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Ira Pastan
Researcher at Laboratory of Molecular Biology
Publications - 1304
Citations - 113191
Ira Pastan is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Immunotoxin & Pseudomonas exotoxin. The author has an hindex of 160, co-authored 1286 publications receiving 110069 citations. Previous affiliations of Ira Pastan include Heidelberg University & National Institutes of Health.
Papers
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Journal ArticleDOI
Biochemistry of multidrug resistance mediated by the multidrug transporter.
Michael M. Gottesman,Ira Pastan +1 more
Journal ArticleDOI
Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues
Franz Thiebaut,Takashi Tsuruo,Hirofumi Hamada,Michael M. Gottesman,Ira Pastan,Mark C. Willingham +5 more
TL;DR: The results suggest that the protein has a role in the normal secretion of metabolites and certain anti-cancer drugs into bile, urine, and directly into the lumen of the gastrointestinal tract.
Journal ArticleDOI
Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells
Chang jie Chen,Janice E. Chin,Kazumitsu Ueda,Douglas P. Clark,Ira Pastan,Michael M. Gottesman,Igor B. Roninson +6 more
TL;DR: Results are consistent with a function for P-glycoprotein as an energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Journal ArticleDOI
Expression of a multidrug-resistance gene in human tumors and tissues
TL;DR: The results suggest that measurement of mdr1 RNA may prove to be a valuable tool in the design of chemotherapy protocols and controlled clinical studies will be required.
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Expression of Multidrug Resistance Gene in Human Cancers
Lori J. Goldstein,Hanan Galski,Antonio Tito Fojo,Mark C. Willingham,Shinn Lian Lai,Adi F. Gazdar,Robert Pirker,Alexander A. Green,William M. Crist,Garrett M. Brodeur,Michael M. Lieber,Jeffrey Cossman,Michael M. Gottesman,Ira Pastan +13 more
TL;DR: Evaluation of MDR1 gene expression may prove to be a valuable tool in the identification of individuals whose cancers are resistant to specific agents, and the information may be useful in designing or altering chemotherapeutic protocols in these patients.