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Iona Y Millwood
Researcher at University of Oxford
Publications - 73
Citations - 3123
Iona Y Millwood is an academic researcher from University of Oxford. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 22, co-authored 73 publications receiving 1471 citations. Previous affiliations of Iona Y Millwood include Medical Research Council & Clinical Trial Service Unit.
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Journal ArticleDOI
Conventional and genetic evidence on alcohol and vascular disease aetiology: a prospective study of 500 000 men and women in China
Iona Y Millwood,Iona Y Millwood,Robin G. Walters,Robin G. Walters,Xue W Mei,Xue W Mei,Yu Guo,Ling Yang,Ling Yang,Zheng Bian,Derrick A Bennett,Yiping Chen,Yiping Chen,Caixia Dong,Ruying Hu,Gang Zhou,Bo Yu,Weifang Jia,Sarah Parish,Sarah Parish,Robert Clarke,George Davey Smith,Rory Collins,Michael V. Holmes,Michael V. Holmes,Liming Li,Richard Peto,Zhengming Chen +27 more
TL;DR: Genetic epidemiology shows that the apparently protective effects of moderate alcohol intake against stroke are largely non-causal, and appears in this one study to have little net effect on the risk of myocardial infarction.
Journal ArticleDOI
Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets
Louise V. Wain,Louise V. Wain,Nick Shrine,María Soler Artigas,A. Mesut Erzurumluoglu,Boris Noyvert,Lara Bossini-Castillo,Ma'en Obeidat,Amanda P. Henry,Michael A. Portelli,Robert J. Hall,Charlotte K. Billington,Tracy L. Rimington,Anthony G. Fenech,Catherine John,Tineka Blake,Victoria E. Jackson,Richard J. Allen,Bram P. Prins,Archie Campbell,David J. Porteous,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Matthias Wielscher,Alan James,Alan James,Jennie Hui,Jennie Hui,Nicholas J. Wareham,Jing Hua Zhao,James F. Wilson,Peter K. Joshi,Beate Stubbe,Rajesh Rawal,Holger Schulz,Medea Imboden,Nicole Probst-Hensch,Stefan Karrasch,Christian Gieger,Ian J. Deary,Sarah E. Harris,Jonathan Marten,Igor Rudan,Stefan Enroth,Ulf Gyllensten,Shona M. Kerr,Ozren Polasek,Ozren Polasek,Mika Kähönen,Ida Surakka,Veronique Vitart,Caroline Hayward,Terho Lehtimäki,Olli T. Raitakari,David M. Evans,David M. Evans,A. John Henderson,Craig E. Pennell,Carol A. Wang,Peter D. Sly,Emily S. Wan,Robert Busch,Brian D. Hobbs,Augusto A. Litonjua,David Sparrow,Amund Gulsvik,Per Bakke,James D. Crapo,Terri H. Beaty,Nadia N. Hansel,Rasika A. Mathias,Ingo Ruczinski,Kathleen C. Barnes,Yohan Bossé,Philippe Joubert,Maarten van den Berge,Corry-Anke Brandsma,Peter D. Paré,Don D. Sin,David C. Nickle,Ke Hao,Omri Gottesman,Frederick E. Dewey,Shannon Bruse,David J. Carey,H. Lester Kirchner,Stefan Jonsson,Gudmar Thorleifsson,Ingileif Jonsdottir,Ingileif Jonsdottir,Thorarinn Gislason,Kari Stefansson,Kari Stefansson,Claudia Schurmann,Girish N. Nadkarni,Erwin P. Bottinger,Ruth J. F. Loos,Robin G. Walters,Zhengming Chen,Iona Y Millwood,Julien Vaucher,Om P Kurmi,Liming Li,Liming Li,Anna Hansell,Christopher E. Brightling,Christopher E. Brightling,Eleftheria Zeggini,Michael H. Cho,Edwin K. Silverman,Ian Sayers,Gosia Trynka,Andrew P. Morris,David P. Strachan,Ian P. Hall,Martin D. Tobin,Martin D. Tobin +116 more
TL;DR: In this article, a genetic risk score was associated with COPD susceptibility (odds ratio per 1 s.d. of the risk score (∼6 alleles) (95% confidence interval) = 1.24 (1.20-1.27), P = 5.05 × 10(-49)), and they observed a 3.7-fold difference in COPD risk between individuals in the highest and lowest GA risk score deciles in UK Biobank.
