G
George Thomas
Researcher at Health Science University
Publications - 14
Citations - 1550
George Thomas is an academic researcher from Health Science University. The author has contributed to research in topics: Ribosome biogenesis & Translation (biology). The author has an hindex of 10, co-authored 14 publications receiving 1252 citations. Previous affiliations of George Thomas include University of Dundee & University of Cincinnati Academic Health Center.
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Journal ArticleDOI
A guide to analysis of mouse energy metabolism
Matthias H. Tschöp,John R. Speakman,John R. Speakman,Jonathan R.S. Arch,Johan Auwerx,Jens C. Brüning,Lawrence Chan,Robert H. Eckel,Robert V. Farese,Jose E. Galgani,Catherine Hambly,Mark A. Herman,Tamas L. Horvath,Barbara B. Kahn,Sara C. Kozma,Eleftheria Maratos-Flier,Timo D. Müller,Heike Münzberg,Paul T. Pfluger,Leona Plum,Marc L. Reitman,Kamal Rahmouni,Gerald I. Shulman,George Thomas,C. Ronald Kahn,Eric Ravussin +25 more
TL;DR: A consolidated view of the complexity and challenges of designing studies for measurement of energy metabolism in mouse models is presented, including a practical guide to the assessment of energy expenditure, energy intake and body composition and statistical analysis thereof.
Journal ArticleDOI
A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis
Andrea Alimonti,Caterina Nardella,Zhenbang Chen,John G. Clohessy,Arkaitz Carracedo,Lloyd C. Trotman,Ke Cheng,Shohreh Varmeh,Sara C. Kozma,George Thomas,Erika Rosivatz,Rudiger Woscholski,Francesco Cognetti,Howard I. Scher,Pier Paolo Pandolfi +14 more
TL;DR: The data identify a type of cellular senescence that can be triggered in nonproliferating cells in the absence of DNA damage, which is useful for developing a "pro-senescence" approach for cancer prevention and therapy.
Journal ArticleDOI
mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer
Amaia Zabala-Letona,Amaia Arruabarrena-Aristorena,Natalia Martín-Martín,Sonia Fernández-Ruiz,James D. Sutherland,Michelle Clasquin,Julen Tomás-Cortázar,Jose Jimenez,Inés Cristina Torres,Phong Quang,Pilar Ximénez-Embún,Ruzica Bago,Aitziber Ugalde-Olano,Ana Loizaga-Iriarte,Isabel Lacasa-Viscasillas,Miguel Unda,Verónica Torrano,Diana Cabrera,Sebastiaan M. Van Liempd,Ylenia Cendon,Elena Castro,Stuart Murray,Ajinkya Revandkar,Andrea Alimonti,Yinan Zhang,Amelia Barnett,Gina Lein,David Pirman,Ana R. Cortazar,Leire Arreal,Ludmila Prudkin,Ianire Astobiza,Lorea Valcarcel-Jimenez,Patricia Zúñiga-García,Itziar Fernández-Domínguez,Marco Piva,Alfredo Caro-Maldonado,Pilar Sanchez-Mosquera,Mireia Castillo-Martin,Mireia Castillo-Martin,Violeta Serra,Violeta Serra,Naiara Beraza,Antonio Gentilella,George Thomas,Mikel Azkargorta,Felix Elortza,Rosa Farràs,David Olmos,Alejo Efeyan,Juan Anguita,Javier Muñoz,Juan M. Falcón-Pérez,Juan M. Falcón-Pérez,Rosa Barrio,Teresa Macarulla,Teresa Macarulla,José M. Mato,María L. Martínez-Chantar,Carlos Cordon-Cardo,Ana M. Aransay,Kevin R Marks,José Baselga,Josep Tabernero,Josep Tabernero,Paolo Nuciforo,Brendan D. Manning,Katya Marjon,Arkaitz Carracedo +68 more
TL;DR: It is shown that mechanistic target of rapamycin complex 1 (mTORC1) regulates polyamine dynamics, a metabolic route that is essential for oncogenicity.
Journal ArticleDOI
A liaison between mTOR signaling, ribosome biogenesis and cancer
TL;DR: The most recent findings concerning the underlying mechanisms by which mTOR signaling controls ribosomes production and the potential impact of ribosome biogenesis in tumor development are discussed.
Journal ArticleDOI
Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program
Maxime Janin,Vanessa Ortiz-Barahona,Manuel Castro de Moura,Anna Martínez-Cardús,Pere Llinàs-Arias,Marta Soler,Daphna Nachmani,Joffrey Pelletier,Ulrike Schumann,Maria E. Calleja-Cervantes,Sebastian Moran,Sonia Guil,Alberto Bueno-Costa,David Piñeyro,Montserrat Pérez-Salvia,Margalida Rosselló-Tortella,Laia Piqué,Joan Josep Bech-Serra,Carolina De La Torre,August Vidal,María Martínez-Iniesta,Juan F. Martín-Tejera,Alberto Villanueva,Alexandra Arias,Isabel Cuartas,Ana M. Aransay,Andres Morales La Madrid,Angel M. Carcaboso,Vicente Santa-Maria,Jaume Mora,Agustín F. Fernández,Mario F. Fraga,Iban Aldecoa,Leire Pedrosa,Francesc Graus,Noemi Vidal,Fina Martínez-Soler,Avelina Tortosa,Cristina Carrato,C. Balana,Matthew W. Boudreau,Paul J. Hergenrother,Peter Kötter,K. D. Entian,Jürgen Hench,Stephan Frank,Sheila Mansouri,Gelareh Zadeh,Pablo D. Dans,Modesto Orozco,George Thomas,George Thomas,Sandra Blanco,Joan Seoane,Joan Seoane,Thomas Preiss,Thomas Preiss,Pier Paolo Pandolfi,Manel Esteller +58 more
TL;DR: It is found that human glioma cells undergo DNA methylation-associated epigenetic silencing of NSUN5, a candidate RNA methyltransferase for 5-methylcytosine, which exhibits tumor-suppressor characteristics in vivo gliomas models and leads to the emergence of an adaptive translational program for survival under conditions of cellular stress.