D
Deborah J. Thompson
Researcher at University of Cambridge
Publications - 148
Citations - 23537
Deborah J. Thompson is an academic researcher from University of Cambridge. The author has contributed to research in topics: Breast cancer & Genome-wide association study. The author has an hindex of 57, co-authored 143 publications receiving 20602 citations. Previous affiliations of Deborah J. Thompson include International Agency for Research on Cancer.
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Journal ArticleDOI
Genome-wide association study of endometrial cancer in E2C2
Immaculata De Vivo,Jennifer Prescott,Veronica Wendy Setiawan,Sara H. Olson,Nicolas Wentzensen,John Attia,John Attia,Amanda Black,Louise A. Brinton,Chu Chen,Constance Chen,Linda S. Cook,Linda S. Cook,Marta Crous-Bou,Jennifer A. Doherty,Alison M. Dunning,Douglas F. Easton,Christine M. Friedenreich,Montserrat Garcia-Closas,Mia M. Gaudet,Christopher A. Haiman,Susan E. Hankinson,Susan E. Hankinson,Patricia Hartge,Brian E. Henderson,Elizabeth G. Holliday,Elizabeth G. Holliday,Pamela L. Horn-Ross,David J. Hunter,Loic Le Marchand,Xiaolin Liang,Jolanta Lissowska,Jirong Long,Lingeng Lu,Anthony M. Magliocco,Mark McEvoy,Tracy A. O'Mara,Irene Orlow,Jodie N. Painter,Loreall Pooler,Radhai Rastogi,Timothy R. Rebbeck,Harvey A. Risch,Carlotta Sacerdote,Fredrick R. Schumacher,Rodney J. Scott,Rodney J. Scott,Xin Sheng,Xiao-Ou Shu,Amanda B. Spurdle,Deborah J. Thompson,David Van Den Berg,Noel S. Weiss,Lucy Xia,Yong-Bing Xiang,Hannah P. Yang,Herbert Yu,Wei Zheng,Stephen J. Chanock,Peter Kraft +59 more
TL;DR: It is suggested that larger studies with specific tumor classification are necessary to identify novel genetic polymorphisms associated with EC susceptibility, and previously identified associations with genetic markers near the HNF1B locus are replicated.
Posted ContentDOI
Assessment of Polygenic Architecture and Risk Prediction based on Common Variants Across Fourteen Cancers
Yan Zhang,Amber N. Hurson,Haoyu Zhang,Parichoy Pal Choudhury,Douglas F. Easton,Roger L. Milne,Roger L. Milne,Roger L. Milne,Jacques Simard,Per Hall,Kyriaki Michailidou,Kyriaki Michailidou,Joe Dennis,Marjanka K. Schmidt,Jenny Chang-Claude,Jenny Chang-Claude,Puya Gharahkhani,David C. Whiteman,Peter T. Campbell,Michael Hoffmeister,Mark A. Jenkins,Ulrike Peters,Li Hsu,Stephen B. Gruber,Graham Casey,Stephanie L. Schmit,Tracy A. O'Mara,Amanda B. Spurdle,Deborah J. Thompson,Ian Tomlinson,Ian Tomlinson,Immaculata De Vivo,Immaculata De Vivo,Maria Teresa Landi,Matthew Law,Mark M. Iles,Florence Demenais,Rajesh Kumar,Stuart MacGregor,D. Timothy Bishop,Sarah V. Ward,Melissa L. Bondy,Richard S. Houlston,John K. Wiencke,Beatrice Melin,Jill S. Barnholtz-Sloan,Ben Kinnersley,Margaret Wrensch,Christopher I. Amos,Rayjean J. Hung,Paul Brennan,James D. McKay,Neil E. Caporaso,Sonja I. Berndt,Brenda M. Birmann,Nicola J. Camp,Peter Kraft,Nathaniel Rothman,Susan L. Slager,Andrew Berchuck,Paul D.P. Pharoah,Thomas A. Sellers,Simon A. Gayther,Celeste Leigh Pearce,Celeste Leigh Pearce,Ellen L. Goode,Joellen M. Schildkraut,Kirsten B. Moysich,Laufey T. Amundadottir,Eric J. Jacobs,Alison P. Klein,Gloria M. Petersen,Harvey A. Risch,Stolzenberg-Solomon R,Brian M. Wolpin,Donghui Li,Rosalind A. Eeles,Christopher A. Haiman,Zsofia Kote-Jarai,Fredrick R. Schumacher,Ali Amin Al Olama,Mark P. Purdue,Ghislaine Scelo,Marlene Danner Dalgaard,Marlene Danner Dalgaard,Mark H. Greene,Tom Grotmol,Peter A. Kanetsky,Katherine A. McGlynn,Katherine L. Nathanson,Clare Turnbull,Fredrik Wiklund,Bcac,Beacon,Ccfr,Corect,Ecac,GenoMEL,Gicc,Ilcco,InterLymph,Ocac,Oral Cancer Gwas,Panc,PanScan,Practical,Renal Cancer Gwas,Tecac,Stephen J. Chanock,Nilanjan Chatterjee,Montserrat Garcia-Closas +110 more
TL;DR: It is shown that polygenic risk scores have substantial potential for risk stratification for relatively common cancers such as breast, prostate and colon, but limited potential for other cancer sites because of modest heritability and lower disease incidence.