Journal ArticleDOI
Identification of type 2 diabetes loci in 433,540 East Asian individuals
Cassandra N. Spracklen,Cassandra N. Spracklen,Momoko Horikoshi,Young Jin Kim,Kuang Lin,Fiona Bragg,Sanghoon Moon,Ken Suzuki,Claudia H. T. Tam,Yasuharu Tabara,Soo Heon Kwak,Fumihiko Takeuchi,Jirong Long,Victor Jun Yu Lim,Jin-Fang Chai,Chien-Hsiun Chen,Masahiro Nakatochi,Jie Yao,Jie Yao,Hyeok Sun Choi,Apoorva K Iyengar,Hannah J Perrin,Sarah M Brotman,Martijn van de Bunt,Anna L. Gloyn,Jennifer E. Below,Jennifer E. Below,Michael Boehnke,Donald W. Bowden,John C. Chambers,Anubha Mahajan,Anubha Mahajan,Mark I. McCarthy,Maggie C.Y. Ng,Maggie C.Y. Ng,Lauren E. Petty,Lauren E. Petty,Weihua Zhang,Weihua Zhang,Andrew P. Morris,Andrew P. Morris,Andrew P. Morris,Linda S. Adair,Masato Akiyama,Zheng Bian,Juliana C.N. Chan,Li-Ching Chang,Miao-Li Chee,Yii-Der Ida Chen,Yii-Der Ida Chen,Yuan-Tsong Chen,Zhengming Chen,Lee-Ming Chuang,Shufa Du,Penny Gordon-Larsen,Myron D. Gross,Xiuqing Guo,Xiuqing Guo,Yu Guo,Sohee Han,Annie-Green Howard,Wei Huang,Yi-Jen Hung,Yi-Jen Hung,Mi Yeong Hwang,Chii-Min Hwu,Chii-Min Hwu,Sahoko Ichihara,Masato Isono,Hye-Mi Jang,Guozhi Jiang,Jost B. Jonas,Yoichiro Kamatani,Tomohiro Katsuya,Takahisa Kawaguchi,Chiea Chuen Khor,Chiea Chuen Khor,Katsuhiko Kohara,Myung-Shik Lee,Myung-Shik Lee,Nanette R. Lee,Liming Li,Jianjun Liu,Jianjun Liu,Andrea O.Y. Luk,Jun Lv,Yukinori Okada,Mark A Pereira,Charumathi Sabanayagam,Shi Jinxiu,Dong Mun Shin,Wing-Yee So,Atsushi Takahashi,Brian Tomlinson,Brian Tomlinson,Fuu Jen Tsai,Rob M. van Dam,Yong-Bing Xiang,Ken Yamamoto,Toshimasa Yamauchi,Kyungheon Yoon,Canqing Yu,Jian-Min Yuan,Liang Zhang,Wei Zheng,Michiya Igase,Yoon Shin Cho,Jerome I. Rotter,Jerome I. Rotter,Ya Xing Wang,Wayne Huey-Herng Sheu,Wayne Huey-Herng Sheu,Mitsuhiro Yokota,Jer-Yuarn Wu,Ching-Yu Cheng,Tien Yin Wong,Xiao-Ou Shu,Norihiro Kato,Kyong-Soo Park,Kyong-Soo Park,Kyong-Soo Park,E-Shyong Tai,Fumihiko Matsuda,Woon-Puay Koh,Ronald Cw Ma,Shiro Maeda,Iona Y Millwood,Ju Young Lee,Takashi Kadowaki,Robin G. Walters,Bong-Jo Kim,Karen L. Mohlke,Xueling Sim +132 more
TL;DR: A meta-analysis of genome-wide association study data from 77,418 individuals of East Asian ancestry with type 2 diabetes identifies novel variants associated with increased risk of type 2abetes in both East Asian and European populations.
