Shona Allen

TL;DR: This study reveals a unified molecular genetic landscape of cortical cell types that congruently integrates their transcriptome, open chromatin and DNA methylation maps, and establishes a unified and mechanistic framework of neuronal cell type organization that integrates multi-layered molecular genetic and spatial information with multi-faceted phenotypic properties.

TL;DR: The findings support the use of CSF PrP as a pharmacodynamic biomarker for PrP-lowering drugs and suggest that relative reduction from individual baseline CSFPrP concentration may be an appropriate marker for target engagement.

TL;DR: In this article, the authors report the generation of a multimodal cell census and atlas of the mammalian primary motor cortex (MOp or M1) as the initial product of the BRAIN Initiative Cell Census Network (BICCN).

TL;DR: In this paper , the authors evaluated biomarker performance in plasma and identified the most reliable candidates for clinical trials for Alzheimer's Disease (AD) diagnosis. But, the day-to-day variability of these measures must be robustly characterized to determine which blood-based biomarkers would be the most sensitive for detecting treatment-related responses.