catalysts, respectively.
Abstract: Ammonia decomposition on Ru/MgO was strongly affected by the pore structure of the MgO support. We found that highly active Ru/MgO catalysts were successfully prepared by using Ru hydroxide and hyd...
14 citations
TL;DR: This research presents a novel probabilistic procedure called “spot-spot analysis” that allows for real-time analysis of the response of the immune system to foreign substance abuse.
4 citations
TL;DR: In this paper, the concerted effect of NaOH and O2 in different reaction steps was investigated for the highly selective production of glyceric acid, and it was clarified that NaOH was involved in the activation step to a glycerol alkoxide intermediate (2, 3−dihydroxypropoxide) in the liquid phase, then glycerric acid was formed by OOH species derived from O2 on an Au catalyst in the partial oxidation step.
Abstract: Glycerol can be effectively converted to glyceric acid, a high value‐added pharmaceutical raw material, through its partial oxidation over an Au/Al2O3 catalyst under strongly basic conditions. The factors important for the highly selective production of glyceric acid were investigated experimentally. It was clarified that NaOH was involved in the glycerol activation step to a glycerol alkoxide intermediate (2, 3‐dihydroxypropoxide) in the liquid phase, then glyceric acid was formed by OOH species derived from O2 on an Au catalyst in the partial oxidation step. We have newly discovered the concerted effect of NaOH and O2 in different reaction steps.
2 citations