Journal ArticleDOI
Causal associations of blood lipids with risk of ischemic stroke and intracerebral hemorrhage in Chinese adults
L Sun,Robert Clarke,Derrick A Bennett,Yu Guo,Robin G. Walters,Michael Hill,Sarah Parish,Iona Y Millwood,Zheng Bian,Yiping Chen,Canqing Yu,Jun Lv,Rory Collins,Junshi Chen,Richard Peto,Liming Li,Zhengming Chen +16 more
TL;DR: Wang et al. as discussed by the authors examined the associations of biochemically measured lipids with stroke in a nested case-control study in the China Kadoorie Biobank (CKB) and compared the risks for both stroke types associated with equivalent differences in LDL-C in Mendelian randomization analyses.
Posted ContentDOI
Identification of type 2 diabetes loci in 433,540 East Asian individuals
Cassandra N. Spracklen,Momoko Horikoshi,Young Jin Kim,Kuang Lin,Fiona Bragg,Sanghoon Moon,Ken Suzuki,Claudia H. T. Tam,Yasuharu Tabara,Soo Heon Kwak,Fumihiko Takeuchi,Jirong Long,Victor Jun Yu Lim,Jin-Fang Chai,Chien-Hsiun Chen,Masahiro Nakatochi,Jie Yao,Hyeok Sun Choi,Apoorva K Iyengar,Hannah J Perrin,Sarah M Brotman,Martijn van de Bunt,Anna L. Gloyn,Jennifer E. Below,Michael Boehnke,Donald W. Bowden,John C. Chambers,Anubha Mahajan,Mark I. McCarthy,Maggie C.Y. Ng,Lauren E. Petty,Weihua Zhang,Andrew P. Morris,Linda S. Adair,Zheng Bian,Juliana C.N. Chan,Li-Ching Chang,Miao-Li Chee,Yii-Der Ida Chen,Yuan-Tsong Chen,Zhengming Chen,Lee-Ming Chuang,Shufa Du,Penny Gordon-Larsen,Myron D. Gross,Xiuqing Guo,Yu Guo,Sohee Han,Annie-Green Howard,Wei Huang,Yi-Jen Hung,Mi Yeong Hwang,Chii-Min Hwu,Sahoko Ichihara,Masato Isono,Hye-Mi Jang,Guozhi Jiang,Jost B. Jonas,Yoichiro Kamatani,Tomohiro Katsuya,Takahisa Kawaguchi,Chiea Chuen Khor,Katsuhiko Kohara,Myung-Shik Lee,Nanette R. Lee,Liming Li,Jianjun Liu,Andrea O.Y. Luk,Jun Lv,Yukinori Okada,Mark A Pereira,Charumathi Sabanayagam,Shi Jinxiu,Dong Mun Shin,Wing-Yee So,Atsushi Takahashi,Brian Tomlinson,Fuu Jen Tsai,Rob M. van Dam,Yong-Bing Xiang,Ken Yamamoto,Toshimasa Yamauchi,Kyungheon Yoon,Canqing Yu,Jian-Min Yuan,Liang Zhang,Wei Zheng,Michiya Igase,Yoon Shin Cho,Jerome I. Rotter,Ya Xing Wang,Wayne Huey-Herng Sheu,Wayne Huey-Herng Sheu,Mitsuhiro Yokota,Jer-Yuarn Wu,Ching-Yu Cheng,Tien Yin Wong,Xiao-Ou Shu,Norihiro Kato,Kyong-Soo Park,E-Shyong Tai,Fumihiko Matsuda,Woon-Puay Koh,Ronald Cw Ma,Shiro Maeda,Iona Y Millwood,Ju Young Lee,Takashi Kadowaki,Robin G. Walters,Bong-Jo Kim,Karen L. Mohlke,Xueling Sim +111 more
TL;DR: The largest meta-analysis of East Asian individuals to identify new genetic associations and provide insight into T2D pathogenesis is performed.