Journal ArticleDOI
Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1
Timothy H.T. Cheng,Deborah J. Thompson,Jodie N. Painter,Tracy A. O'Mara,Maggie Gorman,Lynn Martin,Claire Palles,Angela Jones,Daniel D. Buchanan,Aung Ko Win,John L. Hopper,Mark A. Jenkins,Noralane M. Lindor,Polly A. Newcomb,S. Gallinger,David V. Conti,Fred Schumacher,Graham Casey,Graham G. Giles,Graham G. Giles,Graham G. Giles,Paul D.P. Pharoah,Julian Peto,Angela Cox,Anthony J. Swerdlow,Fergus J. Couch,Julie M. Cunningham,Ellen L. Goode,Stacey J. Winham,Diether Lambrechts,Peter A. Fasching,Peter A. Fasching,Barbara Burwinkel,Barbara Burwinkel,Hermann Brenner,Hermann Brenner,Hiltrud Brauch,Hiltrud Brauch,Jenny Chang-Claude,Helga B. Salvesen,Vessela N. Kristensen,Hatef Darabi,Jingmei Li,Tao Liu,Annika Lindblom,Per Hall,Magdalena Echeverry De Polanco,Mónica Sans,Angel Carracedo,Sergi Castellví-Bel,Augusto Rojas-Martinez,Samuel Aguiar Jnr,Manuel R. Teixeira,Alison M. Dunning,Joe Dennis,Geoffrey Otton,Tony Proietto,Elizabeth G. Holliday,John Attia,Katie Ashton,Rodney J. Scott,Mark McEvoy,Sean C. Dowdy,Brooke L. Fridley,Henrica M.J. Werner,Jone Trovik,Tormund S. Njolstad,Emma Tham,Miriam Mints,Ingo B. Runnebaum,Peter Hillemanns,Thilo Dörk,Frédéric Amant,Stefanie Schrauwen,Alexander Hein,Matthias W. Beckmann,Arif B. Ekici,Kamila Czene,Alfons Meindl,Manjeet K. Bolla,Kyriaki Michailidou,Jonathan Tyrer,Qin Wang,Shahana Ahmed,Catherine S. Healey,Mitul Shah,Daniela Annibali,Jeroen Depreeuw,Nada Al-Tassan,Rebecca Harris,Brian F. Meyer,Nicola Whiffin,Fay J. Hosking,Ben Kinnersley,Susan M. Farrington,Maria Timofeeva,Albert Tenesa,Harry Campbell,Robert W. Haile,Shirley Hodgson,Luis G. Carvajal-Carmona,Jeremy Peter Cheadle,Douglas F. Easton,Malcolm G. Dunlop,Richard S. Houlston,Amanda B. Spurdle,Ian Tomlinson +106 more
TL;DR: Using CRC and EC genome-wide association series, it was found that the protective allele at one previously-identified CRC polymorphism was associated with EC risk, and neither of two previously-reported EC polymorphisms were associated with CRC risk.
Journal ArticleDOI
Risk Prediction Models for Colorectal Cancer Incorporating Common Genetic Variants: A Systematic Review
Luke McGeoch,Catherine L. Saunders,Simon J. Griffin,Jon Emery,Fiona M Walter,Deborah J. Thompson,Antonis C. Antoniou,Juliet A. Usher-Smith +7 more
TL;DR: This review updated the previous review by searching Medline and EMBASE to identify models incorporating at least one SNP and applicable to asymptomatic individuals in the general population and identified 23 new models, giving a total of 29.
Journal ArticleDOI
Two ATM variants and breast cancer risk.
Deborah J. Thompson,Deborah J. Thompson,Antonis C. Antoniou,Mark A. Jenkins,Anna Marsh,Xiaoqing Chen,Tierney L. Wayne,Andrea Tesoriero,Roger L. Milne,Amanda B. Spurdle,Yvonne R. Thorstenson,Melissa C. Southey,Graham G. Giles,kConFab Investigators,Kum Kum Khanna,Joseph Sambrook,Peter J. Oefner,David E. Goldgar,John L. Hopper,Doug Easton,Georgia Chenevix-Trench +20 more
TL;DR: Examining two ATM variants in additional cases and controls from the same Australian cohorts previously used to estimate the risk of breast cancer associated with c.1066‐6T>G found no evidence that the ATM c.4258C>T variant increases breast cancer risk, and little evidence that it confers an elevated risk.