E
Edward F. Srour
Researcher at Indiana University
Publications - 204
Citations - 10614
Edward F. Srour is an academic researcher from Indiana University. The author has contributed to research in topics: Stem cell & Haematopoiesis. The author has an hindex of 51, co-authored 202 publications receiving 9991 citations. Previous affiliations of Edward F. Srour include Indiana University – Purdue University Indianapolis & University of New Mexico.
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Journal ArticleDOI
Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist
Hal E. Broxmeyer,Christie M. Orschell,D. Wade Clapp,Giao Hangoc,Scott Cooper,P. Artur Plett,W. Conrad Liles,Xiaxin Li,Barbara Graham-Evans,Timothy B. Campbell,Gary Calandra,Gary Bridger,David C. Dale,Edward F. Srour +13 more
TL;DR: Results support the hypothesis that the CXCL12-CXCR4 axis is involved in marrow retention of HSCs and HPCs, and demonstrate the clinical potential of AMD3100 for HSC mobilization.
Journal ArticleDOI
Estradiol-regulated microRNAs control estradiol response in breast cancer cells
Poornima Bhat-Nakshatri,Guohua Wang,Nikail Collins,Michael J. Thomson,Tim R. Geistlinger,Jason S. Carroll,Myles Brown,Scott M. Hammond,Edward F. Srour,Yunlong Liu,Harikrishna Nakshatri +10 more
TL;DR: It is proposed that the clinical course of ERα-positive breast cancers is dependent on the balance between E2-regulated tumor-suppressor micro RNAs and oncogenic microRNAs, and a negative-regulatory loop controlling E2 response through microRN as well as differences in E1-induced transcriptome and proteome.
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Cell Cycle-Related Changes in Repopulating Capacity of Human Mobilized Peripheral Blood CD34+ Cells in Non-Obese Diabetic/Severe Combined Immune-Deficient Mice
TL;DR: The use of cell cycle fractionation to separate human mobilized peripheral blood CD34(+) cells capable of repopulating the bone marrow (BM) of non-obese diabetic/severe combined immune-deficient (NOD/SCID) mice is reported here and demonstrates that G0-G1 progression in vitro is associated with a decrease in engraftment capacity.
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Efficient retrovirus-mediated transfer of the multidrug resistance 1 gene into autologous human long-term repopulating hematopoietic stem cells.
Rafat Abonour,David R. Williams,Lawrence H. Einhorn,Kristin M. Hall,Jun Chen,John Coffman,C. M. Traycoff,Arthur Bank,Ikunoshin Kato,Maureen Ward,Stephen D. Williams,Robert Hromas,Michael J. Robertson,Franklin O. Smith,David Woo,Bonnie Mills,Edward F. Srour,Kenneth Cornetta +17 more
TL;DR: Pre-clinical studies indicate that efficient retrovirus-mediated gene transfer into hematopoietic stem cells and progenitor cells can be achieved by co-localizing retroviral particles and target cells on specific adhesion domains of fibronectin.
Journal ArticleDOI
Enhancing Hematopoietic Stem Cell Transplantation Efficacy by Mitigating Oxygen Shock.
Charlie Mantel,Heather O'Leary,Brahmananda R. Chitteti,Xinxin Huang,Scott Cooper,Giao Hangoc,Nickolay Brustovetsky,Edward F. Srour,Man Ryul Lee,Man Ryul Lee,Steve Messina-Graham,David M. Haas,Nadia Falah,Reuben Kapur,Louis M. Pelus,Nabeel Bardeesy,Julien Fitamant,Mircea Ivan,Kye Seong Kim,Hal E. Broxmeyer +19 more
TL;DR: In this article, the extraphysiologic oxygen shock/stress (EPHOSS) phenomenon was found to decrease the recovery of long-term repopulating HSCs and increase progenitor cells.